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External positions

Center for the Genetics of Host Defense

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 24 Similar Profiles
Tumor Necrosis Factor-alpha Medicine & Life Sciences
Toll-Like Receptors Medicine & Life Sciences
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Genes Medicine & Life Sciences
Endotoxins Medicine & Life Sciences
Macrophages Medicine & Life Sciences

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Research Output 1974 2019

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

Wang, K. W., Zhan, X., McAlpine, W., Zhang, Z., Choi, J. H., Shi, H-X., Misawa, T., Yue, T., Zhang Ph.D., D-W., Wang, Y., Ludwig, S., Russell, J. L., Tang, M., Li, X., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B. A., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11380-11389 10 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Toll-Like Receptors
Regulatory T-Lymphocytes
Colitis
Dendritic Cells

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Choi, J. H., Zhong, X., McAlpine, W., Liao, T. C., Zhang Ph.D., D-W., Fang, B., Russell, J. L., Ludwig, S., Nair-Gill, E., Zhang, Z., Wang, K. W., Misawa, T., Zhan, X., Choi, M., Wang, T., Li, X., Tang, M., Sun, Q., Yu, L., Murray, A. R. & 2 othersMoresco, E. Y. & Beutler, B. A., Jan 1 2019, In : Science. 364, 6440, eaau0812.

Research output: Contribution to journalArticle

Lymphopoiesis
Catenins
Wnt2 Protein
Ethylnitrosourea
Wnt Signaling Pathway

Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim

Su, L., Wang, Y., Wang, J., Mifune, Y., Morin, M. D., Jones, B. T., Moresco, E. M. Y., Boger, D. L., Beutler, B. A. & Zhang, H., Mar 28 2019, In : Journal of Medicinal Chemistry. 62, 6, p. 2938-2949 12 p.

Research output: Contribution to journalArticle

Ligands
Lipopeptides
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Melanoma
7 Citations (Scopus)

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

Wang, Y., Su, L., Morin, M. D., Jones, B. T., Mifune, Y., Shi, H., Wang, K. W., Zhan, X., Liu, A., Wang, J., Li, X., Tang, M., Ludwig, S., Hildebrand, S., Zhou, K., Siegwart, D. J., Moresco, E. M. Y., Zhang, H., Boger, D. L. & Beutler, B., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8698-E8706

Research output: Contribution to journalArticle

Melanoma
Cytotoxic T-Lymphocytes
Immunization
Toll-Like Receptor 1
Neoplasms
1 Citation (Scopus)

Altered Marginal Zone B Cell Selection in the Absence of i κbNS

Ádori, M., Pedersen, G. K., Ádori, C., Erikson, E., Khoenkhoen, S., Stark, J. M., Choi, J. H., Dosenovic, P., Karlsson, M. C. I., Beutler, B. & Hedestam, G. B. K., Jan 15 2018, In : Journal of Immunology. 200, 2, p. 775-787 13 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Blood-Borne Pathogens
B-Lymphocyte Subsets
Ficoll
B-Lymphoid Precursor Cells