γ-Aminobutyric acid receptors in normal human brain and Huntington disease

P. C. van Ness, A. E. Watkins, M. O. Bergman, W. W. Tourtellotte, R. W. Olsen

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

CABA receptor binding curves were measured in well-washed membrane homogenates from eleven, regions of normal human brain and four regions from brains of Huntington disease patients. Computer analysis suggested two populations of receptor sites of different affinity (KD = 10 nM and 240 nM) present in all brain regions but in variable quantity (cerebellar cortex and cerebral cortex > basal ganglia > deeper brain structures). “he number of GABA receptor sites in the caudate-putamen region of Huntington brain was less than normal, but the number of sites was increased in Huntington disease substantia nigra. No differences from normal were found in cerebellar cortex or frontal cortex from Huntington disease, and no significant changes in binding affinity were observed for any of the four regions tested under the conditions used.

Original languageEnglish (US)
Pages (from-to)63-68
Number of pages6
JournalNeurology
Volume32
Issue number1
StatePublished - Jan 1982

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'γ-Aminobutyric acid receptors in normal human brain and Huntington disease'. Together they form a unique fingerprint.

Cite this