• 2434 Citations
  • 30 h-Index
1982 …2019
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Fingerprint Dive into the research topics where Richard M Wynn is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 5 Similar Profiles
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) Medicine & Life Sciences
Maple Syrup Urine Disease Medicine & Life Sciences
Branched Chain Amino Acids Medicine & Life Sciences
Carboxy-Lyases Medicine & Life Sciences
Pyruvate Dehydrogenase Complex Medicine & Life Sciences
Chaperonins Chemical Compounds
Thiamine Pyrophosphate Medicine & Life Sciences
Carrier Proteins Medicine & Life Sciences

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Research Output 1982 2019

  • 2434 Citations
  • 30 h-Index
  • 87 Article
  • 1 Chapter

In vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma

Suh, E. H., Hackett, E. P., Wynn, R. M., Chuang, D. T., Zhang, B., Luo, W., Sherry, D. & Park, J. M., Dec 1 2019, In : Scientific Reports. 9, 1, 340.

Research output: Contribution to journalArticle

Branched Chain Amino Acids
Glioblastoma
Leucine
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Glioma
2 Citations (Scopus)

Targeting BCAA catabolism to treat obesity-associated insulin resistance

Zhou, M., Shao, J., Wu, C. Y., Shu, L., Dong, W., Liu, Y., Chen, M., Wynn, R. M., Wang, J., Wang, J., Gui, W. J., Qi, X., Lusis, A. J., Li, Z., Wang, W., Ning, G., Yang, X., Chuang, D. T., Wang, Y. & Sun, H., Sep 1 2019, In : Diabetes. 68, 9, p. 1730-1746 17 p.

Research output: Contribution to journalArticle

Open Access
Branched Chain Amino Acids
Insulin Resistance
Obesity
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Keto Acids

Therapeutic Effect of Targeting Branched-Chain Amino Acid Catabolic Flux in Pressure-Overload Induced Heart Failure

Chen, M., Gao, C., Yu, J., Ren, S., Wang, M., Wynn, R. M., Chuang, D. T., Wang, Y. & Sun, H., Jun 4 2019, In : Journal of the American Heart Association. 8, 11, e011625.

Research output: Contribution to journalArticle

Open Access
Branched Chain Amino Acids
Therapeutic Uses
Heart Failure
Pressure
Heart Ventricles
2 Citations (Scopus)

A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity

Wu, C. Y., Satapati, S., Gui, W., Max Wynn, R., Sharma, G., Lou, M., Qi, X., Burgess, S. C., Malloy, C., Khemtong, C., Dean Sherry, A., Chuang, D. T. & Merritt, M. E., Jan 1 2018, In : Journal of Biological Chemistry. 293, 25, p. 9604-9613 10 p.

Research output: Contribution to journalArticle

Pyruvate Dehydrogenase Complex
Obese Mice
Protein-Serine-Threonine Kinases
Protein Kinase Inhibitors
Pyruvic Acid
7 Citations (Scopus)

Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice

Wu, C. Y., Tso, S. C., Chuang, J. L., Gui, W. J., Lou, M., Sharma, G., Khemtong, C., Qi, X., Wynn, R. M. & Chuang, D. T., Jan 1 2018, (Accepted/In press) In : Molecular Metabolism.

Research output: Contribution to journalArticle

Obese Mice
Lipogenesis
Carrier Proteins
Knockout Mice
Carbohydrates