Noelle S Williams

  • 5551 Citations
  • 37 h-Index
1989 …2019
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Research Output 1989 2019

  • 5551 Citations
  • 37 h-Index
  • 88 Article
  • 1 Chapter
  • 1 Review article
2019
1 Citation (Scopus)
Adenomatous Polyposis Coli
Colorectal Neoplasms
Cell Line
Colonic Neoplasms
Mutation
7 Citations (Scopus)

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

Shi, Y., Lim, S. K., Liang, Q., Iyer, S. V., Wang, H. Y., Wang, Z., Xie, X., Sun, D., Chen, Y. J., Tabar, V., Gutin, P., Williams, N. S., De Brabander, J. K. & Parada, L. F., Mar 21 2019, In : Nature. 567, 7748, p. 341-346 6 p.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Glioblastoma
Neoplasms
Proton-Translocating ATPases
Mitochondrial Membranes

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer

Venkateswaran, N., Lafita-Navarro, M. C., Hao, Y. H., Kilgore, J. A., Perez-Castro, L., Braverman, J., Borenstein-Auerbach, N., Kim, M., Lesner, N. P., Mishra, P., Brabletz, T., Shay, J. W., DeBerardinis, R. J., Williams, N. S., Yilmaz, O. H. & Conacci-Sorrell, M., Sep 1 2019, In : Genes & development. 33, 17-18, p. 1236-1251 16 p.

Research output: Contribution to journalArticle

Open Access
Kynurenine
Tryptophan
Colonic Neoplasms
Arylformamidase
Large Neutral Amino Acid-Transporter 1
1 Citation (Scopus)

NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers

Motea, E. A., Huang, X., Singh, N., Kilgore, J. A., Williams, N. S., Xie, X-J., Gerber, D. E., Beg, M. S., Bey, E. A. & Boothman, D. A., Apr 15 2019, In : Clinical Cancer Research. 25, 8, p. 2601-2609 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
NAD
Neoplasms
Pharmacokinetics
Adenosine Triphosphate

Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells

Wang, X. D., Hu, R., Ding, Q., Savage, T. K., Huffman, K. E., Williams, N. S., Cobb, M. H., Minna, J. D., Johnson, J. E. & Yu, Y., Dec 1 2019, In : Nature communications. 10, 1, 3201.

Research output: Contribution to journalArticle

Open Access
Neuroendocrine Cells
Neuroendocrine Tumors
Small Cell Lung Carcinoma
Tumors
Lung Neoplasms
2018
3 Citations (Scopus)

Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells

Qi, C., Wang, X., Shen, Z., Chen, S., Yu, H., Williams, N. S. & Wang, G., May 1 2018, In : Cell Research. 28, 5, p. 544-555 12 p.

Research output: Contribution to journalArticle

Open Access
Receptors, Tumor Necrosis Factor, Member 25
Apoptosis
Antimitotic Agents
Neoplasms
Tumor Necrosis Factor Ligand Superfamily Member 15
13 Citations (Scopus)

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

McMillan, E. A., Ryu, M. J., Diep, C. H., Mendiratta, S., Clemenceau, J. R., Vaden, R. M., Kim, J. H., Motoyaji, T., Covington, K. R., Peyton, M., Huffman, K., Wu, X., Girard, L., Sung, Y., Chen, P. H., Mallipeddi, P. L., Lee, J. Y., Hanson, J., Voruganti, S., Yu, Y. & 20 others, Park, S., Sudderth, J., DeSevo, C., Muzny, D. M., Doddapaneni, H. V., Gazdar, A., Gibbs, R. A., Hwang, T. H., Heymach, J. V., Wistuba, I., Coombes, K. R., Williams, N. S., Wheeler, D. A., MacMillan, J. B., Deberardinis, R. J., Roth, M. G., Posner, B. A., Minna, J. D., Kim, H. S. & White, M. A., May 3 2018, In : Cell. 173, 4, p. 864-878.e29

Research output: Contribution to journalArticle

Lung Neoplasms
Neoplasms
Oncology
Biosynthesis
Small Molecule Libraries
1 Citation (Scopus)

Discovery of Cytochrome P450 4F11-Activated Inhibitors of Stearoyl Coenzyme A Desaturase

Winterton, S. E., Capota, E., Wang, X., Chen, H., Mallipeddi, P. L., Williams, N. S., Posner, B. A., Nijhawan, D. & Ready, J. M., Jan 12 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Cytochrome P-450 Enzyme System
Unsaturated Fatty Acids
Structure-Activity Relationship
Urea
1 Citation (Scopus)

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9

Zhang, L. S., Kang, X., Lu, J., Zhang, Y., Wu, X., Wu, G., Zheng, J., Tuladhar, R., Shi, H., Wang, Q., Morlock, L., Yao, H., Huang, J-S., Maire, P., Kim, J., Williams, N. S., Xu, J., Chen, C., Zhang, C. & Lum, L., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Catenins
Acute Myeloid Leukemia
Neoplasms
Proteins
Genetic Translocation
3 Citations (Scopus)

Neuroprotective efficacy of P7C3 compounds in primate hippocampus

Bauman, M. D., Schumann, C. M., Carlson, E. L., Taylor, S. L., Vázquez-Rosa, E., Cintrón-Pérez, C. J., Shin, M. K., Williams, N. S. & Pieper, A. A., Dec 1 2018, In : Translational Psychiatry. 8, 1, 202.

Research output: Contribution to journalArticle

Bromodeoxyuridine
Primates
Hippocampus
Neurogenesis
Neurons
18 Citations (Scopus)

Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells

Nanayakkara, A. K., Follit, C. A., Chen, G., Williams, N. S., Vogel, P. D. & Wise, J. G., Dec 1 2018, In : Scientific Reports. 8, 1, 967.

Research output: Contribution to journalArticle

P-Glycoprotein
Multiple Drug Resistance
Mortality
Neoplasms
Prostatic Neoplasms

Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses

Lewis, J. E., Singh, N., Holmila, R. J., Sumer, B. D., Williams, N. S., Furdui, C. M., Kemp, M. L. & Boothman, D. A., Jan 1 2018, (Accepted/In press) In : Seminars in Radiation Oncology.

Research output: Contribution to journalArticle

NAD
Radiotherapy
Radiation Tolerance
Metabolic Networks and Pathways
Ionizing Radiation
2017
12 Citations (Scopus)

(-)-P7C3-S243 Protects a Rat Model of Alzheimer's Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia

Voorhees, J. R., Remy, M. T., Cintrón-Pérez, C. J., El Rassi, E., Khan, M. Z., Dutca, L. M., Yin, T. C., McDaniel, L. N., Williams, N. S., Brat, D. J. & Pieper, A. A., Jan 1 2017, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

Amyloid
Neuroglia
Alzheimer Disease
Depression
Carbazoles
70 Citations (Scopus)

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15

Han, T., Goralski, M., Gaskill, N., Capota, E., Kim, J., Ting, T. C., Xie, Y., Williams, N. S. & Nijhawan, D., Mar 16 2017, (Accepted/In press) In : Science. p. 1-21 21 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Sulfonamides
Proteolysis
RNA Precursors
N-((5-bromo-2-thienyl)sulfonyl)-2,4-dichlorobenzamide
9 Citations (Scopus)

Biomarker accessible and chemically addressable mechanistic subtypes of braf melanoma

Eskiocak, B., McMillan, E. A., Mendiratta, S., Kollipara, R. K., Zhang, H., Humphries, C. G., Wang, C., Garcia-Rodriguez, J., Ding, M., Zaman, A., Rosales, T. I., Eskiocak, U., Smith, M. P., Sudderth, J., Komurov, K., Deberardinis, R. J., Wellbrock, C., Davies, M. A., Wargo, J. A., Yu, Y. & 7 others, De Brabander, J. K., Williams, N. S., Chin, L., Rizos, H., Long, G. V., Kittler, R. & White, M. A., 2017, In : Cancer Discovery. 7, 8, p. 832-851 20 p.

Research output: Contribution to journalArticle

Melanoma
Biomarkers
Mitogen-Activated Protein Kinase Kinases
Neoplasms
MAP Kinase Signaling System
17 Citations (Scopus)

Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist

Moon, J., Zhou, H., Zhang, L. S., Tan, W., Liu, Y., Zhang, S., Morlock, L. K., Bao, X., Palecek, S. P., Feng, J. Q., Williams, N. S., Amatruda, J. F., Olson, E. N., Bassel-Duby, R. & Lum, L., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1649-1654 6 p.

Research output: Contribution to journalArticle

Porcupines
Non-Fibrillar Collagens
Regeneration
Wnt Proteins
Acyltransferases
12 Citations (Scopus)

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors

Tso, S. C., Lou, M., Wu, C. Y., Gui, W. J., Chuang, J. L., Morlock, L. K., Williams, N. S., Wynn, R. M., Qi, X. & Chuang, D. T., Feb 9 2017, In : Journal of Medicinal Chemistry. 60, 3, p. 1142-1150 9 p.

Research output: Contribution to journalArticle

Pyruvate Dehydrogenase Complex
Liver
Obesity
Adenosine Triphosphate
Glucose
6 Citations (Scopus)

Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair

Antczak, M. I., Zhang, Y., Wang, C., Doran, J., Naidoo, J., Voruganti, S., Williams, N. S., Markowitz, S. D. & Ready, J. M., May 11 2017, In : Journal of Medicinal Chemistry. 60, 9, p. 3979-4001 23 p.

Research output: Contribution to journalArticle

Prostaglandin Antagonists
Dinoprostone
Prostaglandins
Oxidoreductases
Regeneration
38 Citations (Scopus)

Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study

McCarthy, J. S., Lotharius, J., Rückle, T., Chalon, S., Phillips, M. A., Elliott, S., Sekuloski, S., Griffin, P., Ng, C. L., Fidock, D. A., Marquart, L., Williams, N. S., Gobeau, N., Bebrevska, L., Rosario, M., Marsh, K. & Möhrle, J. J., Jun 1 2017, In : The Lancet Infectious Diseases. 17, 6, p. 626-635 10 p.

Research output: Contribution to journalArticle

Antimalarials
Pharmacokinetics
Safety
Mefloquine
Half-Life
20 Citations (Scopus)

Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing ebola virus immune evasion

Luthra, P., Aguirre, S., Yen, B. C., Pietzsch, C. A., Sanchez-Aparicio, M. T., Tigabu, B., Morlock, L. K., García-Sastre, A., Leung, D. W., Williams, N. S., Fernandez-Sesma, A., Bukreyev, A. & Basler, C. F., Mar 1 2017, In : mBio. 8, 2, e00368-17.

Research output: Contribution to journalArticle

Ebolavirus
Topoisomerase II Inhibitors
Immune Evasion
Interferons
DNA Damage
2016
7 Citations (Scopus)

Development of a triazole class of highly potent Porcn inhibitors

You, L., Zhang, C., Yarravarapu, N., Morlock, L., Wang, X., Zhang, L., Williams, N. S., Lum, L. & Chen, C., Dec 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 24, p. 5891-5895 5 p.

Research output: Contribution to journalArticle

Porcupines
Triazoles
Scaffolds
Wnt Proteins
Acyltransferases
20 Citations (Scopus)

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

Theodoropoulos, P. C., Gonzales, S. S., Winterton, S. E., Rodriguez-Navas, C., McKnight, J. S., Morlock, L. K., Hanson, J. M., Cross, B., Owen, A. E., Duan, Y., Moreno, J. R., Lemoff, A., Mirzaei, H., Posner, B. A., Williams, N. S., Ready, J. M. & Nijhawan, D., Apr 1 2016, In : Nature Chemical Biology. 12, 4, p. 218-225 8 p.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Benzothiazoles
Neoplasms
Cell Line
Cytochrome P-450 Enzyme System
25 Citations (Scopus)

Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors

Huang, X., Motea, E. A., Moore, Z. R., Yao, J., Dong, Y., Chakrabarti, G., Kilgore, J. A., Silvers, M. A., Patidar, P. L., Cholka, A., Fattah, F., Cha, Y., Anderson, G. G., Kusko, R., Peyton, M., Yan, J., Xie, X. J., Sarode, V., Williams, N. S., Minna, J. D. & 4 others, Beg, M., Gerber, D. E., Bey, E. A. & Boothman, D. A., Dec 12 2016, In : Cancer Cell. 30, 6, p. 940-952 13 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Neoplasms
Poly(ADP-ribose) Polymerases
Recycling
Caspases
1 Citation (Scopus)

NQO1 bioactivatable drugs enhance radiation responses

Bey, E. A., Meade, J. C., Silvers, M. A., Motea, E. A., Patidar, P. L., Brekken, R., Deja, S., Merritt, M. E., Kilgore, J. A., Liu, Y., Huang, X., Li, L., Yordy, J., Williams, N. S., Gao, J. & Boothman, D. A., Jan 1 2016, Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment. Springer International Publishing, p. 225-252 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Radiation
Pharmaceutical Preparations
Neoplasms
Catalase
NAD
25 Citations (Scopus)

Posaconazole, a second-generation triazole antifungal drug, inhibits the hedgehog signaling pathway and progression of basal cell carcinoma

Chen, B., Trang, V., Lee, A., Williams, N. S., Wilson, A. N., Epstein, E. H., Tang, J. Y. & Kim, J., May 1 2016, In : Molecular Cancer Therapeutics. 15, 5, p. 866-876 11 p.

Research output: Contribution to journalArticle

Triazoles
Itraconazole
Basal Cell Carcinoma
Drug Interactions
Pharmaceutical Preparations
15 Citations (Scopus)

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

Zhang, L., Theodoropoulos, P. C., Eskiocak, U., Wang, W., Moon, Y. A., Posner, B., Williams, N. S., Wright, W. E., Kim, S. B., Nijhawan, D., De Brabander, J. K. & Shay, J. W., Oct 19 2016, In : Science Translational Medicine. 8, 361, 361ra140.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Colorectal Neoplasms
Adenomatous Polyposis Coli Protein
Epithelial Cells
APC Genes
2015
15 Citations (Scopus)

Diet-induced unresolved ER stress hinders KRAS-driven lung tumorigenesis

Ramadori, G., Konstantinidou, G., Venkateswaran, N., Biscotti, T., Morlock, L., Galié, M., Williams, N. S., Luchetti, M., Santinelli, A., Scaglioni, P. P. & Coppari, R., Jan 6 2015, In : Cell Metabolism. 21, 1, p. 117-125 9 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Carcinogenesis
Diet
Lung
Neoplasms

Erratum: The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation (Chemistry and Biology (2014) 21 (1680-689))

Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Apr 23 2015, In : Chemistry and Biology. 22, 4, p. 559 1 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy

Ma, X., Huang, X., Moore, Z., Huang, G., Kilgore, J. A., Wang, Y., Hammer, S., Williams, N. S., Boothman, D. A. & Gao, J., Feb 28 2015, In : Journal of Controlled Release. 200, p. 201-211 11 p.

Research output: Contribution to journalArticle

Prodrugs
Micelles
Esterases
Lung Neoplasms
Ethylene Glycol
11 Citations (Scopus)

High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma

Wolff, N. C., Pavía-Jiménez, A., Tcheuyap, V. T., Alexander, S., Vishwanath, M., Christie, A., Xie, X. J., Williams, N. S., Kapur, P., Posner, B., McKay, R. M. & Brugarolas, J., 2015, In : Oncotarget. 6, 19, p. 16951-16962 12 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Lethal Genes
Synthetic Genes
Kidney Neoplasms
6 Citations (Scopus)

Identification of CREB3L1 as a biomarker predicting doxorubicin treatment outcome

Denard, B., Pavia-Jimenez, A., Chen, W., Williams, N. S., Naina, H., Collins, R., Brugarolas, J. & Ye, J., Jun 25 2015, In : PLoS One. 10, 6, e0129233.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
doxorubicin
response elements
Biomarkers
Doxorubicin
85 Citations (Scopus)

Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

Zhang, Y., Desai, A., Yang, S. Y., Bae, K. B., Antczak, M. I., Fink, S. P., Tiwari, S., Willis, J. E., Williams, N. S., Dawson, D. M., Wald, D., Chen, W. D., Wang, Z., Kasturi, L., Larusch, G. A., He, L., Cominelli, F., Di Martino, L., Djuric, Z., Milne, G. L. & 12 others, Chance, M., Sanabria, J., Dealwis, C., Mikkola, D., Naidoo, J., Wei, S., Tai, H. H., Gerson, S. L., Ready, J. M., Posner, B., Willson, J. K. V. & Markowitz, S. D., Jun 12 2015, In : Science. 348, 6240, 2340.

Research output: Contribution to journalArticle

15-hydroxyprostaglandin dehydrogenase
Prostaglandins
Regeneration
Enzymes
Dinoprostone
29 Citations (Scopus)

Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury

Kemp, S. W. P., Szynkaruk, M., Stanoulis, K. N., Wood, M. D., Liu, E. H., Willand, M. P., Morlock, L., Naidoo, J., Williams, N. S., Ready, J. M., Mangano, T. J., Beggs, S., Salter, M. W., Gordon, T., Pieper, A. A. & Borschel, G. H., Jan 2 2015, In : Neuroscience. 284, p. 202-216 15 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Neuroprotective Agents
Nerve Crush
Peripheral Nerve Injuries
Hypesthesia
19 Citations (Scopus)

Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease

De Jesús-Cortés, H., Miller, A. D., Britt, J. K., DeMarco, A. J., De Jesús-Cortés, M., Stuebing, E., Naidoo, J., Vázquez-Rosa, E., Morlock, L., Williams, N. S., Ready, J. M., Narayanan, N. S. & Pieper, A. A., 2015, In : Parkinson's Disease. 1, 15010.

Research output: Contribution to journalReview article

Oxidopamine
Parkinson Disease
Dopaminergic Neurons
Cell Death
Medial Forebrain Bundle
69 Citations (Scopus)

The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis

Walker, A. K., Rivera, P. D., Wang, Q., Chuang, J. C., Tran, S., Osborne-Lawrence, S., Estill, S. J., Starwalt, R., Huntington, P., Morlock, L., Naidoo, J., Williams, N. S., Ready, J. M., Eisch, A. J., Pieper, A. A. & Zigman, J. M., Apr 2 2015, In : Molecular Psychiatry. 20, 4, p. 500-508 9 p.

Research output: Contribution to journalArticle

Neurogenesis
Antidepressive Agents
Caloric Restriction
Dentate Gyrus
Depression
2014
16 Citations (Scopus)

Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase

Tso, S. C., Gui, W. J., Wu, C. Y., Chuang, J. L., Qi, X., Skvorak, K. J., Dorko, K., Wallace, A. L., Morlock, L. K., Lee, B. H., Hutson, S. M., Strom, S. C., Williams, N. S., Tambar, U. K., Wynn, R. M. & Chuang, D. T., Jul 25 2014, In : Journal of Biological Chemistry. 289, 30, p. 20583-20593 11 p.

Research output: Contribution to journalArticle

3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Phosphotransferases
Derivatives
Branched Chain Amino Acids
Maple Syrup Urine Disease
35 Citations (Scopus)

Discovery of a neuroprotective chemical, (S)- N -(3-(3,6-Dibromo-9 H -carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties

Naidoo, J., De Jesus-Cortes, H., Huntington, P., Estill, S., Morlock, L. K., Starwalt, R., Mangano, T. J., Williams, N. S., Pieper, A. A. & Ready, J. M., May 8 2014, In : Journal of Medicinal Chemistry. 57, 9, p. 3746-3754 9 p.

Research output: Contribution to journalArticle

Amines
Neurons
Neurogenesis
Neuroprotective Agents
Substantia Nigra
31 Citations (Scopus)

Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243

Dutca, L. M., Stasheff, S. F., Hedberg-Buenz, A., Rudd, D. S., Batra, N., Blodi, F. R., Yorek, M. S., Yin, T., Shankar, M., Herlein, J. A., Naidoo, J., Morlock, L., Williams, N., Kardon, R. H., Anderson, M. G., Pieper, A. A. & Harper, M. M., Dec 2 2014, In : Investigative Ophthalmology and Visual Science. 55, 12, p. 8330-8341 12 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Cell Physiological Phenomena
Wounds and Injuries
Neuroprotective Agents
Pathologic Processes
11 Citations (Scopus)

Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors

Chau, V., Lim, S. K., Mo, W., Liu, C., Patel, A. J., McKay, R. M., Wei, S., Posner, B. A., De Brabander, J. K., Williams, N. S., Parada, L. F. & Le, L. Q., Jan 15 2014, In : Cancer Research. 74, 2, p. 586-597 12 p.

Research output: Contribution to journalArticle

Neurilemmoma
Apoptosis
Therapeutics
Growth
Plexiform Neurofibroma
50 Citations (Scopus)

QseC inhibitors as an antivirulence approach for gram-negative pathogens

Curtis, M. M., Russell, R., Moreira, C. G., Adebesin, A. M., Wang, C., Williams, N. S., Taussig, R., Stewart, D., Zimmern, P. E., Lu, B., Prasad, R. N., Zhu, C., Rasko, D. A., Huntley, J. F., Falck, J. R. & Sperandio, V., Oct 17 2014, In : mBio. 5, 6, e02165-14.

Research output: Contribution to journalArticle

Virulence
Information Science
Microbiota
Prodrugs
Structure-Activity Relationship
49 Citations (Scopus)

Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection

Derebe, M. G., Zlatkov, C. M., Gattu, S., Ruhn, K. A., Vaishnava, S., Diehl, G. E., MacMillan, J. B., Williams, N. S. & Hooper, L. V., 2014, In : eLife. 3, p. e03206

Research output: Contribution to journalArticle

Serum Amyloid A Protein
Retinol-Binding Proteins
Protein Transport
Vitamin A
Bacterial Infections
45 Citations (Scopus)

Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket

Tso, S. C., Qi, X., Gui, W. J., Wu, C. Y., Chuang, J. L., Wernstedt-Asterholm, I., Morlock, L. K., Owens, K. R., Scherer, P. E., Williams, N. S., Tambar, U. K., Wynn, R. M. & Chuang, D. T., Feb 14 2014, In : Journal of Biological Chemistry. 289, 7, p. 4432-4443 12 p.

Research output: Contribution to journalArticle

Medical problems
Obesity
Adenosine Triphosphate
Glucose
Obese Mice
12 Citations (Scopus)

The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation

Fan, C. W., Chen, B., Franco, I., Lu, J., Shi, H., Wei, S., Wang, C., Wu, X., Tang, W., Roth, M. G., Williams, N. S., Hirsch, E., Chen, C. & Lum, L., Dec 18 2014, In : Chemistry and Biology. 21, 12, p. 1680-1689 10 p.

Research output: Contribution to journalArticle

Cilia
Phosphatidylinositol-4-Phosphate 3-Kinase
Hedgehog Proteins
Chemical activation
Cell membranes
2013
28 Citations (Scopus)
Ultrafiltration
Protein Binding
Blood Proteins
Recovery
Dialysis
59 Citations (Scopus)

Comparative benefits of nab-paclitaxel over gemcitabine or polysorbate-based docetaxel in experimental pancreatic cancer

Awasthi, N., Zhang, C., Schwarz, A. M., Hinz, S., Wang, C., Williams, N. S., Schwarz, M. A. & Schwarz, R. E., Oct 2013, In : Carcinogenesis. 34, 10, p. 2361-2369 9 p.

Research output: Contribution to journalArticle

docetaxel
gemcitabine
Polysorbates
Pancreatic Neoplasms
Inhibitory Concentration 50
25 Citations (Scopus)

Identification of DNMT1 selective antagonists using a novel scintillation proximity assay

Kilgore, J. A., Du, X., Melito, L., Wei, S., Wang, C., Chin, H. G., Posner, B., Pradhan, S., Ready, J. M. & Williams, N. S., Jul 5 2013, In : Journal of Biological Chemistry. 288, 27, p. 19673-19684 12 p.

Research output: Contribution to journalArticle

Methyltransferases
Scintillation
Assays
Catalase
DNA
60 Citations (Scopus)

Small-molecule activation of the TRAIL receptor DR5 in human cancer cells

Wang, G., Wang, X., Yu, H., Wei, S., Williams, N., Holmes, D. L., Halfmann, R., Naidoo, J., Wang, L., Li, L., Chen, S., Harran, P., Lei, X. & Wang, X., Feb 2013, In : Nature Chemical Biology. 9, 2, p. 84-89 6 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand Receptors
TNF-Related Apoptosis-Inducing Ligand
Apoptosis
Neoplasms
Tumor Necrosis Factor-alpha
27 Citations (Scopus)

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase

Tso, S. C., Qi, X., Gui, W. J., Chuang, J. L., Morlock, L. K., Wallace, A. L., Ahmed, K., Laxman, S., Campeau, P. M., Lee, B. H., Hutson, S. M., Tu, B. P., Williams, N. S., Tambar, U. K., Wynn, R. M. & Chuang, D. T., Jun 11 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 24, p. 9728-9733 6 p.

Research output: Contribution to journalArticle

3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Branched Chain Amino Acids
Phosphotransferases
Heart Failure
Maple Syrup Urine Disease
40 Citations (Scopus)

The development of highly potent inhibitors for porcupine

Wang, X., Moon, J., Dodge, M. E., Pan, X., Zhang, L., Hanson, J. M., Tuladhar, R., Ma, Z., Shi, H., Williams, N. S., Amatruda, J. F., Carroll, T. J., Lum, L. & Chen, C., Mar 28 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2700-2704 5 p.

Research output: Contribution to journalArticle

Porcupines
Wnt Proteins
Lipoylation
Kidney Tubules
Zebrafish
93 Citations (Scopus)

XSystematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer

Kim, H. S., Mendiratta, S., Kim, J., Pecot, C. V., Larsen, J. E., Zubovych, I., Seo, B. Y., Kim, J., Eskiocak, B., Chung, H., McMillan, E., Wu, S., De Brabander, J., Komurov, K., Toombs, J. E., Wei, S., Peyton, M., Williams, N., Gazdar, A. F., Posner, B. A. & 6 others, Brekken, R. A., Sood, A. K., Deberardinis, R. J., Roth, M. G., Minna, J. D. & White, M. A., Oct 24 2013, In : Cell. 155, 3

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Tumors
Cells
Coat Protein Complex I
Cytology