A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory

Mu Zhou, Zhihui Liu, Maxwell D. Melin, Yi Han Ng, Wei Xu, Thomas C. Südhof

Research output: Contribution to journalArticle

12 Scopus citations


The formation and retrieval of conditioned fear memories critically depend on the amygdala. Here we identify an inhibitory projection from somatostatin-positive neurons in the central amygdala to parvalbumin-positive neurons in the zona incerta that is required for both recent and remote fear memories. Thus, the amygdala inhibitory input to parvalbumin-positive neurons in the zona incerta, a nucleus not previously implicated in fear memory, is an essential component of the fear memory circuitry.

Original languageEnglish (US)
Pages (from-to)1515-1519
Number of pages5
JournalNature Neuroscience
Issue number11
StatePublished - Nov 1 2018


ASJC Scopus subject areas

  • Neuroscience(all)

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