• 569 Citations
  • 14 h-Index
20062019
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Research Output 2006 2019

  • 569 Citations
  • 14 h-Index
  • 23 Article
2019

Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Singla, A., Fedoseienko, A., Giridharan, S. S. P., Overlee, B. L., Lopez, A., Jia, D., Song, J., Huff-Hardy, K., Weisman, L., Burstein, E. & Billadeau, D. D., Sep 19 2019, In : Nature communications. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Recycling
recycling
phosphates
Membrane Proteins
membranes

SCGN deficiency results in colitis susceptibility

Sifuentes-Dominguez, L., Li, H., Llano, E., Liu, Z., Singla, A., Patel, A. S., Kathania, M., Khoury, A., Norris, N., Rios, J. J., Starokadomskyy, P., Park, J. Y., Gopal, P., Liu, Q., Tan, S., Chan, L., Ross, T., Harrison, S., K, V., Baker, L. A. & 2 others, Jia, D. & Burstein, E., Oct 2019, In : eLife. 8, e49910.

Research output: Contribution to journalArticle

Open Access
Colitis
Inflammatory Bowel Diseases
SNARE Proteins
Enteroendocrine Cells
Hormones
2018
2 Citations (Scopus)

Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation

Miyata, N., Morris, L. L., Chen, Q., Thorne, C., Singla, A., Zhu, W., Winter, M., Melton, S. D., Li, H., Sifuentes-Dominguez, L., Llano, E., Huff-Hardy, K., Starokadomskyy, P., Lopez, A., Reese, T. A., Turer, E., Billadeau, D. D., Winter, S. E. & Burstein, E., Aug 28 2018, In : Cell Reports. 24, 9, p. 2342-2355 14 p.

Research output: Contribution to journalArticle

Myeloid Cells
Prostaglandins
Goblet Cells
Carcinogenesis
Mucous Membrane
2017
57 Citations (Scopus)

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling

McNally, K. E., Faulkner, R., Steinberg, F., Gallon, M., Ghai, R., Pim, D., Langton, P., Pearson, N., Danson, C. M., Nägele, H., Morris, L. L., Singla, A., Overlee, B. L., Heesom, K. J., Sessions, R., Banks, L., Collins, B. M., Berger, I., Billadeau, D. D., Burstein, E. & 1 others, Cullen, P. J., Sep 29 2017, In : Nature Cell Biology. 19, 10, p. 1214-1225 12 p.

Research output: Contribution to journalArticle

Sorting Nexins
Multiprotein Complexes
Recycling
Integrins
Membrane Proteins
2016
27 Citations (Scopus)

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5

Jia, D., Zhang, J. S., Li, F., Wang, J., Deng, Z., White, M. A., Osborne, D. G., Phillips-Krawczak, C., Gomez, T. S., Li, H., Singla, A., Burstein, E., Billadeau, D. D. & Rosen, M. K., Nov 9 2016, In : Nature Communications. 7, 13305.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
proteins
Sorting Nexins
time measurement
membranes
2015
71 Citations (Scopus)

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

Phillips-Krawczak, C. A., Singla, A., Starokadomskyy, P., Deng, Z., Osborne, D. G., Li, H., Dick, C. J., Gomez, T. S., Koenecke, M., Zhang, J. S., Dai, H., Sifuentes-Dominguez, L. F., Geng, L. N., Kaufmann, S. H., Hein, M. Y., Wallis, M., McGaughran, J., Gecz, J., Van De Sluis, B., Billadeau, D. D. & 1 others, Burstein, E., Jan 1 2015, In : Molecular Biology of the Cell. 26, 1, p. 91-103 13 p.

Research output: Contribution to journalArticle

Copper
Endosomes
Homeostasis
Recycling
Actins
2013
11 Citations (Scopus)

CD73 (ecto-5'-nucleotidase) hepatocyte levels differ across mouse strains and contribute to mallory-denk body formation

Snider, N. T., Griggs, N. W., Singla, A., Moons, D. S., Weerasinghe, S. V. W., Lok, A. S., Ruan, C., Burant, C. F., Conjeevaram, H. S. & Omary, M. B., Nov 1 2013, In : Hepatology. 58, 5, p. 1790-1800 11 p.

Research output: Contribution to journalArticle

Mallory Bodies
5'-Nucleotidase
Hepatocytes
Liver
Metabolomics
14 Citations (Scopus)

Lamin aggregation is an early sensor of porphyriainduced liver injury

Singla, A., Griggs, N. W., Kwan, R., Snider, N. T., Maitra, D., Ernst, S. A., Omary, M. B. & Herrmann, H., Jul 1 2013, In : Journal of Cell Science. 126, 14, p. 3105-3112 8 p.

Research output: Contribution to journalArticle

Lamins
Liver
Wounds and Injuries
Mallory Bodies
Ferrochelatase
2012
18 Citations (Scopus)

LPA stimulates intestinal DRA gene transcription via LPA2 receptor, PI3K/AKT, and c-Fos-dependent pathway

Singla, A., Kumar, A., Priyamvada, S., Tahniyath, M., Saksena, S., Gill, R. K., Alrefai, W. A. & Dudeja, P. K., Mar 1 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 6

Research output: Contribution to journalArticle

Lysophosphatidic Acid Receptors
Phosphatidylinositol 3-Kinase
Adenoma
Down-Regulation
Genes
24 Citations (Scopus)

Oxidative stress, Nrf2 and keratin up-regulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria

Singla, A., Moons, D. S., Snider, N. T., Wagenmaker, E. R., Jayasundera, V. B. & Omary, M. B., Jul 1 2012, In : Hepatology. 56, 1, p. 322-331 10 p.

Research output: Contribution to journalArticle

Mallory Bodies
Ferrochelatase
Erythropoietic Protoporphyria
Keratins
Oxidative Stress
2011
9 Citations (Scopus)

Calcitonin receptor-mediated CFTR activation in human intestinal epithelial cells

Liu, H., Singla, A., Ao, M., Gill, R. K., Venkatasubramanian, J., Rao, M. C., Alrefai, W. A. & Dudeja, P. K., Dec 1 2011, In : Journal of Cellular and Molecular Medicine. 15, 12, p. 2697-2705 9 p.

Research output: Contribution to journalArticle

Calcitonin Receptors
Cystic Fibrosis Transmembrane Conductance Regulator
Calcitonin
Epithelial Cells
Chlorides
22 Citations (Scopus)

Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation

Snider, N. T., Weerasinghe, S. V. W., Singla, A., Leonard, J. M., Hanada, S., Andrews, P. C., Lok, A. S. & Omary, M. B., Oct 17 2011, In : Journal of Cell Biology. 195, 2, p. 217-229 13 p.

Research output: Contribution to journalArticle

Nucleoside-Diphosphate Kinase
Glyceraldehyde-3-Phosphate Dehydrogenases
Hepatocytes
Liver
Reactive Oxygen Species
23 Citations (Scopus)

SREBP2 mediates the modulation of intestinal NPC1L1 expression by curcumin

Kumar, P., Malhotra, P., Ma, K., Singla, A., Hedroug, O., Saksena, S., Dudeja, P. K., Gill, R. K. & Alrefai, W. A., Jul 1 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 301, 1

Research output: Contribution to journalArticle

Curcumin
Response Elements
Sterols
Carrier Proteins
Cholesterol
2010
27 Citations (Scopus)

Mechanisms of lysophosphatidic acid (LPA) mediated stimulation of intestinal apical Cl-/OH- exchange

Singla, A., Dwivedi, A., Saksena, S., Gill, R. K., Alrefai, W. A., Ramaswamy, K. & Dudeja, P. K., Feb 1 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 298, 2

Research output: Contribution to journalArticle

Adenoma
Antidiarrheals
Chlorides
Caco-2 Cells
Down-Regulation
36 Citations (Scopus)

Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-γ

Saksena, S., Singla, A., Goyal, S., Katyal, S., Bansal, N., Gill, R. K., Alrefai, W. A., Ramaswamy, K. & Dudeja, P. K., Feb 1 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 298, 2

Research output: Contribution to journalArticle

STAT1 Transcription Factor
Intestines
Anions
Transcription Factors
Gene Expression
2009
36 Citations (Scopus)

Enteropathogenic Escherichia coli Infection Inhibits Intestinal Serotonin Transporter Function and Expression

Esmaili, A., Nazir, S. F., Borthakur, A., Yu, D., Turner, J. R., Saksena, S., Singla, A., Hecht, G. A., Alrefai, W. A. & Gill, R. K., Dec 1 2009, In : Gastroenterology. 137, 6, p. 2074-2083 10 p.

Research output: Contribution to journalArticle

Enteropathogenic Escherichia coli
Escherichia coli Infections
Serotonin Plasma Membrane Transport Proteins
Serotonin
Caco-2 Cells
19 Citations (Scopus)

PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2

Saksena, S., Dwivedi, A., Gill, R. K., Singla, A., Alrefai, W. A., Malakooti, J., Ramaswamy, K. & Dudeja, P. K., Feb 1 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 2

Research output: Contribution to journalArticle

Transcription Factors
Caco-2 Cells
Volatile Fatty Acids
Butyrates
Intestines
2008
14 Citations (Scopus)

Characterization of the 5′-flanking region and regulation of expression of human anion exchanger SLC26A6

Saksena, S., Dwivedi, A., Singla, A., Gill, R. K., Tyagi, S., Borthakur, A., Alrefai, W. A., Ramaswamy, K. & Dudeja, P. K., Oct 1 2008, In : Journal of Cellular Biochemistry. 105, 2, p. 454-466 13 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-1
5' Flanking Region
Gene expression
Interferons
Intestines
2007
50 Citations (Scopus)

Function, expression, and characterization of the serotonin transporter in the native human intestine

Gill, R. K., Pant, N., Saksena, S., Singla, A., Nazir, T. M., Vohwinkel, L., Turner, J. R., Goldstein, J., Alrefai, W. A. & Dudeja, P. K., Dec 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 294, 1

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Population Groups
Intestines
Serotonin
Ileum
26 Citations (Scopus)

Intestinal alkaline phosphatase secretion in oil-fed rats

Kaur, J., Madan, S., Hamid, A., Singla, A. & Mahmood, A., Mar 1 2007, In : Digestive Diseases and Sciences. 52, 3, p. 665-670 6 p.

Research output: Contribution to journalArticle

Alkaline Phosphatase
Oils
Cod Liver Oil
Intestinal Secretions
Serum
78 Citations (Scopus)

Modulation of human Niemann-Pick C1-like 1 gene expression by sterol: Role of sterol regulatory element binding protein 2

Alrefai, W. A., Annaba, F., Sarwar, Z., Dwivedi, A., Saksena, S., Singla, A., Dudeja, P. K. & Gill, R. K., Jan 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 1

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 2
Sterols
Cholesterol
Gene Expression
Caco-2 Cells
2006
1 Citation (Scopus)

Alterations in the expression of intestinal enzymes in rats exposed to nickel

Singla, A., Kaur, J. & Mahmood, A., Sep 1 2006, In : Journal of Applied Toxicology. 26, 5, p. 397-401 5 p.

Research output: Contribution to journalArticle

Brushes
Microvilli
Nickel
Rats
Sucrase
4 Citations (Scopus)
Microvilli
Folic Acid
Membranes
Enzymes
Diet