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Fingerprint Dive into the research topics where Erdal Toprak is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Microbial Drug Resistance Medicine & Life Sciences
Tetrahydrofolate Dehydrogenase Medicine & Life Sciences
Anti-Bacterial Agents Medicine & Life Sciences
Trimethoprim Medicine & Life Sciences
Biophysics Medicine & Life Sciences
Optical Imaging Medicine & Life Sciences
antibiotics Agriculture & Biology
Pharmaceutical Preparations Medicine & Life Sciences

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Research Output 2006 2019

  • 1253 Citations
  • 15 h-Index
  • 21 Article
  • 1 Book
  • 1 Comment/debate
  • 1 Short survey

High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection

Tamer, Y. T., Gaszek, I. K., Abdizadeh, H., Batur, T. A., Reynolds, K. A., Atilgan, A. R., Atilgan, C. & Toprak, E., Jul 1 2019, In : Molecular biology and evolution. 36, 7, p. 1533-1550 18 p.

Research output: Contribution to journalArticle

Open Access
dihydrofolate reductase
epistasis
Tetrahydrofolate Dehydrogenase
Trimethoprim
trimethoprim

Non-antibiotic Small-Molecule Regulation of DHFR-Based Destabilizing Domains In Vivo

Peng, H., Chau, V. Q., Phetsang, W., Sebastian, R. M., Stone, M. R. L., Datta, S., Renwick, M., Tamer, Y. T., Toprak, E., Koh, A., Blaskovich, M. A. T. & Hulleman, J. D., Dec 13 2019, In : Molecular Therapy - Methods and Clinical Development. 15, p. 27-39 13 p.

Research output: Contribution to journalArticle

Open Access
Tetrahydrofolate Dehydrogenase
Trimethoprim
Blood-Retinal Barrier
Proteins
Microbial Drug Resistance

Rapid ultrasensitive detection platform for antimicrobial susceptibility testing

Cansizoglu, M. F., Tamer, Y. T., Farid, M., Koh, A. & Toprak, E., May 1 2019, In : PLoS biology. 17, 5, p. e3000291

Research output: Contribution to journalArticle

Open Access
detectors
anti-infective agents
Anti-Bacterial Agents
Detectors
antibiotics
9 Citations (Scopus)

Fighting against evolution of antibiotic resistance by utilizing evolvable antimicrobial drugs

Cansizoglu, M. F. & Toprak, E., May 11 2017, (Accepted/In press) In : Current Genetics. p. 1-4 4 p.

Research output: Contribution to journalArticle

Microbial Drug Resistance
Anti-Infective Agents
Pharmaceutical Preparations
Bacteria
Bacterial Genes
5 Citations (Scopus)

Increased substrate affinity in the Escherichia coli L28R dihydrofolate reductase mutant causes trimethoprim resistance

Abdizadeh, H., Tamer, Y. T., Acar, O., Toprak, E., Atilgan, A. R. & Atilgan, C., 2017, In : Physical Chemistry Chemical Physics. 19, 18, p. 11416-11428 13 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Trimethoprim
Escherichia
Escherichia coli
affinity