α-melanocyte-stimulating hormone and acute renal failure

Yukimasa Kohda, Hsi Chiao, Robert A. Star

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

α-Melanocyte-stimulating hormone (MSH) is an endogenous anti- inflammatory cytokine that inhibits all major forms of inflammation. α-MSH level is increased at sites of r inflammation in humans, and is produced in the pituitary and in macrophages. The effects of α-MSH are mediated by c melanocortin receptors found on macrophages, neutrophils, and renal tubules. α-MSH inhibited ischemic acute renal r failure in mice and rats, even when started 6 h after injury. α-MSH acts, in part, by inhibiting the maladaptive activation of genes that cause inflammatory and cytotoxic renal injury. However, α-MSH is effective even in the absence of neutrophils, suggesting that α-MSH also acts directly on renal tubules.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalCurrent opinion in nephrology and hypertension
Volume7
Issue number4
DOIs
StatePublished - Aug 3 1998

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ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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