κ/λ shifts do not occur during maturation of murine B cells

K. L. McGuire, E. S. Vitetta

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27 Scopus citations

Abstract

We have used highly specific affinity-purified antibodies against mouse κ- and λ-chains in conjunction with both immunofluorescence analysis on the FACS and enzymatic radioiodination of murine splenocytes and bone marrow cells. Our results indicate that the κ/λ ratio of cell surface immunoglobulin is constant during the ontogenetic development of B cells, i.e., a shift in the κ/λ ratio does not occur during B cell maturation. Our results suggest that the events controlling κ and λ expression on murine B cells are decided very early in ontogeny, before significant antigenic selection.

Original languageEnglish (US)
Pages (from-to)1670-1673
Number of pages4
JournalJournal of Immunology
Volume127
Issue number4
Publication statusPublished - 1981

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ASJC Scopus subject areas

  • Immunology

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