• 46086 Citations
  • 105 h-Index
1979 …2019

Research output per year

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Research Output

2019

A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling

Nagati, J. S., Xu, M., Garcia, T., Comerford, S. A., Hammer, R. E. & Garcia, J. A., Jan 1 2019, In : PloS one. 14, 11, e0225105.

Research output: Contribution to journalArticle

Open Access

MiR-26 suppresses adipocyte progenitor differentiation and fat production by targeting Fbxl19

Acharya, A., Berry, D. C., Zhang, H., Jiang, Y., Jones, B. T., Hammer, R. E., Graff, J. M. & Mendell, J. T., Oct 1 2019, In : Genes and Development. 33, 19-20, p. 1367-1380 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Modulation of mutant krasG12D-driven lung tumorigenesis in vivo by gain or loss of PCDH7 function

Zhou, X., Padanad, M. S., Evers, B. M., Smith, B., Novaresi, N., Suresh, S., Richardson, J. A., Stein, E., Zhu, J., Hammer, R. E. & O'Donnell, K. A., Feb 1 2019, In : Molecular Cancer Research. 17, 2, p. 594-603 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice

Linden, A. G., Li, S., Choi, H. Y., Fang, F., Fukasawa, M., Uyeda, K., Hammer, R. E., Horton, J. D., Engelking, L. & Liang, G., Jan 1 2018, In : Journal of Lipid Research. 59, 3, p. 475-487 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Loss of Dis3l2 partially phenocopies perlman syndrome in mice and results in upregulation of Igf2 in nephron progenitor cells

Hunter, R. W., Liu, Y., Manjunath, H., Acharya, A., Jones, B. T., Zhang, H., Chen, B., Ramalingam, H., Hammer, R. E., Xie, Y., Richardson, J. A., Rakheja, D., Carroll, T. J. & Mendell, J. T., Jul 1 2018, In : Genes and Development. 32, 13-14, p. 903-908 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice

Rong, S., Cortés, V. A., Rashid, S., Anderson, N. N., McDonald, J. G., Liang, G., Moon, Y. A., Hammer, R. E. & Horton, J. D., Feb 28 2017, In : eLife. 6, e25015.

Research output: Contribution to journalArticle

36 Scopus citations

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis

Xian, X., Ding, Y., Dieckmann, M., Zhou, L., Plattner, F., Liu, M., Parks, J. S., Hammer, R. E., Boucher, P., Tsai, S. & Herz, J., Nov 16 2017, In : eLife. 6, e29292.

Research output: Contribution to journalArticle

15 Scopus citations

Modeling renal cell carcinoma in mice: Bap1 and Pbrm1 inactivation drive tumor grade

Gu, Y. F., Cohn, S., Christie, A., McKenzie, T., Wolff, N., Do, Q. N., Madhuranthakam, A. J., Pedrosa, I., Wang, T., Dey, A., Busslinger, M., Xie, X-J., Hammer, R. E., McKay, R. M., Kapur, P. & Brugarolas, J. B., 2017, In : Cancer Discovery. 7, 8, p. 900-917 18 p.

Research output: Contribution to journalArticle

34 Scopus citations

The human leukocyte antigen (HLA)-B27 peptidome in vivo, in spondyloarthritis-susceptible HLA-B27 transgenic rats and the effect of Erap1 deletion

Barnea, E., Kadosh, D. M., Haimovich, Y., Satumtira, N., Dorris, M. L., Nguyen, M. T., Hammer, R. E., Tran, T. M., Colbert, R. A., Taurog, J. D. & Admon, A., Apr 1 2017, In : Molecular and Cellular Proteomics. 16, 4, p. 642-662 21 p.

Research output: Contribution to journalArticle

24 Scopus citations

The interplay of ethics, animal welfare, and IACUC oversight on the reproducibility of animal studies

Pritt, S. L. & Hammer, R. E., Apr 1 2017, In : Comparative Medicine. 67, 2, p. 101-105 5 p.

Research output: Contribution to journalReview article

6 Scopus citations
2016

Mesolimbic neuropeptide W coordinates stress responses under novel environments

Motoike, T., Long, J. M., Tanaka, H., Sinton, C. M., Skach, A., Williams, S. C., Hammer, R. E., Sakurai, T. & Yanagisawa, M., May 24 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. 6023-6028 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

p53 genes function to restrain mobile elements

Wylie, A., Jones, A. E., D’Brot, A., Lu, W. J., Kurtz, P., Moran, J. V., Rakheja, D., Chen, K., Hammer, R. E., Comerford, S. A., Amatruda, J. F. & Abrams, J. M., Jan 1 2016, In : Genes and Development. 30, 1, p. 64-77 14 p.

Research output: Contribution to journalArticle

70 Scopus citations
2015

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance

Moon, Y. A., Ochoa, C. R., Mitsche, M. A., Hammer, R. E. & Horton, J. D., Jan 1 2015, In : Journal of lipid research. 55, 12, p. 2597-2605 9 p., A16.

Research output: Contribution to journalArticle

35 Scopus citations

Lrp4 domains differentially regulate limb/brain development and synaptic plasticity

Pohlkamp, T., Durakoglugil, M. S., Lane-Donovan, C., Xian, X., Johnson, E. B., Hammer, R. E. & Herz, J., Feb 17 2015, In : PloS one. 10, 2, e0116701.

Research output: Contribution to journalArticle

10 Scopus citations

Reelin protects against amyloid β toxicity in vivo

Lane-Donovan, C., Philips, G. T., Wasser, C. R., Durakoglugil, M. S., Masiulis, I., Upadhaya, A., Pohlkamp, T., Coskun, C., Kotti, T., Steller, L., Hammer, R. E., Frotscher, M., Bock, H. H. & Herz, J., Jul 7 2015, In : Science Signaling. 8, 384, ra67.

Research output: Contribution to journalArticle

47 Scopus citations
2014

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., Horton, J. D., Hammer, R. E., McKnight, S. L. & Tu, B. P., Dec 18 2014, In : Cell. 159, 7, p. 1591-1602 12 p.

Research output: Contribution to journalArticle

245 Scopus citations

An acetate switch regulates stress erythropoiesis

Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H., Moon, Y. A., Gerard, R. D., Huang, C-L., Comerford, S. A., Hammer, R. E., Horton, J. D., Chen, R. & Garcia, J. A., Sep 1 2014, In : Nature medicine. 20, 9, p. 1018-1026 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis

Wang, S. S., Gu, Y. F., Wolff, N., Stefanius, K., Christie, A., Dey, A., Hammer, R. E., Xie, X-J., Rakheja, D., Pedrosa, I., Carroll, T. J., McKay, R. M., Kapur, P. & Brugarolas, J. B., Nov 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 46, p. 16538-16543 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning

Wasser, C. R., Masiulis, I., Durakoglugil, M. S., Lane-Donovan, C., Xian, X., Beffert, U., Agarwala, A., Hammer, R. E. & Herz, J., Nov 25 2014, In : Science Signaling. 7, 353, ra113.

Research output: Contribution to journalArticle

21 Scopus citations

Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models

Nguyen, L. H., Robinton, D. A., Seligson, M. T., Wu, L., Li, L., Rakheja, D., Comerford, S. A., Ramezani, S., Sun, X., Parikh, M. S., Yang, E. H., Powers, J. T., Shinoda, G., Shah, S. P., Hammer, R. E., Daley, G. Q. & Zhu, H., Aug 11 2014, In : Cancer Cell. 26, 2, p. 248-261 14 p.

Research output: Contribution to journalArticle

95 Scopus citations

Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: Interplay with cerebral blood flow

Li, H., Guo, Q., Inoue, T., Polito, V. A., Tabuchi, K., Hammer, R. E., Pautler, R. G., Taffet, G. E. & Zheng, H., Aug 9 2014, In : Molecular Neurodegeneration. 9, 1, 28.

Research output: Contribution to journalArticle

41 Scopus citations
2013

APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice

Choi, H. Y., Liu, Y., Tennert, C., Sugiura, Y., Karakatsani, A., Kröger, S., Johnson, E. B., Hammer, R. E., Lin, W. & Herz, J., Aug 20 2013, In : eLife. 2013, 2, e00220.

Research output: Contribution to journalArticle

30 Scopus citations

Pathogenesis of autosomal dominant hereditary spastic paraplegia (SPG6) revealed by a rat model.

Watanabe, F., Arnold, W. D., Hammer, R. E., Ghodsizadeh, O., Moti, H., Schumer, M., Hashmi, A., Hernandez, A., Sneh, A., Sahenk, Z. & Kisanuki, Y. Y., Nov 2013, In : Journal of neuropathology and experimental neurology. 72, 11, p. 1016-1028 13 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2012

Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats

Taurog, J. D., Rival, C., Van Duivenvoorde, L. M., Satumtira, N., Dorris, M. L., Sun, M., Shelton, J. M., Richardson, J. A., Hamra, F. K., Hammer, R. E. & Tung, K. S. K., Aug 1 2012, In : Arthritis and rheumatism. 64, 8, p. 2518-2528 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
6 Scopus citations

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

Owen, J. L., Zhang, Y., Bae, S. H., Farooqi, M. S., Liang, G., Hammer, R. E., Goldstein, J. L. & Brown, M. S., Oct 2 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 40, p. 16184-16189 6 p.

Research output: Contribution to journalArticle

134 Scopus citations
2011

The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells

Gao, Z., Ure, K., Ding, P., Nashaat, M., Yuan, L., Ma, J., Hammer, R. E. & Hsieh, J., Jun 29 2011, In : Journal of Neuroscience. 31, 26, p. 9772-9786 15 p.

Research output: Contribution to journalArticle

154 Scopus citations
2010

CDK5RAP2 regulates centriole engagement and cohesion in mice

Barrera, J. A., Kao, L. R., Hammer, R. E., Seemann, J., Fuchs, J. L. & Megraw, T. L., Mar 16 2010, In : Developmental cell. 18, 6, p. 913-926 14 p.

Research output: Contribution to journalArticle

92 Scopus citations

DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory

Li, Y., Hu, J., Höfer, K., Wong, A. M. S., Cooper, J. D., Birnbaum, S. G., Hammer, R. E. & Hofmann, S. L., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 13022-13031 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity

Alexander, M. S., Shi, X., Voelker, K. A., Grange, R. W., Garcia, J. A., Hammer, R. E. & Garry, D. J., Jan 15 2010, In : Developmental Biology. 337, 2, p. 396-404 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis

Li, H., Wang, Z., Wang, B., Guo, Q., Dolios, G., Tabuchi, K., Hammer, R. E., Südhof, T. C., Wang, R. & Zheng, H., Oct 1 2010, In : Journal of Biological Chemistry. 285, 40, p. 30598-30605 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Low blood pressure in endothelial cell-specific endothelin 1 knockout mice

Kisanuki, Y. Y., Emoto, N., Ohuchi, T., Widyantoro, B., Yagi, K., Nakayama, K., Kedzierski, R. M., Hammer, R. E., Yanagisawa, H., Williams, S. C., Richardson, J. A., Suzuki, T. & Yanagisawa, M., Jul 1 2010, In : Hypertension. 56, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

Li, H., Wang, B., Wang, Z., Guo, Q., Tabuchi, K., Hammer, R. E., Südhof, T. C. & Zheng, H., Oct 5 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 40, p. 17362-17367 6 p.

Research output: Contribution to journalArticle

88 Scopus citations
2009

Characterization of a Dazl-GFP germ cell-specific reporter

Nicholas, C. R., Xu, E. Y., Banani, S. F., Hammer, R. E., Hamra, F. K. & Reijo Pera, R. A., Jul 1 2009, In : Genesis. 47, 2, p. 74-84 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

Moon, Y. A., Hammer, R. E. & Horton, J. D., Apr 1 2009, In : Journal of lipid research. 50, 3, p. 412-423 12 p.

Research output: Contribution to journalArticle

106 Scopus citations

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

Wang, J., Alexander, P., Wu, L., Hammer, R. E., Cleaver, O. & McKnight, S. L., Jul 24 2009, In : Science. 325, 5939, p. 435-439 5 p.

Research output: Contribution to journalArticle

210 Scopus citations

Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2

Sakakibara, I., Fujino, T., Ishii, M., Tanaka, T., Shimosawa, T., Miura, S., Zhang, W., Tokutake, Y., Yamamoto, J., Awano, M., Iwasaki, S., Motoike, T., Okamura, M., Inagaki, T., Kita, K., Ezaki, O., Naito, M., Kuwaki, T., Chohnan, S., Yamamoto, T. T. & 4 others, Hammer, R. E., Kodama, T., Yanagisawa, M. & Sakai, J., Feb 4 2009, In : Cell Metabolism. 9, 2, p. 191-202 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

Cortés, V. A., Curtis, D. E., Sukumaran, S., Shao, X., Parameswara, V., Rashid, S., Smith, A. R., Ren, J., Esser, V., Hammer, R. E., Agarwal, A. K., Horton, J. D. & Garg, A., Feb 4 2009, In : Cell Metabolism. 9, 2, p. 165-176 12 p.

Research output: Contribution to journalArticle

147 Scopus citations

Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo

Ferdous, A., Caprioli, A., Iacovino, M., Martin, C. M., Morris, J., Richardson, J. A., Latif, S., Hammer, R. E., Harvey, R. P., Olson, E. N., Kyba, M. & Garry, D. J., Jan 20 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 3, p. 814-819 6 p.

Research output: Contribution to journalArticle

123 Scopus citations

Sterile testis complementation with spermatogonial lines restores fertility to DAZL-deficient rats and maximizes donor germline transmission

Richardson, T. E., Chapman, K. M., Dann, C. T., Hammer, R. E. & Hamra, F. K., Jul 21 2009, In : PloS one. 4, 7, e6308.

Research output: Contribution to journalArticle

23 Scopus citations
2008

Conformational switch of syntaxin-1 controls synaptic vesicle fusion

Gerber, S. H., Rah, J. C., Min, S. W., Liu, X., De Wit, H., Dulubova, I., Meyer, A. C., Rizo-Rey, J., Arancillo, M., Hammer, R. E., Verhage, M., Rosenmund, C. & Südhof, T. C., Sep 12 2008, In : Science. 321, 5895, p. 1507-1510 4 p.

Research output: Contribution to journalArticle

186 Scopus citations

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3

Chen, X., Tang, T. S., Tu, H., Nelson, O., Pook, M., Hammer, R. E., Nukina, N. & Bezprozvanny, I., Nov 26 2008, In : Journal of Neuroscience. 28, 48, p. 12713-12724 12 p.

Research output: Contribution to journalArticle

138 Scopus citations

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M. & Gordon, J. I., Oct 28 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 43, p. 16767-16772 6 p.

Research output: Contribution to journalArticle

796 Scopus citations

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis

Lee, Y. K., Schmidt, D. R., Cummins, C. L., Choi, M., Li, P., Zhang, Y., Goodwin, B., Hammer, R. E., Mangelsdorf, D. J. & Kliewer, S. A., Jun 1 2008, In : Molecular Endocrinology. 22, 6, p. 1345-1356 12 p.

Research output: Contribution to journalArticle

97 Scopus citations

PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen

Kotadia, S., Kao, L. R., Comerford, S. A., Jones, R. T., Hammer, R. E. & Megraw, T. L., Oct 23 2008, In : Oncogene. 27, 49, p. 6334-6346 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sohlh2 knockout mice are male-sterile because of degeneration of differentiating type a spermatogonia

Hao, J., Yamamoto, M., Richardson, T. E., Chapman, K. M., Denard, B. S., Hammer, R. E., Guang, Q. Z. & Hamra, F. K., Jun 1 2008, In : STEM CELLS. 26, 6, p. 1587-1597 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

White fat progenitor cells reside in the adipose vasculature

Tang, W., Zeve, D., Suh, J. M., Bosnakovski, D., Kyba, M., Hammer, R. E., Tallquist, M. D. & Graff, J. M., Oct 24 2008, In : Science. 322, 5901, p. 583-586 4 p.

Research output: Contribution to journalArticle

707 Scopus citations
2007

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice

Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M. & Südhof, T. C., Oct 5 2007, In : Science. 318, 5847, p. 71-76 6 p.

Research output: Contribution to journalArticle

604 Scopus citations

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., Elmquist, J. K., Gerard, R. D., Burgess, S. C., Hammer, R. E., Mangelsdorf, D. J. & Kliewer, S. A., Jun 6 2007, In : Cell Metabolism. 5, 6, p. 415-425 11 p.

Research output: Contribution to journalArticle

913 Scopus citations

Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells

Meeson, A. P., Shi, X., Alexander, M. S., Williams, R. S., Allen, R. E., Jiang, N., Adham, I. M., Goetsch, S. C., Hammer, R. E. & Garry, D. J., Apr 4 2007, In : EMBO Journal. 26, 7, p. 1902-1912 11 p.

Research output: Contribution to journalArticle

51 Scopus citations