2-Cyanopyridazin-3(2H)-ones: Effective and chemoselective electrophilic cyanating agents

Jeum Jong Kim, Deok Heon Kweon, Su Dong Cho, Ho Kyun Kim, Eun Young Jung, Sang Gyeong Lee, J R Falck, Yong Jin Yoon

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

2-Cyanopyridazin-3(2H)-ones are novel, effective, selective and electrophilic cyanating agents. A variety of amino, thiol and carbon nucleophiles are chemoselectively N-, S- or C-cyanated in excellent yield using 2-cyanopyridanzin-3(2H)-ones in water or tetrahydrofuran.

Original languageEnglish (US)
Pages (from-to)5889-5894
Number of pages6
JournalTetrahedron
Volume61
Issue number24
DOIs
StatePublished - Jun 13 2005

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Nucleophiles
Sulfhydryl Compounds
Carbon
Water
tetrahydrofuran

Keywords

  • 2-Cyanopyridazin-3(2H)- ones
  • Electrophilic cyanating agent
  • N-, S- or C-cyanation

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Kim, J. J., Kweon, D. H., Cho, S. D., Kim, H. K., Jung, E. Y., Lee, S. G., ... Yoon, Y. J. (2005). 2-Cyanopyridazin-3(2H)-ones: Effective and chemoselective electrophilic cyanating agents. Tetrahedron, 61(24), 5889-5894. https://doi.org/10.1016/j.tet.2005.03.138

2-Cyanopyridazin-3(2H)-ones : Effective and chemoselective electrophilic cyanating agents. / Kim, Jeum Jong; Kweon, Deok Heon; Cho, Su Dong; Kim, Ho Kyun; Jung, Eun Young; Lee, Sang Gyeong; Falck, J R; Yoon, Yong Jin.

In: Tetrahedron, Vol. 61, No. 24, 13.06.2005, p. 5889-5894.

Research output: Contribution to journalArticle

Kim, JJ, Kweon, DH, Cho, SD, Kim, HK, Jung, EY, Lee, SG, Falck, JR & Yoon, YJ 2005, '2-Cyanopyridazin-3(2H)-ones: Effective and chemoselective electrophilic cyanating agents', Tetrahedron, vol. 61, no. 24, pp. 5889-5894. https://doi.org/10.1016/j.tet.2005.03.138
Kim, Jeum Jong ; Kweon, Deok Heon ; Cho, Su Dong ; Kim, Ho Kyun ; Jung, Eun Young ; Lee, Sang Gyeong ; Falck, J R ; Yoon, Yong Jin. / 2-Cyanopyridazin-3(2H)-ones : Effective and chemoselective electrophilic cyanating agents. In: Tetrahedron. 2005 ; Vol. 61, No. 24. pp. 5889-5894.
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