Abstract
Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into trans-complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the lipid rearrangements of fusion.
Original language | English (US) |
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Pages (from-to) | 707-711 |
Number of pages | 5 |
Journal | Molecular biology of the cell |
Volume | 28 |
Issue number | 6 |
DOIs | |
State | Published - Mar 15 2017 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology