• 11941 Citations
  • 56 h-Index
19982019
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Fingerprint Dive into the research topics where Rolf A Brekken is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 11 Similar Profiles
Vascular Endothelial Growth Factor A Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Pancreatic Neoplasms Medicine & Life Sciences
Tumors Chemical Compounds
Vascular Endothelial Growth Factor Receptor-2 Medicine & Life Sciences
Blood Vessels Medicine & Life Sciences
Growth Medicine & Life Sciences
Adenocarcinoma Medicine & Life Sciences

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Research Output 1998 2019

2-Amino-2,3-dihydro-1 H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy

Zhu, D., Huang, H., Pinkas, D. M., Luo, J., Ganguly, D., Fox, A. E., Arner, E., Xiang, Q., Tu, Z. C., Bullock, A. N., Brekken, R. A., Ding, K. & Lu, X., Jan 1 2019, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasms
Epithelial-Mesenchymal Transition
Inhibitory Concentration 50
Phosphotransferases

APR-246 alone and in combination with a phosphatidylserine-targeting antibody inhibits lung metastasis of human triple-negative breast cancer cells in nude mice

Liang, Y., Besch-Williford, C., Cook, M. T., Belenchia, A., Brekken, R. A. & Hyder, S. M., Jan 1 2019, In : Breast Cancer: Targets and Therapy. 11, p. 249-259 11 p.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Phosphatidylserines
Nude Mice
Neoplasm Metastasis
Lung

Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer

Cruz, V. H., Arner, E. N., Du, W., Bremauntz, A. E. & Brekken, R. A., Jan 1 2019, In : JCI Insight. 4, 9, e126117.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Phosphotransferases
Adenocarcinoma
Epithelial-Mesenchymal Transition
Pharmacology

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution

Hosein, A. N., Huang, H., Wang, Z., Parmar, K., Du, W., Huang, J., Maitra, A., Olson, E. N., Verma, U. & Brekken, R. A., Jul 23 2019, In : JCI Insight. 4, 16, e129212.

Research output: Contribution to journalArticle

Open Access
Adenocarcinoma
Fibroblasts
Neoplasms
Stromal Cells
Population
Cyclooxygenase 2
Pancreatic Neoplasms
Vascular Endothelial Growth Factor A
Adenocarcinoma
Therapeutics