A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory

Mu Zhou, Zhihui Liu, Maxwell D. Melin, Yi Han Ng, Wei Xu, Thomas C. Südhof

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The formation and retrieval of conditioned fear memories critically depend on the amygdala. Here we identify an inhibitory projection from somatostatin-positive neurons in the central amygdala to parvalbumin-positive neurons in the zona incerta that is required for both recent and remote fear memories. Thus, the amygdala inhibitory input to parvalbumin-positive neurons in the zona incerta, a nucleus not previously implicated in fear memory, is an essential component of the fear memory circuitry.

Original languageEnglish (US)
Pages (from-to)1515-1519
Number of pages5
JournalNature Neuroscience
Volume21
Issue number11
DOIs
StatePublished - Nov 1 2018

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Fear
Parvalbumins
Amygdala
Neurons
Long-Term Memory
Somatostatin
Central Amygdaloid Nucleus
Zona Incerta

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory. / Zhou, Mu; Liu, Zhihui; Melin, Maxwell D.; Ng, Yi Han; Xu, Wei; Südhof, Thomas C.

In: Nature Neuroscience, Vol. 21, No. 11, 01.11.2018, p. 1515-1519.

Research output: Contribution to journalArticle

Zhou, Mu ; Liu, Zhihui ; Melin, Maxwell D. ; Ng, Yi Han ; Xu, Wei ; Südhof, Thomas C. / A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory. In: Nature Neuroscience. 2018 ; Vol. 21, No. 11. pp. 1515-1519.
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