Pharmacology - Chook Lab

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2019

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

Padavannil, A., Sarkar, P., Kim, S. J., Cagatay, T., Jiou, J., Brautigam, C. A., Tomchick, D. R., Sali, A., D’Arcy, S. & Chook, Y. M., Mar 2019, In : eLife. 8, e43630.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access
3 Scopus citations
2018

Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization

Pinarbasi, E. S., Caǧatay, T., Fung, H. Y. J., Li, Y. C., Chook, Y. M. & Thomas, P. J., Dec 1 2018, In : Scientific Reports. 8, 1, 7083.

Research output: Contribution to journalArticle

19 Scopus citations

Correlation of CRM1-NES affinity with nuclear export activity

Fu, S. C., Fung, H. Y. J., Caǧatay, T., Baumhardt, J. & Chook, Y. M., Aug 15 2018, In : Molecular Biology of the Cell. 29, 17, p. 2037-2044 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Günter Blobel 1936–2018

Chook, Y. M., Fontoura, B. M. A. & Rout, M. P., Apr 2 2018, (Accepted/In press) In : Nature Structural and Molecular Biology. p. 1-2 2 p.

Research output: Contribution to journalArticle

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

Yoshizawa, T., Ali, R., Jiou, J., Fung, H. Y. J., Burke, K. A., Kim, S. J., Lin, Y., Peeples, W. B., Saltzberg, D., Soniat, M., Baumhardt, J. M., Oldenbourg, R., Sali, A., Fawzi, N. L., Rosen, M. K. & Chook, Y. M., Jan 1 2018, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

55 Scopus citations

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

Guo, L., Kim, H. J., Wang, H., Monaghan, J., Freyermuth, F., Sung, J. C., O'Donovan, K., Fare, C. M., Diaz, Z., Singh, N., Zhang, Z. C., Coughlin, M., Sweeny, E. A., DeSantis, M. E., Jackrel, M. E., Rodell, C. B., Burdick, J. A., King, O. D., Gitler, A. D., Lagier-Tourenne, C. & 4 others, Pandey, U. B., Chook, Y. M., Taylor, J. P. & Shorter, J., Apr 19 2018, In : Cell. 173, 3, p. 677-692.e20

Research output: Contribution to journalArticle

80 Scopus citations

Structural–functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression

Zhang, K., Shang, G., Padavannil, A., Wang, J., Sakthivel, R., Chen, X., Kim, M., Thompson, M. G., García-Sastre, A., Lynch, K. W., Chen, Z., Chook, Y. M. & Fontoura, B. M., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. E12218-E12227

Research output: Contribution to journalArticle

1 Scopus citations
2017

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

Fung, H. Y. J., Fu, S. C. & Chook, Y. M., Mar 10 2017, In : eLife. 6, e23961.

Research output: Contribution to journalArticle

19 Scopus citations
2016

Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E

Volpon, L., Culjkovic-Kraljacic, B., Osborne, M. J., Ramteke, A., Sun, Q., Niesman, A., Chook, Y. M. & Borden, K. L. B., May 10 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 19, p. 5263-5268 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Karyopherin-β2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif

Soniat, M. & Chook, Y. M., Oct 4 2016, In : Structure. 24, 10, p. 1802-1809 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies

Hing, Z. A., Fung, H. Y. J., Ranganathan, P., Mitchell, S., El-Gamal, D., Woyach, J. A., Williams, K., Goettl, V. M., Smith, J., Yu, X., Meng, X., Sun, Q., Cagatay, T., Lehman, A. M., Lucas, D. M., Baloglu, E., Shacham, S., Kauffman, M. G., Byrd, J. C., Chook, Y. M. & 2 others, Garzon, R. & Lapalombella, R., Jun 21 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

40 Scopus citations

Recognition elements in the histone H3 and H4 tails for seven different importins

Soniat, M., Caǧatay, T. & Chook, Y. M., Sep 30 2016, In : Journal of Biological Chemistry. 291, 40, p. 21171-21183 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

Haines, J. D., Herbin, O., De La Hera, B., Vidaurre, O. G., Moy, G. A., Sun, Q., Fung, H. Y. J., Albrecht, S., Alexandropoulos, K., McCauley, D., Chook, Y. M., Kuhlmann, T., Kidd, G. J., Shacham, S. & Casaccia, P., Apr 28 2015, In : Nature neuroscience. 18, 4, p. 511-520 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Nuclear localization signals for four distinct Karyopherin-β nuclear import systems

Soniat, M. & Chook, Y. M., Jun 15 2015, In : Biochemical Journal. 468, 3, p. 353-362 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Structural determinants of nuclear export signal orientation in binding to exportin CRM1

Fung, H. Y. J., Fu, S. C., Brautigam, C. A. & Chook, Y. M., Sep 8 2015, In : eLife. 4, September 2015, e10034.

Research output: Contribution to journalArticle

30 Scopus citations
2014

LocNES: A computational tool for locating classical NESs in CRM1 cargo proteins

Xu, D., Marquis, K., Pei, J., Fu, S. C., Caʇatay, T., Grishin, N. V. & Chook, Y. M., Nov 5 2014, In : Bioinformatics. 31, 9, p. 1357-1365 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration

Bernis, C., Swift-Taylor, B., Nord, M., Carmona, S., Chook, Y. M. & Forbes, D. J., Apr 1 2014, In : Molecular biology of the cell. 25, 7, p. 992-1009 18 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

Etchin, J., Sun, Q., Kentsis, A., Farmer, A., Zhang, Z. C., Sanda, T., Mansour, M. R., Barcelo, C., McCauley, D., Kauffman, M., Shacham, S., Christie, A. L., Kung, A. L., Rodig, S. J., Chook, Y. M. & Look, A. T., Jan 1 2013, In : Leukemia. 27, 1, p. 66-74 9 p.

Research output: Contribution to journalArticle

105 Scopus citations

Crystal structure of human Karyopherin β2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2

Soniat, M., Sampathkumar, P., Collett, G., Gizzi, A. S., Banu, R. N., Bhosle, R. C., Chamala, S., Chowdhury, S., Fiser, A., Glenn, A. S., Hammonds, J., Hillerich, B., Khafizov, K., Love, J. D., Matikainen, B., Seidel, R. D., Toro, R., Rajesh Kumar, P., Bonanno, J. B., Chook, Y. M. & 1 others, Almo, S. C., Jun 1 2013, In : Journal of Structural and Functional Genomics. 14, 2, p. 31-35 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

Sun, Q., Carrasco, Y. P., Hu, Y., Guo, X., Mirzaei, H., MacMillan, J. & Chook, Y. M., Jan 22 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. 1303-1308 6 p.

Research output: Contribution to journalArticle

84 Scopus citations
2012

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

Lapalombella, R., Sun, Q., Williams, K., Tangeman, L., Jha, S., Zhong, Y., Goettl, V., Mahoney, E., Berglund, C., Gupta, S., Farmer, A., Mani, R., Johnson, A. J., Lucas, D., Mo, X., Daelemans, D., Sandanayaka, V., Shechter, S., McCauley, D., Shacham, S. & 3 others, Kauffman, M., Chook, Y. M. & Byrd, J. C., Nov 29 2012, In : Blood. 120, 23, p. 4621-4634 14 p.

Research output: Contribution to journalArticle

168 Scopus citations

Sequence and structural analyses of nuclear export signals in the NESdb database

Xu, D., Farmer, A., Collett, G., Grishin, N. V. & Chook, Y. M., Sep 15 2012, In : Molecular biology of the cell. 23, 18, p. 3677-3693 17 p.

Research output: Contribution to journalArticle

64 Scopus citations
68 Scopus citations
2011

Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1

Zhang, Z. C., Satterly, N., Fontoura, B. M. A. & Chook, Y. M., Dec 1 2011, In : Molecular biology of the cell. 22, 23, p. 4657-4668 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Importin-α protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP)

Ge, Q., Nakagawa, T., Max Wynn, R., Chook, Y. M., Miller, B. C. & Uyeda, K., Aug 12 2011, In : Journal of Biological Chemistry. 286, 32, p. 28119-28127 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2009

Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus

Süel, K. E. & Chook, Y. M., Jun 5 2009, In : Journal of Biological Chemistry. 284, 23, p. 15416-15424 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Structural basis for assembly and disassembly of the CRM1 nuclear export complex

Dong, X., Biswas, A. & Chook, Y. M., May 1 2009, In : Nature Structural and Molecular Biology. 16, 5, p. 558-560 3 p.

Research output: Contribution to journalArticle

64 Scopus citations

Structural basis for leucine-rich nuclear export signal recognition by CRM1

Dong, X., Biswas, A., Süel, K. E., Jackson, L. K., Martinez, R., Gu, H. & Chook, Y. M., Apr 30 2009, In : Nature. 458, 7242, p. 1136-1141 6 p.

Research output: Contribution to journalArticle

202 Scopus citations
2008

Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signals

Süel, K. E., Gu, H. & Chook, Y. M., Jun 1 2008, In : PLoS biology. 6, 6, p. 1253-1267 15 p., e137.

Research output: Contribution to journalArticle

55 Scopus citations
2007

Conformational Heterogeneity of Karyopherinβ2 Is Segmental

Cansizoglu, A. E. & Chook, Y. M., Nov 13 2007, In : Structure. 15, 11, p. 1431-1441 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Structure-based design of a pathway-specific nuclear import inhibitor

Cansizoglu, A. E., Lee, B. J., Zhang, Z. C., Fontoura, B. M. A. & Chook, Y. M., May 1 2007, In : Nature Structural and Molecular Biology. 14, 5, p. 452-454 3 p.

Research output: Contribution to journalArticle

106 Scopus citations
2006

Atomic resolution structures in nuclear transport

Süel, K. E., Cansizoglu, A. E. & Chook, Y. M., Aug 1 2006, In : Methods. 39, 4, p. 342-355 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Rules for Nuclear Localization Sequence Recognition by Karyopherinβ2

Lee, B. J., Cansizoglu, A. E., Süel, K. E., Louis, T. H., Zhang, Z. & Chook, Y. M., Aug 4 2006, In : Cell. 126, 3, p. 543-558 16 p.

Research output: Contribution to journalArticle

335 Scopus citations

The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions

Faria, A. M. C., Levay, A., Wang, Y., Kamphorst, A. O., Rosa, M. L. P., Nussenzveig, D. R., Balkan, W., Chook, Y. M., Levy, D. E. & Fontoura, B. M. A., Mar 1 2006, In : Immunity. 24, 3, p. 295-304 10 p.

Research output: Contribution to journalArticle

68 Scopus citations
2004

AMP-activated protein kinase-regulated phosphorylation and acetylation of importin α1: Involvement in the nuclear import of RNA-binding protein HuR

Wang, W., Yang, X., Kawai, T., De Silanes, I. L., Mazan-Mamczarz, K., Chen, P., Yuh, M. C., Quensel, C., Köhler, M. & Gorospe, M., Nov 12 2004, In : Journal of Biological Chemistry. 279, 46, p. 48376-48388 13 p.

Research output: Contribution to journalArticle

99 Scopus citations
2002

Uncoupling Kapβ2 substrate dissociation and ran binding

Chook, Y. M., Jung, A., Rosen, M. K. & Blobel, G., Jun 4 2002, In : Biochemistry. 41, 22, p. 6955-6966 12 p.

Research output: Contribution to journalArticle

43 Scopus citations
1998

Detection and use of pseudo-translation in determination of protein structures

Chook, Y. M., Lipscomb, W. N. & Hengming, K. E., Sep 1 1998, In : Acta Crystallographica Section D: Biological Crystallography. 54, 5, p. 822-827 6 p.

Research output: Contribution to journalArticle

19 Scopus citations
1997

High affinity binding of the pleckstrin homology domain of mSos1 to phosphatidylinositol (4,5)-bisphosphate

Kubiseski, T. J., Chook, Y. M., Parris, W. E., Rozakis-Adcock, M. & Pawson, T., Feb 1 1997, In : Journal of Biological Chemistry. 272, 3, p. 1799-1804 6 p.

Research output: Contribution to journalArticle

63 Scopus citations
1996

The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2

Chook, Y. M., Dec 14 1996, In : Journal of Biological Chemistry. 271, 48, p. 30472-30478 7 p.

Research output: Contribution to journalArticle

61 Scopus citations
1994
154 Scopus citations
1993
Open Access
167 Scopus citations
1991

Escherichia coli aspartate carbamoyltransferase: The probing of crystal structure analysis via site-specific mutagenesis

Stevens, R. C., Chook, Y. M., Cho, C. Y., Lipscomb, W. N. & Kantrowitz, E. R., Apr 1991, In : Protein Engineering, Design and Selection. 4, 4, p. 391-408 18 p.

Research output: Contribution to journalArticle

62 Scopus citations
1990

π-Complexes of Alkenes to Trivalent Aluminum

Chey, J., Choe, H. S., Chook, Y. M., Jensen, E., Seida, P. R. & Francl, M. M., Jan 1 1990, In : Organometallics. 9, 9, p. 2430-2436 7 p.

Research output: Contribution to journalArticle

31 Scopus citations