If you made any changes in Pure, your changes will be visible here soon.

Research Output 2002 2019

  • 2132 Citations
  • 14 h-Index
  • 20 Article
  • 1 Comment/debate
  • 1 Short survey
2019

Manipulation by Methylation: Garnishing mRNAs with m6Am

Doxtader, K. A. & Nam, Y., Aug 8 2019, In : Molecular cell. 75, 3, p. 417-418 2 p.

Research output: Contribution to journalShort survey

Transcriptome
Methylation
Messenger RNA
2018

Erratum to: Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs (Nature Communications, (2017), 8, 1, (1737), 10.1038/s41467-017-01713-y)

Partin, A. C., Ngo, T. D., Herrell, E., Jeong, B. C., Hon, G. & Nam, Y., Dec 1 2018, In : Nature Communications. 9, 1, 3852.

Research output: Contribution to journalComment/debate

MicroRNAs
Heme
positioning
communication
document markup languages
10 Citations (Scopus)

Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28

Wang, L., Rowe, R. G., Jaimes, A., Yu, C., Nam, Y., Pearson, D. S., Zhang, J., Xie, X., Marion, W., Heffron, G. J., Daley, G. Q. & Sliz, P., Jun 5 2018, In : Cell Reports. 23, 10, p. 3091-3101 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Zinc
Shock
Molecules
Fluorescence Polarization
13 Citations (Scopus)

Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor

Doxtader, K. A., Wang, P., Scarborough, A. M., Seo, D., Conrad, N. K. & Nam, Y., Jan 1 2018, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Homeostasis
RNA
Methyltransferases
Messenger RNA
2017
11 Citations (Scopus)

Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs

Partin, A. C., Ngo, T. D., Herrell, E., Jeong, B. C., Hon, G. & Nam, Y., Dec 1 2017, In : Nature Communications. 8, 1, 1737.

Research output: Contribution to journalArticle

microprocessors
MicroRNAs
Heme
positioning
proteins
17 Citations (Scopus)

LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation

Wang, L., Nam, Y., Lee, A. K., Yu, C., Roth, K., Chen, C., Ransey, E. M. & Sliz, P., Mar 14 2017, In : Cell Reports. 18, 11, p. 2664-2675 12 p.

Research output: Contribution to journalArticle

Zinc
Tissue regeneration
RNA-Binding Proteins
MicroRNAs
Metabolism
2016
57 Citations (Scopus)

Data publication with the structural biology data grid supports live analysis

Meyer, P. A., Socias, S., Key, J., Ransey, E., Tjon, E. C., Buschiazzo, A., Lei, M., Botka, C., Withrow, J., Neau, D., Rajashankar, K., Anderson, K. S., Baxter, R. H., Blacklow, S. C., Boggon, T. J., Bonvin, A. M. J. J., Borek, D., Brett, T. J., Caflisch, A., Chang, C. I. & 50 others, Chazin, W. J., Corbett, K. D., Cosgrove, M. S., Crosson, S., Dhe-Paganon, S., Di Cera, E., Drennan, C. L., Eck, M. J., Eichman, B. F., Fan, Q. R., Ferré-D'Amaré, A. R., Fromme, J. C., Garcia, K. C., Gaudet, R., Gong, P., Harrison, S. C., Heldwein, E. E., Jia, Z., Keenan, R. J., Kruse, A. C., Kvansakul, M., McLellan, J. S., Modis, Y., Nam, Y., Otwinowski, Z., Pai, E. F., Pereira, P. J. B., Petosa, C., Raman, C. S., Rapoport, T. A., Roll-Mecak, A., Rosen, M. K., Rudenko, G., Schlessinger, J., Schwartz, T. U., Shamoo, Y., Sondermann, H., Tao, Y. J., Tolia, N. H., Tsodikov, O. V., Westover, K. D., Wu, H., Foster, I., Fraser, J. S., Maia, F. R. N. C., Gonen, T., Kirchhausen, T., Diederichs, K., Crosas, M. & Sliz, P., Mar 7 2016, In : Nature Communications. 7, 10882.

Research output: Contribution to journalArticle

biology
Publications
grids
biomedical data
Diffraction
13 Citations (Scopus)

HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing

Liu, H., Liang, C., Kollipara, R. K., Matsui, M., Ke, X., Jeong, B. C., Wang, Z., Yoo, K. S., Yadav, G. P., Kinch, L. N., Grishin, N. V., Nam, Y., Corey, D. R., Kittler, R. & Liu, Q., Feb 8 2016, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

MicroRNAs
Chromatin
Microcomputers
Histones
Proteins
160 Citations (Scopus)

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

Wang, P., Doxtader, K. A. & Nam, Y., Jul 21 2016, In : Molecular Cell. 63, 2, p. 306-317 12 p.

Research output: Contribution to journalArticle

Methyltransferases
S-Adenosylhomocysteine
S-Adenosylmethionine
Adenosine
Methylation
2012
14 Citations (Scopus)

A grid-enabled web service for low-resolution crystal structure refinement

Odonovan, D. J., Stokes-Rees, I., Nam, Y., Blacklow, S. C., Schröder, G. F., Brunger, A. T. & Sliz, P., Mar 2012, In : Acta Crystallographica Section D: Biological Crystallography. 68, 3, p. 261-267 7 p.

Research output: Contribution to journalArticle

Running
X-Rays
Datasets
38 Citations (Scopus)

Conformational locking upon cooperative assembly of notch transcription complexes

Choi, S. H., Wales, T. E., Nam, Y., O'Donovan, D. J., Sliz, P., Engen, J. R. & Blacklow, S. C., Feb 8 2012, In : Structure. 20, 2, p. 340-349 10 p.

Research output: Contribution to journalArticle

Ankyrins
Ankyrin Repeat
DNA
DNA Probes
Dimerization
2011
208 Citations (Scopus)

Molecular basis for interaction of let-7 MicroRNAs with Lin28

Nam, Y., Chen, C., Gregory, R. I., Chou, J. J. & Sliz, P., Nov 23 2011, In : Cell. 147, 5, p. 1080-1091 12 p.

Research output: Contribution to journalArticle

MicroRNAs
RNA
Small Untranslated RNA
Gene expression
Nuclear magnetic resonance spectroscopy
5 Citations (Scopus)

Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation

Aster, J. C., Bodnar, N., Xu, L., Karnell, F., Milholland, J. M., Maillard, I., Histen, G., Nam, Y., Blacklow, S. C. & Pear, W. S., Oct 13 2011, In : PLoS One. 6, 10, e25645.

Research output: Contribution to journalArticle

Ankyrin Repeat
ankyrins
T-cells
transcriptional activation
Transcriptional Activation
230 Citations (Scopus)

Structure of human O-GlcNAc transferase and its complex with a peptide substrate

Lazarus, M. B., Nam, Y., Jiang, J., Sliz, P. & Walker, S., Jan 27 2011, In : Nature. 469, 7331, p. 564-569 6 p.

Research output: Contribution to journalArticle

Uridine Diphosphate N-Acetylglucosamine
Uridine Diphosphate
Protamine Kinase
Peptides
Mitochondrial Proteins
2008
91 Citations (Scopus)

A role for the two-helix finger of the SecA ATPase in protein translocation

Erlandson, K. J., Miller, S. B. M., Nam, Y., Osborne, A. R., Zimmer, J. & Rapoport, T. A., Oct 16 2008, In : Nature. 455, 7215, p. 984-987 4 p.

Research output: Contribution to journalArticle

Protein Transport
Fingers
Adenosine Triphosphatases
Peptides
Tyrosine
293 Citations (Scopus)

Structure of a complex of the ATPase SecA and the protein-translocation channel

Zimmer, J., Nam, Y. & Rapoport, T. A., Oct 16 2008, In : Nature. 455, 7215, p. 936-943 8 p.

Research output: Contribution to journalArticle

Protein Transport
Adenosine Triphosphatases
Thermotoga maritima
Peptides
Protein Sorting Signals
2007
104 Citations (Scopus)

Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription

Nam, Y., Sliz, P., Pear, W. S., Aster, J. C. & Blacklow, S. C., Feb 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 7, p. 2103-2108 6 p.

Research output: Contribution to journalArticle

Genes
Notch Receptors
Drosophila
Transcription Factors
Binding Sites
2006
69 Citations (Scopus)

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1

Chiang, M. Y., Xu, M. L., Histen, G., Shestova, O., Roy, M., Nam, Y., Blacklow, S. C., Sacks, D. B., Pear, W. S. & Aster, J. C., Aug 2006, In : Molecular and Cellular Biology. 26, 16, p. 6261-6271 11 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Alleles
Mutation
Conserved Sequence
Sequence Deletion
292 Citations (Scopus)

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

Nam, Y., Sliz, P., Song, L., Aster, J. C. & Blacklow, S. C., Mar 10 2006, In : Cell. 124, 5, p. 973-983 11 p.

Research output: Contribution to journalArticle

Transcription
Transcriptional Activation
Genes
Chemical activation
Ankyrins
2003
298 Citations (Scopus)

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of NOTCH signaling

Weng, A. P., Nam, Y., Wolfe, M. S., Pear, W. S., Griffin, J. D., Blacklow, S. C. & Aster, J. C., Jan 2003, In : Molecular and Cellular Biology. 23, 2, p. 655-664 10 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Presenilins
Growth
Notch Receptors
Transformed Cell Line
150 Citations (Scopus)

Structural requirements for assembly of the CSL·intracellular Notch1·Mastermind-like 1 transcriptional activation complex

Nam, Y., Weng, A. P., Aster, J. C. & Blacklow, S. C., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 21232-21239 8 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Chemical activation
DNA
Ternary Complex Factors
Transcription Factors
2002
59 Citations (Scopus)

Notch signaling as a therapeutic target

Nam, Y., Aster, J. C. & Blacklow, S. C., Aug 1 2002, In : Current Opinion in Chemical Biology. 6, 4, p. 501-509 9 p.

Research output: Contribution to journalArticle

Notch Receptors
Signal transduction
Neoplastic Stem Cells
Transcription
Stem cells