• 577 Citations
  • 10 h-Index
20002020

Research output per year

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Research Output

  • 577 Citations
  • 10 h-Index
  • 15 Article
  • 2 Chapter
  • 2 Short survey
  • 1 Review article
2020

Strategies for Engineering and Rewiring Kinase Regulation

McCormick, J. W., Pincus, D., Resnekov, O. & Reynolds, K. A., Mar 2020, In : Trends in biochemical sciences. 45, 3, p. 259-271 13 p.

Research output: Contribution to journalReview article

2019

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism

Schober, A. F., Mathis, A. D., Ingle, C., Park, J. O., Chen, L., Rabinowitz, J. D., Junier, I., Rivoire, O. & Reynolds, K. A., Jun 11 2019, In : Cell Reports. 27, 11, p. 3359-3370.e7

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

High-order epistasis in catalytic power of dihydrofolate reductase gives rise to a rugged fitness landscape in the presence of trimethoprim selection

Tamer, Y. T., Gaszek, I. K., Abdizadeh, H., Batur, T. A., Reynolds, K. A., Atilgan, A. R., Atilgan, C. & Toprak, E., 2019, In : Molecular biology and evolution. 36, 7, p. 1533-1550 18 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

An evolutionary hotspot defines functional differences between CRYPTOCHROMES

Rosensweig, C., Reynolds, K. A., Gao, P., Laothamatas, I., Shan, Y., Ranganathan, R., Takahashi, J. S. & Green, C. B., Dec 1 2018, In : Nature Communications. 9, 1, 1138.

Research output: Contribution to journalArticle

21 Scopus citations

Engineering allosteric regulation in protein kinases

Pincus, D., Pandey, J. P., Feder, Z. A., Creixell, P., Resnekov, O. & Reynolds, K. A., Nov 6 2018, In : Science Signaling. 11, 555, eaar3250.

Research output: Contribution to journalArticle

7 Scopus citations
2017

An evolution-based strategy for engineering allosteric regulation

Pincus, D., Resnekov, O. & Reynolds, K. A., Apr 28 2017, In : Physical Biology. 14, 2, 025002.

Research output: Contribution to journalArticle

8 Scopus citations

Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily

Narayanan, C., Gagné, D., Reynolds, K. A. & Doucet, N., Dec 1 2017, In : Scientific reports. 7, 1, 3207.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Evolution-Based Functional Decomposition of Proteins

Rivoire, O., Reynolds, K. A. & Ranganathan, R., Jun 2016, In : PLoS Computational Biology. 12, 6, e1004817.

Research output: Contribution to journalArticle

31 Scopus citations
2015

A new test of computational protein design: Predicting posttranslational modification specificity for the enzyme SMYD2

Reynolds, K. A., Jan 6 2015, In : Structure. 23, 1, p. 11-12 2 p.

Research output: Contribution to journalShort survey

2014

Finding a common path: Predicting gene function using inferred evolutionary trees

Reynolds, K. A., Jul 14 2014, In : Developmental Cell. 30, 1, p. 4-5 2 p.

Research output: Contribution to journalShort survey

2013

Evolution-based design of proteins

Reynolds, K. A., Russ, W. P., Socolich, M. & Ranganathan, R., 2013, Methods in Protein Design. Academic Press Inc., p. 213-235 23 p. (Methods in Enzymology; vol. 523).

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations
2011

Hot spots for allosteric regulation on protein surfaces

Reynolds, K. A., McLaughlin, R. N. & Ranganathan, R., Dec 23 2011, In : Cell. 147, 7, p. 1564-1575 12 p.

Research output: Contribution to journalArticle

177 Scopus citations

Specificity and cooperativity at β-lactamase position 104 in TEM-1/BLIP and SHV-1/BLIP interactions

Hanes, M. S., Reynolds, K. A., Mcnamara, C., Ghosh, P., Bonomo, R. A., Kirsch, J. F. & Handel, T. M., Apr 1 2011, In : Proteins: Structure, Function and Bioinformatics. 79, 4, p. 1267-1276 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2010

Structure and Modeling of GPCRs: Implications for Drug Discovery

Reynolds, K. A., Katritch, V. & Abagyan, R., Jul 15 2010, GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions. John Wiley and Sons, p. 385-433 49 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations
2009

Analysis of full and partial agonists binding to β2- adrenergic receptor suggests a role of transmembrane helix v in agonist-specific conformational changes

Katritch, V., Reynolds, K. A., Cherezov, V., Hanson, M. A., Roth, C. B., Yeager, M. & Abagyan, R., Jul 1 2009, In : Journal of Molecular Recognition. 22, 4, p. 307-318 12 p.

Research output: Contribution to journalArticle

94 Scopus citations
55 Scopus citations
2008

Computational Redesign of the SHV-1 β-Lactamase/β-Lactamase Inhibitor Protein Interface

Reynolds, K. A., Hanes, M. S., Thomson, J. M., Antczak, A. J., Berger, J. M., Bonomo, R. A., Kirsch, J. F. & Handel, T. M., Oct 24 2008, In : Journal of Molecular Biology. 382, 5, p. 1265-1275 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2007

An object-oriented library for computational protein design

Chowdry, A. B., Reynolds, K. A., Hanes, M. S., Voorhies, M., Pokala, N. & Handel, T. M., Nov 15 2007, In : Journal of Computational Chemistry. 28, 14, p. 2378-2388 11 p.

Research output: Contribution to journalArticle

30 Scopus citations
2006

Structural and computational characterization of the SHV-1 β-lactamase-β-lactamase inhibitor protein interface

Reynolds, K. A., Thomson, J. M., Corbett, K. D., Bethel, C. R., Berger, J. M., Kirsch, J. F., Bonomo, R. A. & Handel, T. M., Sep 8 2006, In : Journal of Biological Chemistry. 281, 36, p. 26745-26753 9 p.

Research output: Contribution to journalArticle

40 Scopus citations
2000

Cloning and characterization of the Dictyostelium discoideum cycloartenol synthase cDNA

Godzina, S. M., Lovato, M. A., Meyer, M. M., Foster, K. A., Wilson, W. K., Gu, W., De Hostos, E. L. & Matsuda, S. P. T., Jan 1 2000, In : Lipids. 35, 3, p. 249-255 7 p.

Research output: Contribution to journalArticle

24 Scopus citations