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Research Output

  • 3902 Citations
  • 19 h-Index
  • 38 Article
  • 3 Review article
  • 1 Letter
2020

Clinical exome studies have inconsistent coverage

Gotway, G., Crossley, E., Kozlitina, J., Xing, C., Fan, J., Hornbuckle, C., Thies, J., Michel, D., Quinn, C., Scheuerle, A. E., Umana, L. A., Uhles, C. L. & Park, J. Y., 2020, In : Clinical chemistry. 66, 1, p. 199-206 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Genetic Risk Factors and Disease Modifiers of Nonalcoholic Steatohepatitis

Kozlitina, J., Mar 2020, In : Gastroenterology Clinics of North America. 49, 1, p. 25-44 20 p.

Research output: Contribution to journalReview article

Prevalence of pectus excavatum in an adult population-based cohort estimated from radiographic indices of chest wall shape

Biavati, M., Kozlitina, J., Alder, A. C., Foglia, R., McColl, R. W., Peshock, R. M., Kelly, R. E. & Garcia, C. K., May 2020, In : PloS one. 15, 5, e0232575.

Research output: Contribution to journalArticle

Open Access
2019

An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking

Kozlitina, J., Risso, D., Lansu, K., Olsen, R. H. J., Sainz, E., Luiselli, D., Barik, A., Frigerio-Domingues, C., Pagani, L., Wooding, S. P., Kirchner, T., Niaura, R., Roth, B. & Drayna, D., Feb 2019, In : PLoS genetics. 15, 2, e1007916.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients

Dongiovanni, P., Meroni, M., Baselli, G., Mancina, R. M., Ruscica, M., Longo, M., Rametta, R., Cespiati, A., Pelusi, S., Ferri, N., Ranzani, V., Nobili, V., Pihlajamaki, J., Fracanzani, A. L., Badiali, S., Petta, S., Fargion, S., Romeo, S., Kozlitina, J. & Valenti, L., 2019, In : Journal of lipid research. 60, 6, p. 1144-1153 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Telomere length and genetic variant associations with interstitial lung disease progression and survival

Newton, C. A., Oldham, J. M., Ley, B., Anand, V., Adegunsoye, A., Liu, G., Batra, K., Torrealba, J., Kozlitina, J., Glazer, C., Strek, M. E., Wolters, P. J., Noth, I. & Garcia, C. K., Apr 1 2019, In : The European respiratory journal. 53, 4

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Telomere Length and Use of Immunosuppressive Medications in Idiopathic Pulmonary Fibrosis

Newton, C. A., Zhang, D., Oldham, J. M., Kozlitina, J., Ma, S. F., Martinez, F. J., Raghu, G., Noth, I. & Garcia, C. K., Aug 1 2019, In : American journal of respiratory and critical care medicine. 200, 3, p. 336-347 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2018

A GTPase-activating protein– binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells

Ramachandran, B., Stabley, J. N., Cheng, S. L., Behrmann, A. S., Gay, A., Li, L., Mead, M., Kozlitina, J., Lemoff, A., Mirzaei, H., Chen, Z. & Towler, D. A., May 25 2018, In : Journal of Biological Chemistry. 293, 21, p. 7942-7968 27 p.

Research output: Contribution to journalArticle

9 Scopus citations

A protein-truncating HSD17B13 variant and protection from chronic liver disease

Abul-Husn, N. S., Cheng, X., Li, A. H., Xin, Y., Schurmann, C., Stevis, P., Liu, Y., Kozlitina, J., Stender, S., Wood, G. C., Stepanchick, A. N., Still, M. D., McCarthy, S., O'Dushlaine, C., Packer, J. S., Balasubramanian, S., Gosalia, N., Esopi, D., Kim, S. Y., Mukherjee, S. & 28 others, Lopez, A. E., Fuller, E. D., Penn, J., Chu, X., Luo, J. Z., Mirshahi, U. L., Carey, D. J., Still, C. D., Feldman, M. D., Small, A., Damrauer, S. M., Rader, D. J., Zambrowicz, B., Olson, W., Murphy, A. J., Borecki, I. B., Shuldiner, A. R., Reid, J. G., Overton, J. D., Yancopoulos, G. D., Hobbs, H. H., Cohen, J. C., Gottesman, O., Teslovich, T. M., Baras, A., Mirshahi, T., Gromada, J. & Dewey, F. E., Mar 22 2018, In : New England Journal of Medicine. 378, 12, p. 1096-1106 11 p.

Research output: Contribution to journalArticle

138 Scopus citations
5 Scopus citations

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

Dongiovanni, P., Stender, S., Pietrelli, A., Mancina, R. M., Cespiati, A., Petta, S., Pelusi, S., Pingitore, P., Badiali, S., Maggioni, M., Mannisto, V., Grimaudo, S., Pipitone, R. M., Pihlajamaki, J., Craxi, A., Taube, M., Carlsson, L. M. S., Fargion, S., Romeo, S., Kozlitina, J. & 1 others, Valenti, L., Apr 1 2018, In : Journal of Internal Medicine. 283, 4, p. 356-370 15 p.

Research output: Contribution to journalArticle

64 Scopus citations

HSD17B13 and chronic liver disease in blacks and Hispanics

Kozlitina, J., Stender, S., Hobbs, H. H. & Cohen, J. C., Nov 8 2018, In : New England Journal of Medicine. 379, 19, p. 1876-1877 2 p.

Research output: Contribution to journalLetter

10 Scopus citations

Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study

Neeland, I. J., Singh, S., McGuire, D. K., Vega, G. L., Roddy, T., Reilly, D. F., Castro-Perez, J., Kozlitina, J. & Scherer, P. E., Jan 1 2018, (Accepted/In press) In : Diabetologia.

Research output: Contribution to journalArticle

14 Scopus citations
2017

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

Stender, S., Kozlitina, J., Nordestgaard, B. G., Tybjærg-Hansen, A., Hobbs, H. H. & Cohen, J. C., Jun 1 2017, In : Nature Genetics. 49, 6, p. 842-847 6 p.

Research output: Contribution to journalArticle

94 Scopus citations
10 Scopus citations
29 Scopus citations

Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin

Chakrabarti, R. S., Ingham, S. A., Kozlitina, J., Gay, A., Cohen, J. C., Radhakrishnan, A. & Hobbs, H. H., Feb 8 2017, In : eLife. 6, e23355.

Research output: Contribution to journalArticle

14 Scopus citations
2016

Association Between Sedentary Time and Coronary Artery Calcium

Kulinski, J. P., Kozlitina, J., Berry, J. D., de Lemos, J. A. & Khera, A., 2016, (Accepted/In press) In : JACC: Cardiovascular Imaging.

Research output: Contribution to journalArticle

1 Scopus citations

Caspase-12, but not caspase-11, inhibits obesity and insulin resistance

Skeldon, A. M., Morizot, A., Douglas, T., Santoro, N., Kursawe, R., Kozlitina, J., Caprio, S., Mehal, W. Z. & Saleh, M., Jan 1 2016, In : Journal of Immunology. 196, 1, p. 437-447 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genetic variation in the TAS2R38 bitter taste receptor and smoking behaviors

Risso, D. S., Kozlitina, J., Sainz, E., Gutierrez, J., Wooding, S., Getachew, B., Luiselli, D., Berg, C. J. & Drayna, D., Oct 1 2016, In : PLoS One. 11, 10, e0164157.

Research output: Contribution to journalArticle

11 Scopus citations

Plasma Levels of Risk-Variant APOL1 Do Not Associate with Renal Disease in a Population-Based Cohort

Kozlitina, J., Zhou, H., Brown, P. N., Rohm, R. J., Pan, Y., Ayanoglu, G., Du, X., Rimmer, E., Reilly, D. F., Roddy, T. P., Cully, D. F., Vogt, T. F., Blom, D. & Hoek, M., Oct 1 2016, In : Journal of the American Society of Nephrology : JASN. 27, 10, p. 3204-3219 16 p.

Research output: Contribution to journalArticle

35 Scopus citations

Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive

Newton, C. A., Batra, K., Torrealba, J., Kozlitina, J., Glazer, C. S., Aravena, C., Meyer, K., Raghu, G., Collard, H. R. & Garcia, C. K., Dec 1 2016, In : European Respiratory Journal. 48, 6, p. 1710-1720 11 p.

Research output: Contribution to journalArticle

82 Scopus citations

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

Mancina, R. M., Dongiovanni, P., Petta, S., Pingitore, P., Meroni, M., Rametta, R., Borén, J., Montalcini, T., Pujia, A., Wiklund, O., Hindy, G., Spagnuolo, R., Motta, B. M., Pipitone, R. M., Craxì, A., Fargion, S., Nobili, V., Käkelä, P., Kärjä, V., Männistö, V. & 6 others, Pihlajamäki, J., Reilly, D. F., Castro-Perez, J., Kozlitina, J., Valenti, L. & Romeo, S., May 1 2016, In : Gastroenterology. 150, 5, p. 1219-1230e6

Research output: Contribution to journalArticle

189 Scopus citations
2015

A robust distribution-free test for genetic association studies of quantitative traits

Kozlitina, J. & Schucany, W. R., Nov 1 2015, In : Statistical Applications in Genetics and Molecular Biology. 14, 5, p. 443-464 22 p.

Research output: Contribution to journalArticle

3 Scopus citations

Erratum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome (Nature (2015) 521 (E1-E4) DOI:10.1038/nature14444)

Wang, J., Wegener, J. E., Huang, T. W., Sripathy, S., De Jesus-Cortes, H., Xu, P., Tran, S., Knobbe, W., Leko, V., Britt, J., Starwalt, R., McDaniel, L., Ward, C. S., Parra, D., Newcomb, B., Lao, U., Nourigat, C., Flowers, D. A., Cullen, S., Jorstad, N. L. & 20 others, Yang, Y., Glaskova, L., Vigneau, S., Kozlitina, J., Yetman, M. J., Jankowsky, J. L., Reichardt, S. D., Reichardt, H. M., Gartner, J., Bartolomei, M. S., Fang, M., Loeb, K., Keene, C. D., Bernstein, I., Goodell, M., Brat, D. J., Huppke, P., Neul, J. L., Bedalov, A. & Pieper, A. A., Sep 24 2015, In : Nature. 525, 7570, p. 552 1 p.

Research output: Contribution to journalArticle

Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

Wang, J., Wegener, J. E., Huang, T. W., Sripathy, S., De Jesus-Cortes, H., Xu, P., Tran, S., Knobbe, W., Leko, V., Britt, J., Starwalt, R., McDaniel, L., Ward, C. S., Parra, D., Newcomb, B., Lao, U., Nourigat, C., Flowers, D. A., Cullen, S., Jorstad, N. L. & 20 others, Yang, Y., Glaskova, L., Vigneau, S., Kozlitina, J., Yetman, M. J., Jankowsky, J. L., Reichardt, S. D., Reichardt, H. M., Gärtner, J., Bartolomei, M. S., Fang, M., Loeb, K., Keene, C. D., Bernstein, I., Goodell, M., Brat, D. J., Huppke, P., Neul, J. L., Bedalov, A. & Pieper, A. A., May 20 2015, In : Nature. 521, 7552, p. E1-E4

Research output: Contribution to journalArticle

72 Scopus citations
2014

Effect of leukocyte telomere length on total and regional brain volumes in a large population-based cohort

King, K. S., Kozlitina, J., Rosenberg, R. N., Peshock, R. M., McColl, R. W. & Garcia, C. K., Oct 1 2014, In : JAMA neurology. 71, 10, p. 1247-1254 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Effect of telomere length on survival in patients with idiopathic pulmonary fibrosis: An observational cohort study with independent validation

Stuart, B. D., Lee, J. S., Kozlitina, J., Noth, I., Devine, M. S., Glazer, C. S., Torres, F., Kaza, V., Girod, C. E., Jones, K. D., Elicker, B. M., Ma, S. F., Vij, R., Collard, H. R., Wolters, P. J. & Garcia, C. K., Jul 2014, In : The Lancet Respiratory Medicine. 2, 7, p. 557-565 9 p.

Research output: Contribution to journalArticle

113 Scopus citations

Ethnic differences in physical activity and metabolic risk: The dallas heart study

Lakoski, S. G. & Kozlitina, J., Jun 2014, In : Medicine and science in sports and exercise. 46, 6, p. 1124-1132 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

Kozlitina, J., Smagris, E., Stender, S., Nordestgaard, B. G., Zhou, H. H., Tybjærg-Hansen, A., Vogt, T. F., Hobbs, H. H. & Cohen, J. C., Apr 2014, In : Nature genetics. 46, 4, p. 352-356 5 p.

Research output: Contribution to journalArticle

447 Scopus citations

Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels

Stiles, A. R., Kozlitina, J., Thompson, B. M., McDonald, J. G., King, K. S. & Russell, D. W., Sep 23 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 38, p. E4006-E4014

Research output: Contribution to journalArticle

38 Scopus citations

Inducible neuronal inactivation of Sim1 in adult mice causes hyperphagic obesity

Tolson, K. P., Gemelli, T., Meyer, D., Yazdani, U., Kozlitina, J. & Zinn, A. R., Jul 2014, In : Endocrinology. 155, 7, p. 2436-2444 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013

Frequency of the cholesteryl ester storage disease common LIPA E8SJM mutation (c.894G>A) in various racial and ethnic groups

Scott, S. A., Liu, B., Nazarenko, I., Martis, S., Kozlitina, J., Yang, Y., Ramirez, C., Kasai, Y., Hyatt, T., Peter, I. & Desnick, R. J., Sep 1 2013, In : Hepatology. 58, 3, p. 958-965 8 p.

Research output: Contribution to journalArticle

68 Scopus citations
2012

Atypical angiopoietin-like protein that regulates ANGPTL3

Quagliarini, F., Wang, Y., Kozlitina, J., Grishin, N. V., Hyde, R., Boerwinkle, E., Valenzuela, D. M., Murphy, A. J., Cohen, J. C. & Hobbs, H. H., Nov 27 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19751-19756 6 p.

Research output: Contribution to journalArticle

239 Scopus citations

Red Blood Cell Size Is Inversely Associated with Leukocyte Telomere Length in a Large Multi-Ethnic Population

Kozlitina, J. & Garcia, C. K., Dec 4 2012, In : PloS one. 7, 12, e51046.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance

Kozlitina, J., Boerwinkle, E., Cohen, J. C. & Hobbs, H. H., Feb 1 2011, In : Hepatology. 53, 2, p. 467-474 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

Minimum Information about a Genotyping Experiment (MIGEN)

Huang, J., Mirel, D., Pugh, E., Xing, C., Robinson, P. N., Pertsemlidis, A., Ding, L., Kozlitina, J., Maher, J., Rios, J., Story, M., Marthandan, N. & Scheuermann, R. H., Dec 15 2011, In : Standards in Genomic Sciences. 5, 2, p. 224-229 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Population-based risk assessment of APOL1 on renal disease

Friedman, D. J., Kozlitina, J., Genovese, G., Jog, P. & Pollak, M. R., Nov 1 2011, In : Journal of the American Society of Nephrology. 22, 11, p. 2098-2105 8 p.

Research output: Contribution to journalArticle

138 Scopus citations
2010

Power of Genetic Association Studies with Fixed and Random Genotype Frequencies

Kozlitina, J., Xing, C., Pertsemlidis, A. & Schucany, W. R., Sep 1 2010, In : Annals of Human Genetics. 74, 5, p. 429-438 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2009

Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans

Romeo, S., Yin, W., Kozlitina, J., Pennacchio, L. A., Boerwinkle, E., Hobbs, H. H. & Cohen, J. C., Jan 5 2009, In : Journal of Clinical Investigation. 119, 1, p. 70-79 10 p.

Research output: Contribution to journalArticle

260 Scopus citations
2008

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C. & Hobbs, H. H., Dec 1 2008, In : Nature genetics. 40, 12, p. 1461-1465 5 p.

Research output: Contribution to journalArticle

1577 Scopus citations
2006

Efficient survey sampling of households via Gaussian quadrature

Arndt, C., Kozlitina, J. & Preckel, P. V., May 1 2006, In : Journal of the Royal Statistical Society. Series C: Applied Statistics. 55, 3, p. 355-364 10 p.

Research output: Contribution to journalReview article

9 Scopus citations