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External positions

Center for the Genetics of Host Defense

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 26 Similar Profiles
Tumor Necrosis Factor-alpha Medicine & Life Sciences
Toll-Like Receptors Medicine & Life Sciences
Mutation Medicine & Life Sciences
Innate Immunity Medicine & Life Sciences
Lipopolysaccharides Medicine & Life Sciences
Genes Medicine & Life Sciences
Endotoxins Medicine & Life Sciences
Macrophages Medicine & Life Sciences

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Research Output 1974 2019

Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim

Su, L., Wang, Y., Wang, J., Mifune, Y., Morin, M. D., Jones, B. T., Moresco, E. M. Y., Boger, D. L., Beutler, B. A. & Zhang, H., Mar 28 2019, In : Journal of Medicinal Chemistry. 62, 6, p. 2938-2949 12 p.

Research output: Contribution to journalArticle

Ligands
Lipopeptides
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Melanoma
5 Citations (Scopus)

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K. W., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., Ludwig, S., Hildebrand, S., Zhou, K., Siegwart, D. J., Moresco, E. M. Y., Zhang, H., Boger, D. L. & Beutler, B., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8698-E8706

Research output: Contribution to journalArticle

Melanoma
Cytotoxic T-Lymphocytes
Immunization
Toll-Like Receptor 1
Neoplasms
1 Citation (Scopus)

Altered Marginal Zone B Cell Selection in the Absence of i κbNS

Ádori, M., Pedersen, G. K., Ádori, C., Erikson, E., Khoenkhoen, S., Stark, J. M., Choi, J. H., Dosenovic, P., Karlsson, M. C. I., Beutler, B. & Hedestam, G. B. K., Jan 15 2018, In : Journal of Immunology. 200, 2, p. 775-787 13 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Blood-Borne Pathogens
B-Lymphocyte Subsets
Ficoll
B-Lymphoid Precursor Cells

A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis

Turer, E. E., San Miguel, M., Wang, K. W., McAlpine, W., Ou, F., Li, X., Tang, M., Zang, Z., Wang, J., Hayse, B., Evers, B., Zhan, X., Russell, J. L. & Beutler, B. A., Dec 18 2018, In : Disease models & mechanisms. 11, 12

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptor Nuclear Translocator
Medical problems
Clustered Regularly Interspaced Short Palindromic Repeats
Obesity
Mutation
2 Citations (Scopus)

Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists

Morin, M. D., Wang, Y., Jones, B. T., Mifune, Y., Su, L., Shi, H-X., Moresco, E. M. Y., Zhang, H., Beutler, B. A. & Boger, D. L., Jan 1 2018, (Accepted/In press) In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

Dimerization
Toll-Like Receptors
Screening
Toll-Like Receptor 2
Macrophages