• 3804 Citations
  • 32 h-Index
19972020

Research output per year

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Research Output

2020

Functional analysis of islet cells in vitro, in situ, and in vivo

Li, W. H., Jul 2020, In : Seminars in Cell and Developmental Biology. 103, p. 14-19 6 p.

Research output: Contribution to journalReview article

Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose

Bosma, K. J., Rahim, M., Singh, K., Goleva, S. B., Wall, M. L., Xia, J., Syring, K. E., Oeser, J. K., Poffenberger, G., McGuinness, O. P., Means, A. L., Powers, A. C., Li, W. H., Davis, L. K., Young, J. D. & O’Brien, R. M., 2020, In : Journal of molecular endocrinology. 64, 4, p. 235-248 14 p.

Research output: Contribution to journalArticle

2017

Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

Kim, J., Okamoto, H., Huang, Z. J., Anguiano, G., Chen, S., Liu, Q., Cavino, K., Xin, Y., Na, E., Hamid, R., Lee, J., Zambrowicz, B., Unger, R. H., Murphy, A. J., Xu, Y., Yancopoulos, G. D., Li, W-H. & Gromada, J., Jun 6 2017, In : Cell Metabolism. 25, 6, p. 1348-1361.e8

Research output: Contribution to journalArticle

51 Scopus citations

Probes for monitoring regulated exocytosis

Li, W. H., Jun 2017, In : Cell Calcium. 64, p. 65-71 7 p.

Research output: Contribution to journalReview article

2 Scopus citations

TargetLink, a new method for identifying the endogenous target set of a specific microRNA in intact living cells

Xu, Y., Chen, Y., Li, D., Liu, Q., Xuan, Z. & Li, W. H., Feb 1 2017, In : RNA Biology. 14, 2, p. 259-274 16 p.

Research output: Contribution to journalArticle

2016

Fluorescent sensors for imaging Zinc dynamics in biological fluids

Li, W. H., Apr 19 2016, Optical Probes in Biology. CRC Press, p. 291-315 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

MitoNEET-Parkin effects in pancreatic α- and β-cells, cellular survival, and intrainsular cross talk

Kusminski, C., Chen, S., Ye, R., Sun, K., Wang, Q. A., Spurgin, S. B., Sanders, P. E., Brozinick, J. T., Geldenhuys, W. J., Li, W-H., Unger, R. H. & Scherer, P. E., Jun 1 2016, In : Diabetes. 65, 6, p. 1534-1555 22 p.

Research output: Contribution to journalArticle

23 Scopus citations

Molecular genetic regulation of Slc30a8/ZnT8 reveals a positive association with glucose tolerance

Mitchell, R. K., Hu, M., Chabosseau, P. L., Cane, M. C., Meur, G., Bellomo, E. A., Carzaniga, R., Collinson, L. M., Li, W. H., Hodson, D. J. & Rutter, G. A., Jan 2016, In : Molecular Endocrinology. 30, 1, p. 77-91 15 p.

Research output: Contribution to journalArticle

35 Scopus citations

Tracking dynamic gap junctional coupling in live cells by local photoactivation and fluorescence imaging

Yang, S. & Li, W. H., 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1437. p. 181-191 11 p. (Methods in Molecular Biology; vol. 1437).

Research output: Chapter in Book/Report/Conference proceedingChapter

Zinc-sensitive MRI contrast agent detects differential release of Zn(II) ions from the healthy vs. malignant mouse prostate

Jordan, M. V. C., Lo, S. T., Chen, S., Preihs, C., Chirayil, S., Zhang, S., Kapur, P., Li, W. H., De Leon-Rodriguez, L. M., Lubag, A. J. M., Rofsky, N. M. & Sherry, A. D., Sep 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. E5464-E5471

Research output: Contribution to journalArticle

42 Scopus citations
2015

Genetic targeting of a small fluorescent zinc indicator to cell surface for monitoring zinc secretion

Li, D., Liu, L. & Li, W. H., Apr 17 2015, In : ACS chemical biology. 10, 4, p. 1054-1063 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

GLP-1 Receptor Mediated Targeting of a Fluorescent Zn2+ Sensor to Beta Cell Surface for Imaging Insulin/Zn2+ Release

Li, D., Huang, Z., Chen, S., Hu, Z. & Li, W. H., Aug 19 2015, In : Bioconjugate Chemistry. 26, 8, p. 1443-1450 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

ADCY5 couples glucose to insulin secretion in human islets

Hodson, D. J., Mitchell, R. K., Marselli, L., Pullen, T. J., Brias, S. G., Semplici, F., Everett, K. L., Cooper, D. M. F., Bugliani, M., Marchetti, P., Lavallard, V., Bosco, D., Piemonti, L., Johnson, P. R., Hughes, S. J., Li, D., Li, W. H., Shapiro, A. M. J. & Rutter, G. A., Sep 2014, In : Diabetes. 63, 9, p. 3009-3021 13 p.

Research output: Contribution to journalArticle

60 Scopus citations
2013

Fluorescent probes for monitoring regulated secretion

Li, W. H. & Li, D., Aug 2013, In : Current Opinion in Chemical Biology. 17, 4, p. 672-681 10 p.

Research output: Contribution to journalReview article

6 Scopus citations

Improved orange and red Ca2+ indicators and photophysical considerations for optogenetic applications

Wu, J., Liu, L., Matsuda, T., Zhao, Y., Rebane, A., Drobizhev, M., Chang, Y. F., Araki, S., Arai, Y., March, K., Hughes, T. E., Sagou, K., Miyata, T., Nagai, T., Li, W. H. & Campbell, R. E., Jun 19 2013, In : ACS Chemical Neuroscience. 4, 6, p. 963-972 10 p.

Research output: Contribution to journalArticle

112 Scopus citations

Lipotoxicity disrupts incretin-regulated human β cell connectivity

Hodson, D. J., Mitchell, R. K., Bellomo, E. A., Sun, G., Vinet, L., Meda, P., Li, D., Li, W. H., Bugliani, M., Marchetti, P., Bosco, D., Piemonti, L., Johnson, P., Hughes, S. J. & Rutter, G. A., Oct 1 2013, In : Journal of Clinical Investigation. 123, 10, p. 4182-4194 13 p.

Research output: Contribution to journalArticle

109 Scopus citations
2012

Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans

Schumacher, J. A., Hsieh, Y. W., Chen, S., Pirri, J. K., Alkema, M. J., Li, W. H., Chang, C. & Chuang, C. F., Nov 15 2012, In : Development (Cambridge). 139, 22, p. 4191-4201 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Photoactivatable fluorophores and techniques for biological imaging applications

Li, W. H. & Zheng, G., Mar 2012, In : Photochemical and Photobiological Sciences. 11, 3, p. 460-471 12 p.

Research output: Contribution to journalReview article

75 Scopus citations
2011

Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR)

Li, D., Chen, S., Bellomo, E. A., Tarasov, A. I., Kaut, C., Rutter, G. A. & Li, W. H., Dec 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 52, p. 21063-21068 6 p.

Research output: Contribution to journalArticle

82 Scopus citations

Temporal and spatial regulation of microrna activity with photoactivatable cantimirs

Zheng, G., Cochella, L., Liu, J., Hobert, O. & Li, W. H., Dec 2011, In : ACS Chemical Biology. 6, 12, p. 1332-1338 7 p.

Research output: Contribution to journalArticle

33 Scopus citations
2010

Inhibiting miRNA in Caenorhabditis elegans using a potent and selective antisense reagent

Zheng, G., Ambros, V. & Li, W. H., Apr 1 2010, In : Silence. 1, 1, 9.

Research output: Contribution to journalArticle

14 Scopus citations
1 Scopus citations
2009
10 Scopus citations

Capacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells

Wu, Z., Luby-Phelps, K., Bugde, A., Molyneux, L. A., Denard, B., Li, W. H., Süel, G. M. & Garbers, D. L., Nov 16 2009, In : Journal of Cell Biology. 187, 4, p. 513-524 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Versatile synthesis and rational design of caged morpholinos

Ouyang, X., Shestopalov, I. A., Sinha, S., Zheng, G., Pitt, C. L. W., Li, W. H., Olson, A. J. & Chen, J. K., Sep 23 2009, In : Journal of the American Chemical Society. 131, 37, p. 13255-13269 15 p.

Research output: Contribution to journalArticle

68 Scopus citations
2008

Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP

Guo, Y. M., Chen, S., Shetty, P., Zheng, G., Lin, R. & Li, W. H., Aug 4 2008, In : Nature methods. 5, 9, p. 835-841 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
2007

Cell membrane permeable esters of d-myo-inositol 1,4,5-trisphosphate

Dakin, K. & Li, W. H., Sep 2007, In : Cell Calcium. 42, 3, p. 291-301 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic

Bartz, R., Li, W. H., Venables, B., Zehmer, J. K., Roth, M. R., Welti, R., Anderson, R. G. W., Liu, P. & Chapman, K. D., Apr 1 2007, In : Journal of lipid research. 48, 4, p. 837-847 11 p.

Research output: Contribution to journalArticle

263 Scopus citations

Photoactivatable and water soluble FRET dyes with high uncaging cross section

Zheng, G., Guo, Y. M. & Li, W. H., Sep 5 2007, In : Journal of the American Chemical Society. 129, 35, p. 10616-10617 2 p.

Research output: Contribution to journalArticle

40 Scopus citations
2006

Crafting new cages

Li, W. H., Jan 1 2006, In : Nature methods. 3, 1, p. 13-15 3 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Infrared-LAMP: Two-photon uncaging and imaging of gap junctional communication in three dimensions

Dakin, K. & Li, W. H., Dec 1 2006, In : Nature methods. 3, 12, 1 p.

Research output: Contribution to journalLetter

28 Scopus citations

Local Ca2+ rise near store operated Ca2+ channels inhibits cell coupling during capacitative Ca2+ influx

Dakin, K. & Li, W. H., Jan 1 2006, In : Cell Communication and Adhesion. 13, 1-2, p. 29-39 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2005

A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic β cells

Kang, G., Chepurny, O. G., Rindler, M. J., Collis, L., Chepurny, Z., Li, W. H., Harbeck, M., Roe, M. W. & Holz, G. G., Jul 1 2005, In : Journal of Physiology. 566, 1, p. 173-188 16 p.

Research output: Contribution to journalArticle

99 Scopus citations

A new class of macrocyclic lanthanide complexes for cell labeling and magnetic resonance imaging applications

Zheng, Q., Dai, H., Merritt, M. E., Malloy, C., Pan, C. Y. & Li, W. H., Nov 23 2005, In : Journal of the American Chemical Society. 127, 46, p. 16178-16188 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

LAMP, a new imaging assay of gap junctional communication unveils that Ca2+ influx inhibits cell coupling

Dakin, K., Zhao, Y. & Li, W. H., Jan 1 2005, In : Nature methods. 2, 1, p. 55-62 8 p.

Research output: Contribution to journalArticle

71 Scopus citations
2004

Ca2+-Dependent Glutamate Release Involves Two Classes of Endoplasmic Reticulum Ca2+ Stores in Astrocytes

Hua, X., Malarkey, E. B., Sunjara, V., Rosenwald, S. E., Li, W. H. & Parpura, V., Apr 1 2004, In : Journal of Neuroscience Research. 76, 1, p. 86-97 12 p.

Research output: Contribution to journalArticle

87 Scopus citations

Critical role of PIP5KIγ87 in InsP3-mediated Ca 2+ signaling

Wang, Y. J., Li, W. H., Wang, J., Xu, K., Dong, P., Luo, X. & Yin, H. L., Dec 20 2004, In : Journal of Cell Biology. 167, 6, p. 1005-1010 6 p.

Research output: Contribution to journalArticle

74 Scopus citations

Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 1,4,5-trisphosphate receptor

Wagner, L. E., Li, W. H., Joseph, S. K. & Yule, D. I., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 46242-46252 11 p.

Research output: Contribution to journalArticle

53 Scopus citations

New Caged Coumarin Fluorophores with Extraordinary Uncaging Cross Sections Suitable for Biological Imaging Applications

Zhao, Y., Zheng, Q., Dakin, K., Xu, K., Martinez, M. L. & Li, W. H., Apr 14 2004, In : Journal of the American Chemical Society. 126, 14, p. 4653-4663 11 p.

Research output: Contribution to journalArticle

178 Scopus citations
2003

Co-incident signalling between μ-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: Lack of evidence for Ins(1,4,5)P3 receptor sensitization

Samways, D. S. K., Li, W. H., Conway, S. J., Holmes, A. B., Bootman, M. D. & Henderson, G., Nov 1 2003, In : Biochemical Journal. 375, 3, p. 713-720 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

ET-1 activates Ca2+ sparks in PASMC: Local Ca2+ signaling between inositol trisphosphate and ryanodine receptors

Zhang, W. M., Yip, K. P., Lin, M. J., Shimoda, L. A., Li, W. H. & Sham, J. S. K., Sep 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 3 29-3, p. L680-L690

Research output: Contribution to journalArticle

72 Scopus citations
84 Scopus citations
2002

Mechanistic studies of a calcium-dependent MRI contrast agent

Li, W. H., Parigi, G., Fragai, M., Luchinat, C. & Meade, T. J., Aug 1 2002, In : Inorganic Chemistry. 41, 15, p. 4018-4024 7 p.

Research output: Contribution to journalArticle

141 Scopus citations

The role of inositol 1,4,5,-trisphosphate receptors in Ca2+ signalling and the generation of arrhythmias in rat atrial myocytes

Mackenzie, L., Bootman, M. D., Laine, M., Berridge, M. J., Thuring, J., Holmes, A., Li, W. H. & Lipp, P., Jun 1 2002, In : Journal of Physiology. 541, 2, p. 395-409 15 p.

Research output: Contribution to journalArticle

182 Scopus citations
2000

Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels

Balsinde, J., Balboa, M. A., Li, W. H., Llopis, J. & Dennis, E. A., May 15 2000, In : Journal of Immunology. 164, 10, p. 5398-5402 5 p.

Research output: Contribution to journalArticle

Open Access
65 Scopus citations

Functional InsP3 receptors that may modulate excitation-contraction coupling in the heart

Lipp, P., Laine, M., Tovey, S. C., Burrell, K. M., Berridge, M. J., Li, W. & Bootman, M. D., Aug 1 2000, In : Current Biology. 10, 15, p. 939-942 4 p.

Research output: Contribution to journalArticle

183 Scopus citations

Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization

Collins, T. J., Lipp, P., Berridge, M. J., Li, W. & Bootman, M. D., Apr 15 2000, In : Biochemical Journal. 347, 2, p. 593-600 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Microscopic properties of elementary Ca2+ release sites in non-excitable cells

Thomas, D., Lipp, P., Tovey, S. C., Berridge, M. J., Li, W., Tsien, R. Y. & Bootman, M. D., Jan 1 2000, In : Current Biology. 10, 1, p. 8-15 8 p.

Research output: Contribution to journalArticle

95 Scopus citations
1999

A calcium-sensitive magnetic resonance imaging contrast agent [18]

Li, W. H., Fraser, S. E. & Meade, T. J., Feb 17 1999, In : Journal of the American Chemical Society. 121, 6, p. 1413-1414 2 p.

Research output: Contribution to journalLetter

245 Scopus citations
1998

2-Deoxy derivative is a partial agonist of the intracellular messenger inositol 3,4,5,6-tetrakisphosphate in the epithelial cell line T84

Rudolf, M. T., Li, W. H., Wolfson, N., Traynor-Kaplan, A. E. & Schultz, C., Sep 10 1998, In : Journal of Medicinal Chemistry. 41, 19, p. 3635-3644 10 p.

Research output: Contribution to journalArticle

22 Scopus citations