A cascade of multiple proteins and lipids catalyzes membrane fusion

William Wickner, Jose Rizo-Rey

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into trans-complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the lipid rearrangements of fusion.

Original languageEnglish (US)
Pages (from-to)707-711
Number of pages5
JournalMolecular Biology of the Cell
Volume28
Issue number6
DOIs
StatePublished - Mar 15 2017

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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