• 3650 Citations
  • 30 h-Index
19972017
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Research Output 1997 2017

  • 3650 Citations
  • 30 h-Index
  • 48 Article
  • 2 Chapter
2017
38 Citations (Scopus)

Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

Kim, J., Okamoto, H., Huang, Z. J., Anguiano, G., Chen, S., Liu, Q., Cavino, K., Xin, Y., Na, E., Hamid, R., Lee, J., Zambrowicz, B., Unger, R. H., Murphy, A. J., Xu, Y., Yancopoulos, G. D., Li, W-H. & Gromada, J., Jun 6 2017, In : Cell Metabolism. 25, 6, p. 1348-1361.e8

Research output: Contribution to journalArticle

Glucagon Receptors
Amino Acid Transport Systems
Glucagon
Hyperplasia
Amino Acids

TargetLink, a new method for identifying the endogenous target set of a specific microRNA in intact living cells

Xu, Y., Chen, Y., Li, D., Liu, Q., Xuan, Z. & Li, W. H., Feb 1 2017, In : RNA Biology. 14, 2, p. 259-274 16 p.

Research output: Contribution to journalArticle

MicroRNAs
Genes
Small Untranslated RNA
Colorectal Neoplasms
Seeds
2016

Fluorescent sensors for imaging Zinc dynamics in biological fluids

Li, W. H., Apr 19 2016, Optical Probes in Biology. CRC Press, p. 291-315 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Zinc
zinc
Imaging techniques
Fluids
fluids
20 Citations (Scopus)

MitoNEET-Parkin effects in pancreatic α- and β-cells, cellular survival, and intrainsular cross talk

Kusminski, C., Chen, S., Ye, R., Sun, K., Wang, Q. A., Spurgin, S. B., Sanders, P. E., Brozinick, J. T., Geldenhuys, W. J., Li, W-H., Unger, R. H. & Scherer, P. E., Jun 1 2016, In : Diabetes. 65, 6, p. 1534-1555 22 p.

Research output: Contribution to journalArticle

Cell Survival
Insulin
Hyperglycemia
Glucose
Glucose Intolerance
28 Citations (Scopus)

Molecular genetic regulation of Slc30a8/ZnT8 reveals a positive association with glucose tolerance

Mitchell, R. K., Hu, M., Chabosseau, P. L., Cane, M. C., Meur, G., Bellomo, E. A., Carzaniga, R., Collinson, L. M., Li, W. H., Hodson, D. J. & Rutter, G. A., Jan 1 2016, In : Molecular Endocrinology. 30, 1, p. 77-91 15 p.

Research output: Contribution to journalArticle

Molecular Biology
Glucose
Insulin
Type 2 Diabetes Mellitus
Islets of Langerhans

Probes for monitoring regulated exocytosis

Li, W. H., Dec 17 2016, (Accepted/In press) In : Cell Calcium.

Research output: Contribution to journalArticle

Exocytosis
Neurobiology
Endocrinology
Secretory Vesicles
Allergy and Immunology

Tracking dynamic gap junctional coupling in live cells by local photoactivation and fluorescence imaging

Yang, S. & Li, W. H., 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1437. p. 181-191 11 p. (Methods in Molecular Biology; vol. 1437).

Research output: Chapter in Book/Report/Conference proceedingChapter

Optical Imaging
Coloring Agents
Molecular Probes
Gap Junctions
Fluorescent Dyes
32 Citations (Scopus)

Zinc-sensitive MRI contrast agent detects differential release of Zn(II) ions from the healthy vs. malignant mouse prostate

Jordan, M. V. C., Lo, S. T., Chen, S., Preihs, C., Chirayil, S., Zhang, S., Kapur, P., Li, W. H., De Leon-Rodriguez, L. M., Lubag, A. J. M., Rofsky, N. M. & Sherry, A. D., Sep 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. E5464-E5471

Research output: Contribution to journalArticle

Contrast Media
Zinc
Prostate
Ions
Glucose
2015
29 Citations (Scopus)

Genetic targeting of a small fluorescent zinc indicator to cell surface for monitoring zinc secretion

Li, D., Liu, L. & Li, W. H., Apr 17 2015, In : ACS Chemical Biology. 10, 4, p. 1054-1063 10 p.

Research output: Contribution to journalArticle

Zinc
Islets of Langerhans
Imaging techniques
Monitoring
Paracrine Communication
6 Citations (Scopus)

GLP-1 Receptor Mediated Targeting of a Fluorescent Zn<sup>2+</sup> Sensor to Beta Cell Surface for Imaging Insulin/Zn<sup>2+</sup> Release

Li, D., Huang, Z., Chen, S., Hu, Z. & Li, W. H., Aug 19 2015, In : Bioconjugate Chemistry. 26, 8, p. 1443-1450 8 p.

Research output: Contribution to journalArticle

Insulin
Imaging techniques
Peptides
Islets of Langerhans
Sensors
2014
55 Citations (Scopus)

ADCY5 couples glucose to insulin secretion in human islets

Hodson, D. J., Mitchell, R. K., Marselli, L., Pullen, T. J., Brias, S. G., Semplici, F., Everett, K. L., Cooper, D. M. F., Bugliani, M., Marchetti, P., Lavallard, V., Bosco, D., Piemonti, L., Johnson, P. R., Hughes, S. J., Li, D., Li, W. H., Shapiro, A. M. J. & Rutter, G. A., 2014, In : Diabetes. 63, 9, p. 3009-3021 13 p.

Research output: Contribution to journalArticle

Insulin
Glucose
Glucagon-Like Peptide 1
Type 2 Diabetes Mellitus
Fasting
2013
6 Citations (Scopus)

Fluorescent probes for monitoring regulated secretion

Li, W. H. & Li, D., Aug 2013, In : Current Opinion in Chemical Biology. 17, 4, p. 672-681 10 p.

Research output: Contribution to journalArticle

Endocrinology
Physiology
Fluorescent Dyes
Telecommunication networks
Animals
104 Citations (Scopus)

Improved orange and red Ca2+ indicators and photophysical considerations for optogenetic applications

Wu, J., Liu, L., Matsuda, T., Zhao, Y., Rebane, A., Drobizhev, M., Chang, Y. F., Araki, S., Arai, Y., March, K., Hughes, T. E., Sagou, K., Miyata, T., Nagai, T., Li, W. H. & Campbell, R. E., Jun 19 2013, In : ACS Chemical Neuroscience. 4, 6, p. 963-972 10 p.

Research output: Contribution to journalArticle

Optogenetics
Artifacts
Chemical activation
Protein Engineering
Neocortex
100 Citations (Scopus)

Lipotoxicity disrupts incretin-regulated human β cell connectivity

Hodson, D. J., Mitchell, R. K., Bellomo, E. A., Sun, G., Vinet, L., Meda, P., Li, D., Li, W. H., Bugliani, M., Marchetti, P., Bosco, D., Piemonti, L., Johnson, P., Hughes, S. J. & Rutter, G. A., Oct 1 2013, In : Journal of Clinical Investigation. 123, 10, p. 4182-4194 13 p.

Research output: Contribution to journalArticle

Incretins
Glucagon-Like Peptide 1
Glucose
Insulin
Peptides
2012
26 Citations (Scopus)

Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans

Schumacher, J. A., Hsieh, Y. W., Chen, S., Pirri, J. K., Alkema, M. J., Li, W. H., Chang, C. & Chuang, C. F., Nov 15 2012, In : Development (Cambridge). 139, 22, p. 4191-4201 11 p.

Research output: Contribution to journalArticle

Calcium Signaling
Gap Junctions
Calcium
Neurons
Vertebrates
66 Citations (Scopus)

Photoactivatable fluorophores and techniques for biological imaging applications

Li, W. H. & Zheng, G., Mar 2012, In : Photochemical and Photobiological Sciences. 11, 3, p. 460-471 12 p.

Research output: Contribution to journalArticle

Coumarins
Fluorophores
Imaging techniques
Molecular Probes
Biological systems
2011
71 Citations (Scopus)

Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR)

Li, D., Chen, S., Bellomo, E. A., Tarasov, A. I., Kaut, C., Rutter, G. A. & Li, W. H., Dec 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 52, p. 21063-21068 6 p.

Research output: Contribution to journalArticle

Zinc
Insulin
Cell Engineering
Intercellular Junctions
Fura-2
32 Citations (Scopus)

Temporal and spatial regulation of microRNA activity with photoactivatable cantimirs.

Zheng, G., Cochella, L., Liu, J., Hobert, O. & Li, W. H., Dec 16 2011, In : ACS Chemical Biology. 6, 12, p. 1332-1338 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Small Untranslated RNA
Antisense Oligonucleotides
Physiology
Neurology
2010
14 Citations (Scopus)

Inhibiting miRNA in Caenorhabditis elegans using a potent and selective antisense reagent

Zheng, G., Ambros, V. & Li, W. H., Apr 1 2010, In : Silence. 1, 1, 9.

Research output: Contribution to journalArticle

Caenorhabditis elegans
MicroRNAs
Dextrans
Oligoribonucleotides
Vulva
1 Citation (Scopus)
Optics and Photonics
Inositol 1,4,5-Trisphosphate
Second Messenger Systems
Photons
Fluorescence Microscopy
2009
10 Citations (Scopus)
Molecular Probes
Optical Imaging
Fluorescent Dyes
Cell Communication
Fluorescence
22 Citations (Scopus)

Capacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells

Wu, Z., Luby-Phelps, K., Bugde, A., Molyneux, L. A., Denard, B., Li, W. H., Süel, G. M. & Garbers, D. L., Nov 16 2009, In : Journal of Cell Biology. 187, 4, p. 513-524 12 p.

Research output: Contribution to journalArticle

Stem Cells
Spermatogenesis
Germ Cells
66 Citations (Scopus)

Versatile synthesis and rational design of caged morpholinos

Ouyang, X., Shestopalov, I. A., Sinha, S., Zheng, G., Pitt, C. L. W., Li, W. H., Olson, A. J. & Chen, J. K., Sep 23 2009, In : Journal of the American Chemical Society. 131, 37, p. 13255-13269 15 p.

Research output: Contribution to journalArticle

Morpholinos
Genes
Oligonucleotides
Technology
Developmental Genes
2008
30 Citations (Scopus)

Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP

Guo, Y. M., Chen, S., Shetty, P., Zheng, G., Lin, R. & Li, W. H., 2008, In : Nature Methods. 5, 9, p. 835-841 7 p.

Research output: Contribution to journalArticle

Molecular Probes
Dextrans
Fluorescent Dyes
Chemical activation
Imaging techniques
2007
34 Citations (Scopus)

Cell membrane permeable esters of d-myo-inositol 1,4,5-trisphosphate

Dakin, K. & Li, W. H., Sep 2007, In : Cell Calcium. 42, 3, p. 291-301 11 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Esters
Cell Membrane
Inositol 1,4,5-Trisphosphate Receptors
NIH 3T3 Cells
249 Citations (Scopus)

Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic

Bartz, R., Li, W. H., Venables, B., Zehmer, J. K., Roth, M. R., Welti, R., Anderson, R. G. W., Liu, P. & Chapman, K. D., Apr 2007, In : Journal of Lipid Research. 48, 4, p. 837-847 11 p.

Research output: Contribution to journalArticle

Ether
Phospholipids
Lipids
Phosphatidylcholines
Mass Spectrometry
40 Citations (Scopus)

Photoactivatable and water soluble FRET dyes with high uncaging cross section

Zheng, G., Guo, Y. M. & Li, W. H., Sep 5 2007, In : Journal of the American Chemical Society. 129, 35, p. 10616-10617 2 p.

Research output: Contribution to journalArticle

Fluoresceins
Coloring Agents
Xanthenes
Dyes
Molecular Probes
2006
2 Citations (Scopus)

Crafting new cages

Li, W. H., Jan 2006, In : Nature Methods. 3, 1, p. 13-15 3 p.

Research output: Contribution to journalArticle

Photolysis
Chromophores
Photons
Ions
Calcium
28 Citations (Scopus)

Infrared-LAMP: Two-photon uncaging and imaging of gap junctional communication in three dimensions

Dakin, K. & Li, W. H., Dec 2006, In : Nature Methods. 3, 12, p. 959 1 p.

Research output: Contribution to journalArticle

Image enhancement
Photons
Infrared radiation
Imaging techniques
Communication
9 Citations (Scopus)

Local Ca2+ rise near store operated Ca2+ channels inhibits cell coupling during capacitative Ca2+ influx

Dakin, K. & Li, W. H., Jan 2006, In : Cell Communication and Adhesion. 13, 1-2, p. 29-39 11 p.

Research output: Contribution to journalArticle

Connexin 43
Fluorescence
Cells
Imaging techniques
Ionomycin
2005
95 Citations (Scopus)

A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic β cells

Kang, G., Chepurny, O. G., Rindler, M. J., Collis, L., Chepurny, Z., Li, W. H., Harbeck, M., Roe, M. W. & Holz, G. G., Jul 1 2005, In : Journal of Physiology. 566, 1, p. 173-188 16 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Cyclic AMP-Dependent Protein Kinases
Second Messenger Systems
Insulin
Guanine Nucleotide Exchange Factors
55 Citations (Scopus)

A new class of macrocyclic lanthanide complexes for cell labeling and magnetic resonance imaging applications

Zheng, Q., Dai, H., Merritt, M. E., Malloy, C., Pan, C. Y. & Li, W. H., Nov 23 2005, In : Journal of the American Chemical Society. 127, 46, p. 16178-16188 11 p.

Research output: Contribution to journalArticle

Lanthanoid Series Elements
Magnetic resonance
Rare earth elements
Labeling
Personal digital assistants
68 Citations (Scopus)

LAMP, a new imaging assay of gap junctional communication unveils that Ca2+ influx inhibits cell coupling

Dakin, K., Zhao, Y. & Li, W. H., Jan 2005, In : Nature Methods. 2, 1, p. 55-62 8 p.

Research output: Contribution to journalArticle

Gap Junctions
Assays
Coloring Agents
Imaging techniques
Communication
2004
87 Citations (Scopus)

Ca2+-Dependent Glutamate Release Involves Two Classes of Endoplasmic Reticulum Ca2+ Stores in Astrocytes

Hua, X., Malarkey, E. B., Sunjara, V., Rosenwald, S. E., Li, W. H. & Parpura, V., Apr 1 2004, In : Journal of Neuroscience Research. 76, 1, p. 86-97 12 p.

Research output: Contribution to journalArticle

Astrocytes
Endoplasmic Reticulum
Glutamic Acid
Ryanodine
Extracellular Space
72 Citations (Scopus)

Critical role of PIP5KIγ87 in InsP3-mediated Ca 2+ signaling

Wang, Y. J., Li, W. H., Wang, J., Xu, K., Dong, P., Luo, X. & Yin, H. L., Dec 20 2004, In : Journal of Cell Biology. 167, 6, p. 1005-1010 6 p.

Research output: Contribution to journalArticle

RNA Interference
G-Protein-Coupled Receptors
Protein Isoforms
Focal Adhesions
Inositol 1,4,5-Trisphosphate
51 Citations (Scopus)

Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 1,4,5-trisphosphate receptor

Wagner, L. E., Li, W. H., Joseph, S. K. & Yule, D. I., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 46242-46252 11 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Phosphorylation
Cyclic AMP-Dependent Protein Kinases
Cells
Mutation
174 Citations (Scopus)

New Caged Coumarin Fluorophores with Extraordinary Uncaging Cross Sections Suitable for Biological Imaging Applications

Zhao, Y., Zheng, Q., Dakin, K., Xu, K., Martinez, M. L. & Li, W. H., Apr 14 2004, In : Journal of the American Chemical Society. 126, 14, p. 4653-4663 11 p.

Research output: Contribution to journalArticle

Fluorophores
Photolysis
Imaging techniques
Photons
Fluorescence
2003
13 Citations (Scopus)

Co-incident signalling between μ-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: Lack of evidence for Ins(1,4,5)P3 receptor sensitization

Samways, D. S. K., Li, W. H., Conway, S. J., Holmes, A. B., Bootman, M. D. & Henderson, G., Nov 1 2003, In : Biochemical Journal. 375, 3, p. 713-720 8 p.

Research output: Contribution to journalArticle

Muscarinic M3 Receptors
Ala(2)-MePhe(4)-Gly(5)-enkephalin
Opioid Analgesics
Opioid Receptors
Chemical activation
69 Citations (Scopus)

ET-1 activates Ca2+ sparks in PASMC: Local Ca2+ signaling between inositol trisphosphate and ryanodine receptors

Zhang, W. M., Yip, K. P., Lin, M. J., Shimoda, L. A., Li, W. H. & Sham, J. S. K., Sep 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 3 29-3

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Endothelin-1
Inositol
Inositol 1,4,5-Trisphosphate Receptors
Smooth Muscle Myocytes
83 Citations (Scopus)
Inositol 1,4,5-Trisphosphate Receptors
Phosphorylation
Cyclic Nucleotides
Cyclic AMP-Dependent Protein Kinases
Serine
2002
137 Citations (Scopus)

Mechanistic studies of a calcium-dependent MRI contrast agent

Li, W. H., Parigi, G., Fragai, M., Luchinat, C. & Meade, T. J., 2002, In : Inorganic Chemistry. 41, 15, p. 4018-4024 7 p.

Research output: Contribution to journalArticle

Magnetic resonance imaging
Contrast Media
calcium
Ions
Calcium
178 Citations (Scopus)

The role of inositol 1,4,5,-trisphosphate receptors in Ca2+ signalling and the generation of arrhythmias in rat atrial myocytes

Mackenzie, L., Bootman, M. D., Laine, M., Berridge, M. J., Thuring, J., Holmes, A., Li, W. H. & Lipp, P., Jun 1 2002, In : Journal of Physiology. 541, 2, p. 395-409 15 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Endothelin-1
Muscle Cells
Cardiac Arrhythmias
Adrenergic Agonists
2000
64 Citations (Scopus)

Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels

Balsinde, J., Balboa, M. A., Li, W. H., Llopis, J. & Dennis, E. A., May 15 2000, In : Journal of Immunology. 164, 10, p. 5398-5402 5 p.

Research output: Contribution to journalArticle

Group IV Phospholipases A2
Phosphatidylinositols
Phosphatidylinositol 4,5-Diphosphate
Calcium
Arachidonic Acid
178 Citations (Scopus)

Functional InsP3 receptors that may modulate excitation-contraction coupling in the heart

Lipp, P., Laine, M., Tovey, S. C., Burrell, K. M., Berridge, M. J., Li, W. & Bootman, M. D., Aug 1 2000, In : Current Biology. 10, 15, p. 939-942 4 p.

Research output: Contribution to journalArticle

Excitation Contraction Coupling
Ryanodine Receptor Calcium Release Channel
Muscle Cells
Esters
heart
61 Citations (Scopus)

Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization

Collins, T. J., Lipp, P., Berridge, M. J., Li, W. & Bootman, M. D., Apr 15 2000, In : Biochemical Journal. 347, 2, p. 593-600 8 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Depolarization
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone
Hormones
Cell Count
93 Citations (Scopus)

Microscopic properties of elementary Ca2+ release sites in non-excitable cells

Thomas, D., Lipp, P., Tovey, S. C., Berridge, M. J., Li, W., Tsien, R. Y. & Bootman, M. D., Jan 1 2000, In : Current Biology. 10, 1, p. 8-15 8 p.

Research output: Contribution to journalArticle

Pacemakers
calcium
Thimerosal
Inositol 1,4,5-Trisphosphate Receptors
cells
1999
238 Citations (Scopus)

A calcium-sensitive magnetic resonance imaging contrast agent [18]

Li, W. H., Fraser, S. E. & Meade, T. J., Feb 17 1999, In : Journal of the American Chemical Society. 121, 6, p. 1413-1414 2 p.

Research output: Contribution to journalArticle

Magnetic resonance
Contrast Media
Calcium
Imaging techniques
1998
22 Citations (Scopus)

2-Deoxy derivative is a partial agonist of the intracellular messenger inositol 3,4,5,6-tetrakisphosphate in the epithelial cell line T84

Rudolf, M. T., Li, W. H., Wolfson, N., Traynor-Kaplan, A. E. & Schultz, C., Sep 10 1998, In : Journal of Medicinal Chemistry. 41, 19, p. 3635-3644 10 p.

Research output: Contribution to journalArticle

Epithelial Cells
Derivatives
Cell Line
Inositol
Membranes
737 Citations (Scopus)

Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression

Li, W. H., Llopis, J., Whitney, M., Zlokarnik, G. & Tsien, R. Y., Apr 30 1998, In : Nature. 392, 6679, p. 936-941 6 p.

Research output: Contribution to journalArticle

Esters
Calcium
Gene Expression
NFATC Transcription Factors
Inositol 1,4,5-Trisphosphate
1997
57 Citations (Scopus)

Membrane-permeant esters of inositol polyphosphates, chemical syntheses and biological applications

Li, W., Schultz, C., Llopis, J. & Tsien, R. Y., Sep 1997, In : Tetrahedron. 53, 35, p. 12017-12040 24 p.

Research output: Contribution to journalArticle

Polyphosphates
Inositol
Esters
Membranes
Inositol 1,4,5-Trisphosphate