A comparison of leukocyte function and burn mortality

E. Heck, M. A. Edgar, J. L. Hunt, C. R. Baxter

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Of the several tests which measure leukocyte bactericidal competency only one, chemotaxis, has been reported to reflect both leukocyte dysfunction and patient mortality in major thermal injury. To validate the reliability that chemotaxis reflects mortality functional chemotactic index (FCI) was measured in leukocytes from 33 patients with 30% or greater total surface area burns. Additionally, nitroblue tetrazolium (NBT) reduction and O2 consumption were compared to FCI. Significant decreases were seen in FCI values compared to normals. No differences, however, were seen in FCI values between surviving and nonsurviving patients. NBT reduction and O2 consumption also showed decreases with a significant difference between the mean decrease in surviving and nonsurviving patients. While the data show all these laboratory tests to be reflective of significant impairments in host defense, they do not appear to be reliable as predictive indices of patient survival and therefore should not be interpreted as such.

Original languageEnglish (US)
Pages (from-to)75-77
Number of pages3
JournalJournal of Trauma
Volume20
Issue number1
Publication statusPublished - 1980

    Fingerprint

ASJC Scopus subject areas

  • Surgery

Cite this

Heck, E., Edgar, M. A., Hunt, J. L., & Baxter, C. R. (1980). A comparison of leukocyte function and burn mortality. Journal of Trauma, 20(1), 75-77.