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Personal profile

External positions

Center for the Genetics of Host Defense

Fingerprint Dive into the research topics where Bruce A Beutler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 34 Similar Profiles
Tumor Necrosis Factor-alpha Medicine & Life Sciences
Toll-Like Receptors Medicine & Life Sciences
Mutation Medicine & Life Sciences
Innate Immunity Medicine & Life Sciences
Genes Medicine & Life Sciences
Lipopolysaccharides Medicine & Life Sciences
Endotoxins Medicine & Life Sciences
Macrophages Medicine & Life Sciences

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Research Output 1974 2019

Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice

Wang, K. W., Zhan, X., McAlpine, W., Zhang, Z., Choi, J. H., Shi, H., Misawa, T., Yue, T., Zhang Ph.D., D-W., Wang, Y., Ludwig, S., Russell, J., Tang, M., Li, X., Murray, A. R., Moresco, E. M. Y., Turer, E. E. & Beutler, B., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 23, p. 11380-11389 10 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Toll-Like Receptors
Regulatory T-Lymphocytes
Colitis
Dendritic Cells

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Choi, J. H., Zhong, X., McAlpine, W., Liao, T. C., Zhang Ph.D., D-W., Fang, B., Russell, J., Ludwig, S., Nair-Gill, E., Zhang, Z., Wang, K. W., Misawa, T., Zhan, X., Choi, M., Wang, T., Li, X., Tang, M., Sun, Q., Yu, L., Murray, A. R. & 2 others, Moresco, E. Y. & Beutler, B., Jan 1 2019, In : Science. 364, 6440, eaau0812.

Research output: Contribution to journalArticle

Lymphopoiesis
Catenins
Wnt2 Protein
Ethylnitrosourea
Wnt Signaling Pathway
1 Citation (Scopus)

Research Techniques Made Simple: Forward Genetic Screening to Uncover Genes Involved in Skin Biology

McAlpine, W., Russell, J. L., Murray, A. R., Beutler, B. A. & Turer, E. E., Sep 1 2019, In : Journal of Investigative Dermatology. 139, 9, p. 1848-1853.e1

Research output: Contribution to journalShort survey

Genetic Testing
Skin
Screening
Research Design
Genes

Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim

Su, L., Wang, Y., Wang, J., Mifune, Y., Morin, M. D., Jones, B. T., Moresco, E. M. Y., Boger, D. L., Beutler, B. A. & Zhang, H., Mar 28 2019, In : Journal of Medicinal Chemistry. 62, 6, p. 2938-2949 12 p.

Research output: Contribution to journalArticle

Ligands
Lipopeptides
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Melanoma

Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40

Zhang, D., Yue, T., Choi, J. H., Nair-Gill, E., Zhong, X., Wang, K. W., Zhan, X., Li, X., Choi, M., Tang, M., Quan, J., Hildebrand, S., Moresco, E. M. Y. & Beutler, B., Jan 1 2019, (Accepted/In press) In : Nature Immunology.

Research output: Contribution to journalArticle

Spliceosomes
Immune System Diseases
Alleles
Hematopoietic Stem Cells
U5 Small Nuclear Ribonucleoproteins