Research Output

2020

A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor

Rimbert, A., Dalila, N., Wolters, J. C., Huijkman, N., Smit, M., Kloosterhuis, N., Riemsma, M., Van Der Veen, Y., Singla, A., Van Dijk, F., Frikke-Schmidt, R., Burstein, E., Tybjærg-Hansen, A., Van De Sluis, B. & Kuivenhoven, J. A., Mar 1 2020, In : European heart journal. 41, 9, p. 1040-1053 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Amino Acid Sensing: Architecture of mTORC1 on the Lysosome Surface

Peng, W. & Jewell, J. L., Jan 20 2020, In : Current Biology. 30, 2, p. R89-R91

Research output: Contribution to journalArticle

1 Scopus citations

Antisense-Mediated Transcript Knockdown Triggers Premature Transcription Termination

Lee, J. S. & Mendell, J. T., Mar 5 2020, In : Molecular cell. 77, 5, p. 1044-1054.e3

Research output: Contribution to journalArticle

2 Scopus citations

Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex

D'Souza, R. S., Lim, J. Y., Turgut, A., Servage, K., Zhang, J., Orth, K., Sosale, N. G., Lazzara, M. J., Allegood, J. & Casanova, J. E., Apr 1 2020, In : eLife. 9

Research output: Contribution to journalArticle

Open Access

CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleus

Cho, Y. S., Li, S., Wang, X., Zhu, J., Zhuo, S., Han, Y., Yue, T., Yang, Y. & Jiang, J., Jan 1 2020, In : Genes & development. 34, 1-2, p. 53-71 19 p.

Research output: Contribution to journalArticle

Open Access

CK1α, CK1δ, and CK1ε are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis

Hanna-Addams, S., Liu, S., Liu, H., Chen, S. & Wang, Z., Jan 28 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 4, p. 1962-1970 9 p.

Research output: Contribution to journalArticle

CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart

Schoger, E., Carroll, K. J., Iyer, L. M., McAnally, J. R., Tan, W., Liu, N., Noack, C., Shomroni, O., Salinas, G., Groß, J., Herzog, N., Doroudgar, S., Bassel-Duby, R., Zimmermann, W. H. & Zelarayán, L. C., Jan 1 2020, (Accepted/In press) In : Circulation research. p. 6-24 19 p.

Research output: Contribution to journalArticle

Open Access

Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing

Cui, M., Wang, Z., Chen, K., Shah, A. M., Tan, W., Duan, L., Sanchez-Ortiz, E., Li, H., Xu, L., Liu, N., Bassel-Duby, R. & Olson, E. N., Apr 6 2020, In : Developmental cell. 53, 1, p. 102-116.e8

Research output: Contribution to journalArticle

Enhanced CRISPR-Cas9 correction of Duchenne muscular dystrophy in mice by a self-complementary AAV delivery system

Zhang, Y., Li, H., Min, Y. L., Sanchez-Ortiz, E., Huang, J., Mireault, A. A., Shelton, J. M., Kim, J., Mammen, P. P. A., Bassel-Duby, R. & Olson, E. N., Jan 1 2020, In : Science Advances. 6, 8, eaay6812.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

GCNA Preserves Genome Integrity and Fertility Across Species

Bhargava, V., Goldstein, C. D., Russell, L., Xu, L., Ahmed, M., Li, W., Casey, A., Servage, K., Kollipara, R., Picciarelli, Z., Kittler, R., Yatsenko, A., Carmell, M., Orth, K., Amatruda, J. F., Yanowitz, J. L. & Buszczak, M., Jan 6 2020, In : Developmental cell. 52, 1, p. 38-52.e10

Research output: Contribution to journalArticle

3 Scopus citations

Glutamine and asparagine activate mTORC1 independently of Rag GTPases

Meng, D., Yang, Q., Wang, H., Melick, C. H., Navlani, R., Frank, A. R. & Jewell, J. L., Mar 6 2020, In : Journal of Biological Chemistry. 295, 10, p. 2890-2899 10 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy

Hernandez, G., Luo, T., Javed, T. A., Wen, L., Kalwat, M. A., Vale, K., Ammouri, F., Husain, S. Z., Kliewer, S. A. & Mangelsdorf, D. J., Jan 8 2020, In : Science Translational Medicine. 12, 525, eaay5186.

Research output: Contribution to journalArticle

2 Scopus citations

Structural and mechanistic insights into secretagogin-mediated exocytosis

Qin, J., Liu, Q., Liu, Z., Pan, Y. Z., Sifuentes-Dominguez, L., Stepien, K. P., Wang, Y., Tu, Y., Tan, S., Wang, Y., Sun, Q., Mo, X., Rizo, J., Burstein, E. & Jia, D., Mar 24 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 12, p. 6559-6570 12 p.

Research output: Contribution to journalArticle

Toward the Goal of Human Heart Regeneration

Sadek, H. & Olson, E. N., Jan 2 2020, In : Cell Stem Cell. 26, 1, p. 7-16 10 p.

Research output: Contribution to journalReview article

2019

Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

Hu, Z., Qu, G., Yu, X., Jiang, H., Teng, X. L., Ding, L., Hu, Q., Guo, X., Zhou, Y., Wang, F., Li, H. B., Chen, L., Jiang, J., Su, B., Liu, J. & Zou, Q., Aug 6 2019, In : Cell Metabolism. 30, 2, p. 290-302.e5

Research output: Contribution to journalArticle

5 Scopus citations

Adhesins during infection

Krachler, A. M. & Orth, K., Jan 1 2019, Encyclopedia of Microbiology. Elsevier, p. 28-37 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

Kliewer, S. A. & Mangelsdorf, D. J., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 246-253 8 p.

Research output: Contribution to journalReview article

21 Scopus citations

Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction

Egge, N., Arneaud, S. L. B., Wales, P., Mihelakis, M., McClendon, J., Fonseca, R. S., Savelle, C., Gonzalez, I., Ghorashi, A., Yadavalli, S., Lehman, W. J., Mirzaei, H. & Douglas, P. M., Dec 2 2019, In : Developmental cell. 51, 5, p. 587-601.e7

Research output: Contribution to journalArticle

A novel mouse model of enteric vibrio parahaemolyticus infection reveals that the type iii secretion system 2 effector vopc plays a key role in tissue invasion and gastroenteritis

Yang, H., Santos, M. D. S., Lee, J., Law, H. T., Chimalapati, S., Verdu, E. F., Vallance, B. A. & Orth, K., Nov 1 2019, In : mBio. 10, 6, e02608-19.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Astrocyte-Specific Deletion of Sox2 Promotes Functional Recovery After Traumatic Brain Injury

Chen, C., Zhong, X., Smith, D. K., Tai, W., Yang, J., Zou, Y., Wang, L. L., Sun, J., Qin, S. & Zhang, C-L., Jan 1 2019, In : Cerebral cortex (New York, N.Y. : 1991). 29, 1, p. 54-69 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Author Correction: miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2 (Nature, (2014), 512, 7515, (431-435), 10.1038/nature13375)

Krzeszinski, J. Y., Wei, W., Huynh, H. D., Jin, Z., Wang, X., Chang, T-C., Xie, X-J., He, L., Mangala, L. S., Lopez-Berestein, G., Sood, A. K., Mendell, J. T. & Wan, Y., Jan 1 2019, In : Nature.

Research output: Contribution to journalComment/debate

Open Access

Autophagy Keeps the Balance in Tissue Homeostasis

Buszczak, M. & Krämer, H., May 20 2019, In : Developmental cell. 49, 4, p. 499-500 2 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers

Hashimoto, H., Wang, Z., Garry, G. A., Malladi, V. S., Botten, G. A., Ye, W., Zhou, H., Osterwalder, M., Dickel, D. E., Visel, A., Liu, N., Bassel-Duby, R. & Olson, E. N., Jul 3 2019, In : Cell Stem Cell. 25, 1, p. 69-86.e5

Research output: Contribution to journalArticle

4 Scopus citations

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution

Hosein, A. N., Huang, H., Wang, Z., Parmar, K., Du, W., Huang, J., Maitra, A., Olson, E. N., Verma, U. & Brekken, R. A., Jul 23 2019, In : JCI Insight. 4, 16, e129212.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model

Xiao, N., Wei, J., Xu, S., Du, H., Huang, M., Zhang, S., Ye, W., Sun, L. & Chen, Q., Jun 2019, In : Journal of Autoimmunity. 100, p. 84-94 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Charactering hescs organoids from electrical signals with machine learning

Hasib, M., Lybrand, Z., Estevez, V. N., Hsieh, J. & Huang, Y., May 2019, 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 8834587. (2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Clearing debris

Meng, D. & Jewell, J. L., Aug 1 2019, In : Nature chemical biology. 15, 8, p. 760-761 2 p.

Research output: Contribution to journalComment/debate

CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells

Min, Y. L., Li, H., Rodriguez-Caycedo, C., Mireault, A. A., Huang, J., Shelton, J. M., McAnally, J. R., Amoasii, L., Mammen, P. P. A., Bassel-Duby, R. & Olson, E. N., Jan 1 2019, In : Science Advances. 5, 3, eaav4324.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Defective DNA Polymerase α-Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism

Van Esch, H., Colnaghi, R., Freson, K., Starokadomskyy, P., Zankl, A., Backx, L., Abramowicz, I., Outwin, E., Rohena, L., Faulkner, C., Leong, G. M., Newbury-Ecob, R. A., Challis, R. C., Õunap, K., Jaeken, J., Seuntjens, E., Devriendt, K., Burstein, E., Low, K. J. & O'Driscoll, M., May 2 2019, In : American Journal of Human Genetics. 104, 5, p. 957-967 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection

De Nisco, N. J., Neugent, M., Mull, J. A., Chen, L., Kuprasertkul, A., de Souza Santos, M., Palmer, K. L., Zimmern, P. E. & Orth, K. A., Jan 1 2019, In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

5 Scopus citations

Dissecting primate early post-implantation development using long-term in vitro embryo culture

Niu, Y., Sun, N., Li, C., Lei, Y., Huang, Z., Wu, J., Si, C., Dai, X., Liu, C., Wei, J., Liu, L., Feng, S., Kang, Y., Si, W., Wang, H., Zhang, E., Zhao, L., Li, Z., Luo, X., Cui, G. & 4 others, Peng, G., Belmonte, J. C. I., Ji, W. & Tan, T., Nov 15 2019, In : Science. 366, 6467, eaaw5754.

Research output: Contribution to journalArticle

7 Scopus citations

Drosophila Myoblast Fusion: Invasion and Resistance for the Ultimate Union

Lee, D. M. & Chen, E. H., Jan 1 2019, In : Annual review of genetics. 53, p. 67-91 25 p.

Research output: Contribution to journalReview article

1 Scopus citations

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

Zhu, W., Miyata, N., Winter, M. G., Arenales, A., Hughes, E. R., Spiga, L., Kim, J., Sifuentes-Dominguez, L., Starokadomskyy, P., Gopal, P., Byndloss, M. X., Santos, R. L., Burstein, E. & Winter, S. E., Jan 1 2019, In : Journal of Experimental Medicine. 216, 10, p. 2378-2393 16 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Embryonic chimeras with human pluripotent stem cells

De Los Angeles, A., Sakurai, M. & Wu, J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 125-151 27 p. (Methods in Molecular Biology; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Singla, A., Fedoseienko, A., Giridharan, S. S. P., Overlee, B. L., Lopez, A., Jia, D., Song, J., Huff-Hardy, K., Weisman, L., Burstein, E. & Billadeau, D. D., Dec 1 2019, In : Nature communications. 10, 1, 4271.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access

Ex Vivo Transposon-Mediated Genetic Screens for Cancer Gene Discovery

O'Donnell-Mendell, K. A., Guo, Y., Suresh, S., Updegraff, B. L. & Zhou, X., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 145-157 13 p. (Methods in Molecular Biology; vol. 1907).

Research output: Chapter in Book/Report/Conference proceedingChapter

Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures

Li, R., Zhong, C., Yu, Y., Liu, H., Sakurai, M., Yu, L., Min, Z., Shi, L., Wei, Y., Takahashi, Y., Liao, H. K., Qiao, J., Deng, H., Nuñez-Delicado, E., Rodriguez Esteban, C., Wu, J. & Izpisua Belmonte, J. C., Oct 17 2019, In : Cell. 179, 3, p. 687-702.e18

Research output: Contribution to journalArticle

10 Scopus citations

Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system

Xu, J., Yu, L., Guo, J., Xiang, J., Zheng, Z., Gao, D., Shi, B., Hao, H., Jiao, D., Zhong, L., Wang, Y., Wu, J., Wei, H. & Han, J., Jun 27 2019, In : Stem Cell Research and Therapy. 10, 1, 193.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

Jewell, J. L., Fu, V., Hong, A. W., Yu, F. X., Meng, D., Melick, C. H., Wang, H., Lam, W. L. M., Yuan, H. X., Taylor, S. S. & Guan, K. L., May 21 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Highly efficient derivation of pluripotent stem cells from mouse preimplantation and postimplantation embryos in serum-free conditions

De Los Angeles, A., Okamura, D. & Wu, J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 29-36 8 p. (Methods in Molecular Biology; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingChapter

High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice

Peri-Okonny, P., Baskin, K. K., Iwamoto, G., Mitchell, J. H., Smith, S. A., Kim, H. K., Szweda, L. I., Bassel-Duby, R., Fujikawa, T., Castorena, C. M., Richardson, J., Shelton, J. M., Ayers, C., Berry, J. D., Malladi, V. S., Hu, M. C., Moe, O. W., Scherer, P. E. & Vongpatanasin, W., Mar 12 2019, In : Circulation. 139, 11, p. 1422-1434 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

High-resolution cryo-EM structures of the E. Coli hemolysin ClyA oligomers

Peng, W., de Souza Santos, M., Li, Y., Tomchick, D. R. & Orth, K., May 2019, In : PloS one. 14, 5, e0213423.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Hippo signaling is intrinsically regulated during cell cycle progression by APC/C Cdh1

Kim, W., Cho, Y. S., Wang, X., Park, O., Ma, X., Kim, H., Gan, W., Jho, E. H., Cha, B., Jeung, Y. J., Zhang, L., Gao, B., Wei, W., Jiang, J., Chung, K. S. & Yang, Y., May 7 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 19, p. 9423-9432 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

Stefanius, K., Servage, K., de Souza Santos, M., Gray, H. F., Toombs, J. E., Chimalapati, S., Kim, M. S., Malladi, V. S., Brekken, R. & Orth, K., May 28 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

In vitro breeding: Application of embryonic stem cells to animal production

Goszczynski, D. E., Cheng, H., Demyda-Peyrás, S., Medrano, J. F., Wu, J. & Ross, P. J., Jan 1 2019, In : Biology of reproduction. 100, 4, p. 885-895 11 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation

Braitsch, C. M., Azizoglu, D. B., Htike, Y., Barlow, H. R., Schnell, U., Chaney, C. P., Carroll, T. J., Stanger, B. Z. & Cleaver, O., Jul 1 2019, In : PLoS biology. 17, 7, e3000382.

Research output: Contribution to journalArticle

Open Access

Livestock pluripotency is finally captured in vitro

Navarro, M., Soto, D. A., Pinzon, C. A., Wu, J. & Ross, P. J., Dec 2 2019, In : Reproduction, Fertility and Development. 32, 2, p. 11-39 29 p.

Research output: Contribution to journalArticle

Macrophage Smad3 protects the infarcted heart, stimulating phagocytosis and regulating inflammation

Chen, B., Huang, S., Su, Y., Wu, Y. J., Hanna, A., Brickshawana, A., Graff, J. & Frangogiannis, N. G., Jan 1 2019, In : Circulation research. 125, 1, p. 55-70 16 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling

Wang, Z., Cui, M., Shah, A. M., Ye, W., Tan, W., Min, Y. L., Botten, G. A., Shelton, J. M., Liu, N., Bassel-Duby, R. S. & Olson, E. N., Sep 10 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18455-18465 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations