• 2698 Citations
  • 26 h-Index
20002020

Research output per year

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Research Output

  • 2698 Citations
  • 26 h-Index
  • 56 Article
  • 1 Chapter
  • 1 Review article
2020

High-resolution cryo-EM reconstructions in the presence of substantial aberrations

Bromberg, R., Guo, Y., Borek, D. & Otwinowski, Z., May 1 2020, In : IUCrJ. 7, p. 445-452 8 p.

Research output: Contribution to journalArticle

Open Access

NMR and crystallographic structural studies of the extremely stable monomeric variant of human cystatin C with single amino acid substitution

Maszota-Zieleniak, M., Jurczak, P., Orlikowska, M., Zhukov, I., Borek, D., Otwinowski, Z., Skowron, P., Pietralik, Z., Kozak, M., Szymańska, A. & Rodziewicz-Motowidło, S., Jan 1 2020, In : FEBS Journal. 287, 2, p. 361-376 16 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Divergent kinase regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole

Beraki, T., Hu, X., Broncel, M., Young, J. C., O'Shaughnessy, W. J., Borek, D., Treeck, M. & Reese, M. L., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 13, p. 6361-6370 10 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Inhibition of Marburg Virus RNA Synthesis by a Synthetic Anti-VP35 Antibody

Amatya, P., Wagner, N., Chen, G., Luthra, P., Shi, L., Borek, D., Pavlenco, A., Rohrs, H., Basler, C. F., Sidhu, S. S., Gross, M. L. & Leung, D. W., Aug 9 2019, In : ACS infectious diseases. 5, 8, p. 1385-1396 12 p.

Research output: Contribution to journalArticle

2018

Crystal structure of the human NK1 tachykinin receptor

Yin, J., Chapman, K., Clark, L. D., Shao, Z., Borek, D., Xu, Q., Wang, J. & Rosenbaum, D. M., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. 13264-13269 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Functional diversification of the NleG effector family in enterohemorrhagic Escherichia coli

Valleau, D., Little, D. J., Borek, D., Skarina, T., Quaile, A. T., Leo, R. D., Houliston, S., Lemak, A., Arrowsmith, C. H., Coombes, B. K. & Savchenko, A., Oct 2 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 40, p. 10004-10009 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Real-space analysis of radiation-induced specific changes with independent component analysis

Borek, D., Bromberg, R., Hattne, J. & Otwinowski, Z., Mar 1 2018, In : Journal of Synchrotron Radiation. 25, 2, p. 451-467 17 p.

Research output: Contribution to journalArticle

4 Scopus citations

The Bear Giant-Skipper genome suggests genetic adaptations to living inside yucca roots

Cong, Q., Li, W., Borek, D., Otwinowski, Z. & Grishin, N. V., Jan 1 2018, (Accepted/In press) In : Molecular Genetics and Genomics.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Complete genome of achalarus lyciades, the first representative of the eudaminae subfamily of skippers

Shen, J., Cong, Q., Borek, D., Otwinowski, Z. & Grishin, N. V., Aug 1 2017, In : Current Genomics. 18, 4, p. 366-374 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses

Chatterjee, S., Luthra, P., Esaulova, E., Agapov, E., Yen, B. C., Borek, D. M., Edwards, M. R., Mittal, A., Jordan, D. S., Ramanan, P., Moore, M. L., Pappu, R. V., Holtzman, M. J., Artyomov, M. N., Basler, C. F., Amarasinghe, G. K. & Leung, D. W., Jun 30 2017, In : Nature microbiology. 2, 17101.

Research output: Contribution to journalArticle

7 Scopus citations

The first complete genomes of Metalmarks and the classification of butterfly families

Cong, Q., Shen, J., Li, W., Borek, D., Otwinowski, Z. & Grishin, N. V., 2017, (Accepted/In press) In : Genomics.

Research output: Contribution to journalArticle

8 Scopus citations

When coi barcodes deceive: Complete genomes reveal introgression in hairstreaks

Cong, Q., Shen, J., Borek, D., Robbins, R. K., Opler, P. A., Otwinowski, Z. & Grishin, N. V., Feb 8 2017, In : Proceedings of the Royal Society B: Biological Sciences. 284, 1848, 20161735.

Research output: Contribution to journalArticle

14 Scopus citations
2016

Complete genome of Pieris rapae, a resilient alien, a cabbage pest, and a source of anti-cancer proteins

Grishin, N. V., Shen, J., Cong, Q., Kinch, L. N., Borek, D. & Otwinowski, Z., 2016, In : F1000Research. 5, 2631.

Research output: Contribution to journalArticle

24 Scopus citations

Complete genomes of Hairstreak butterflies, their speciation, and nucleo-mitochondrial incongruence

Cong, Q., Shen, J., Borek, D., Robbins, R. K., Otwinowski, Z. & Grishin, N. V., Apr 28 2016, In : Scientific Reports. 6, 24863.

Research output: Contribution to journalArticle

20 Scopus citations
35 Scopus citations

Crystal structure of the human sterol transporter ABCG5/ABCG8

Lee, J. Y., Kinch, L. N., Borek, D. M., Wang, J., Wang, J., Urbatsch, I. L., Xie, X. S., Grishin, N. V., Cohen, J. C., Otwinowski, Z., Hobbs, H. H. & Rosenbaum, D. M., May 4 2016, In : Nature. 533, 7604, p. 561-564 4 p.

Research output: Contribution to journalArticle

114 Scopus citations

Data publication with the structural biology data grid supports live analysis

Meyer, P. A., Socias, S., Key, J., Ransey, E., Tjon, E. C., Buschiazzo, A., Lei, M., Botka, C., Withrow, J., Neau, D., Rajashankar, K., Anderson, K. S., Baxter, R. H., Blacklow, S. C., Boggon, T. J., Bonvin, A. M. J. J., Borek, D., Brett, T. J., Caflisch, A., Chang, C. I. & 50 others, Chazin, W. J., Corbett, K. D., Cosgrove, M. S., Crosson, S., Dhe-Paganon, S., Di Cera, E., Drennan, C. L., Eck, M. J., Eichman, B. F., Fan, Q. R., Ferré-D'Amaré, A. R., Fromme, J. C., Garcia, K. C., Gaudet, R., Gong, P., Harrison, S. C., Heldwein, E. E., Jia, Z., Keenan, R. J., Kruse, A. C., Kvansakul, M., McLellan, J. S., Modis, Y., Nam, Y., Otwinowski, Z., Pai, E. F., Pereira, P. J. B., Petosa, C., Raman, C. S., Rapoport, T. A., Roll-Mecak, A., Rosen, M. K., Rudenko, G., Schlessinger, J., Schwartz, T. U., Shamoo, Y., Sondermann, H., Tao, Y. J., Tolia, N. H., Tsodikov, O. V., Westover, K. D., Wu, H., Foster, I., Fraser, J. S., Maia, F. R. N. C., Gonen, T., Kirchhausen, T., Diederichs, K., Crosas, M. & Sliz, P., Mar 7 2016, In : Nature communications. 7, 10882.

Research output: Contribution to journalArticle

64 Scopus citations

Speciation in Cloudless Sulphurs Gleaned from Complete Genomes

Cong, Q., Shen, J., Warren, A. D., Borek, D., Otwinowski, Z. & Grishin, N. V., Mar 30 2016, In : Genome Biology and Evolution. 8, 3, p. 915-931 17 p.

Research output: Contribution to journalArticle

27 Scopus citations

Taking a look at the calibration of a CCD detector with a fiber-optic taper

Alkire, R. W., Rotella, F. J., Duke, N. E. C., Otwinowski, Z. & Borek, D., 2016, In : Journal of Applied Crystallography. 49, p. 415-425 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

An intrinsically disordered peptide from ebola virus VP35 controls viral RNA synthesis by modulating nucleoprotein-RNA interactions

Leung, D. W., Borek, D., Luthra, P., Binning, J. M., Anantpadma, M., Liu, G., Harvey, I. B., Su, Z., Endlich-Frazier, A., Pan, J., Shabman, R. S., Chiu, W., Davey, R. A., Otwinowski, Z., Basler, C. F. & Amarasinghe, G. K., Apr 21 2015, In : Cell Reports. 11, 3, p. 376-389 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

Disruption of Wnt/β-catenin signaling and telomeric shortening are inextricable consequences of tankyrase inhibition in human cells

Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L. A., Ma, Z., Wright, W., Chen, C., Shay, J. W., Zhang, X. & Lum, L., 2015, In : Molecular and Cellular Biology. 35, 14, p. 2425-2435 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Skipper genome sheds light on unique phenotypic traits and phylogeny

Cong, Q., Borek, D., Otwinowski, Z. & Grishin, N. V., Aug 27 2015, In : BMC Genomics. 16, 1, 639.

Research output: Contribution to journalArticle

23 Scopus citations

Tiger Swallowtail Genome Reveals Mechanisms for Speciation and Caterpillar Chemical Defense

Cong, Q., Borek, D., Otwinowski, Z. & Grishin, N. V., Feb 17 2015, In : Cell Reports. 10, 6, p. 910-919 10 p.

Research output: Contribution to journalArticle

51 Scopus citations
2014
27 Scopus citations

Crystal structure of active site mutant of antileukemic L-asparaginase reveals conserved zinc-binding site

Borek, D., Kozak, M., Pei, J. & Jaskolski, M., Sep 1 2014, In : The FEBS journal. 281, 18, p. 4097-4111 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1

Xu, W., Edwards, M. R., Borek, D. M., Feagins, A. R., Mittal, A., Alinger, J. B., Berry, K. N., Yen, B., Hamilton, J., Brett, T. J., Pappu, R. V., Leung, D. W., Basler, C. F. & Amarasinghe, G. K., Aug 13 2014, In : Cell Host and Microbe. 16, 2, p. 187-200 14 p.

Research output: Contribution to journalArticle

135 Scopus citations

Extracellular architecture of the SYG-1/SYG-2 adhesion complex instructs synaptogenesis

Özkan, E., Chia, P. H., Wang, R. R., Goriatcheva, N., Borek, D., Otwinowski, Z., Walz, T., Shen, K. & Garcia, K. C., Jan 30 2014, In : Cell. 156, 3, p. 482-494 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity

Brown, C. S., Lee, M. S., Leung, D. W., Wang, T., Xu, W., Luthra, P., Anantpadma, M., Shabman, R. S., Melito, L. M., Macmillan, K. S., Borek, D. M., Otwinowski, Z., Ramanan, P., Stubbs, A. J., Peterson, D. S., Binning, J. M., Tonelli, M., Olson, M. A., Davey, R. A., Ready, J. M. & 2 others, Basler, C. F. & Amarasinghe, G. K., May 15 2014, In : Journal of Molecular Biology. 426, 10, p. 2045-2058 14 p.

Research output: Contribution to journalArticle

42 Scopus citations
2013

Development of RNA aptamers targeting Ebola virus VP35

Binning, J. M., Wang, T., Luthra, P., Shabman, R. S., Borek, D. M., Liu, G., Xu, W., Leung, D. W., Basler, C. F. & Amarasinghe, G. K., Nov 26 2013, In : Biochemistry. 52, 47, p. 8406-8419 14 p.

Research output: Contribution to journalArticle

46 Scopus citations

Everything happens at once - Deconvolving systematic effects in X-ray data processing

Borek, D. & Otwinowski, Z., May 8 2013, Advancing Methods for Biomolecular Crystallography. Randy, R., Urzhumtsev, A., Alexandre, U. & Lunin, V. (eds.). p. 105-112 8 p. (NATO Science for Peace and Security Series A: Chemistry and Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Identification of patterns in diffraction intensities affected by radiation exposure

Borek, D., Dauter, Z. & Otwinowski, Z., Jan 1 2013, In : Journal of Synchrotron Radiation. 20, 1, p. 37-48 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Structural characterization of V57D and V57P mutants of human cystatin C, an amyloidogenic protein

Orlikowska, M., Szymańska, A., Borek, D., Otwinowski, Z., Skowron, P. & Jankowska, E., Apr 1 2013, In : Acta Crystallographica Section D: Biological Crystallography. 69, 4, p. 577-586 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structure of the human cohesin inhibitor Wapl

Ouyang, Z., Zheng, G., Song, J., Borek, D., Otwinowski, Z., Brautigam, C. A., Tomchick, D. R., Rankin, S. & Yu, H., Jul 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 28, p. 11355-11360 6 p.

Research output: Contribution to journalArticle

41 Scopus citations
2012

Structural basis for Marburg virus VP35–mediated immune evasion mechanisms

Ramanan, P., Edwards, M. R., Shabman, R. S., Leung, D. W., Endlich-Frazier, A. C., Borek, D. M., Otwinowski, Z., Liu, G., Huh, J., Basler, C. F. & Amarasinghe, G. K., Dec 11 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 50, p. 20661-20666 6 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Structure of the Type III Secretion Effector Protein ExoU in Complex with Its Chaperone SpcU

Halavaty, A. S., Borek, D., Tyson, G. H., Veesenmeyer, J. L., Shuvalova, L., Minasov, G., Otwinowski, Z., Hauser, A. R. & Anderson, W. F., Nov 14 2012, In : PloS one. 7, 11, e49388.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Crystallization and preliminary X-ray diffraction analysis of Val57 mutants of the amyloidogenic protein human cystatin C

Orlikowska, M., Jankowska, E., Borek, D., Otwinowski, Z., Skowron, P. & Szymaska, A., Dec 1 2011, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 67, 12, p. 1608-1611 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation

Li, A. Y., Lee, J., Borek, D., Otwinowski, Z., Tibbits, G. F. & Paetzel, M., Oct 28 2011, In : Journal of Molecular Biology. 413, 3, p. 699-711 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
2010

Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins

Leung, D. W., Borek, D., Farahbakhsh, M., Ramanan, P., Nix, J. C., Wang, T., Prins, K. C., Otwinowski, Z., Honzatko, R. B., Helgeson, L. A., Basler, C. F. & Amarasinghe, G. K., Jun 10 2010, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 66, 6, p. 689-692 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Diffraction data analysis in the presence of radiation damage

Borek, D., Cymborowski, M., MacHius, M., Minor, W. & Otwinowski, Z., Apr 19 2010, In : Acta Crystallographica Section D: Biological Crystallography. 66, 4, p. 426-436 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Structural and functional characterization of Reston Ebola virus VP35 interferon inhibitory domain

Leung, D. W., Shabman, R. S., Farahbakhsh, M., Prins, K. C., Borek, D. M., Wang, T., Mühlberger, E., Basler, C. F. & Amarasinghe, G. K., Jun 2010, In : Journal of Molecular Biology. 399, 3, p. 347-357 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

Leung, D. W., Prins, K. C., Borek, D. M., Farahbakhsh, M., Tufariello, J. M., Ramanan, P., Nix, J. C., Helgeson, L. A., Otwinowski, Z., Honzatko, R. B., Basler, C. F. & Amarasinghe, G. K., Feb 1 2010, In : Nature Structural and Molecular Biology. 17, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

125 Scopus citations

Structure and control of the actin regulatory WAVE complex

Chen, Z., Borek, D., Padrick, S. B., Gomez, T. S., Metlagel, Z., Ismail, A. M., Umetani, J., Billadeau, D. D., Otwinowski, Z. & Rosen, M. K., Nov 25 2010, In : Nature. 468, 7323, p. 533-538 6 p.

Research output: Contribution to journalArticle

240 Scopus citations

To automate or not to automate: This is the question

Cymborowski, M., Klimecka, M., Chruszcz, M., Zimmerman, M. D., Shumilin, I. A., Borek, D., Lazarski, K., Joachimiak, A., Otwinowski, Z., Anderson, W. & Minor, W., Sep 1 2010, In : Journal of Structural and Functional Genomics. 11, 3, p. 211-221 11 p.

Research output: Contribution to journalReview article

20 Scopus citations
2009

Structure and Mechanism of a Eukaryotic FMN Adenylyltransferase

Huerta, C., Borek, D., Machius, M., Grishin, N. V. & Zhang, H., Jun 5 2009, In : Journal of Molecular Biology. 389, 2, p. 388-400 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

X-ray diffraction experiment--the last experiment in the structure elucidation process.

Chruszcz, M., Borek, D., Domagalski, M., Otwinowski, Z. & Minor, W., 2009, In : Advances in Protein Chemistry and Structural Biology. 77, p. 23-40 18 p.

Research output: Contribution to journalArticle

6 Scopus citations
2008

Crystal packing of plant-type L-asparaginase from Escherichia coli

Michalska, K., Borek, D., Hernändez-Santoyo, A. & Jaskolski, M., Feb 20 2008, In : Acta Crystallographica Section D: Biological Crystallography. 64, 3, p. 309-320 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Crystal structure and putative function of small Toprim domain-containing protein from Bacillus stearothermophilus

Řezáčová, P., Borek, D., Moy, S. F., Joachimiak, A. & Otwinowski, Z., Feb 1 2008, In : Proteins: Structure, Function and Genetics. 70, 2, p. 311-319 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2007

The crystal structure of the effector-binding domain of the trehalose repressor TreR from Bacillus subtilis 168 reveals a unique quarternary assembly

Řezáčová, P., Krejčiříková, V., Borek, D., Moy, S. F., Joachimiak, A. & Otwinowski, Z., Nov 15 2007, In : Proteins: Structure, Function and Genetics. 69, 3, p. 679-682 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

The many faces of radiation-induced changes

Borek, D., Ginell, S. L., Cymborowski, M., Minor, W. & Otwinowski, Z., Jan 1 2007, In : Journal of Synchrotron Radiation. 14, 1, p. 24-33 10 p.

Research output: Contribution to journalArticle

44 Scopus citations
2006

Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase

Yang, M., Gocke, C. B., Luo, X., Borek, D., Tomchick, D. R., Machius, M., Otwinowski, Z. & Yu, H., Aug 4 2006, In : Molecular cell. 23, 3, p. 377-387 11 p.

Research output: Contribution to journalArticle

208 Scopus citations