A comparison of three methods of pain control for posterior spinal fusions in adolescent idiopathic scoliosis

Todd A. Milbrandt, Manuj Singhal, Christin Minter, Anna McClung, Vishwas R. Talwalkar, Henry J. Iwinski, Janet Walker, Claire Beimesch, Christopher Montgomery, Daniel J. Sucato

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

STUDY DESIGN. Retrospective cohort study. OBJECTIVE. To compare the efficacy of patient-controlled analgesia (PCA) with morphine alone, a single preoperative intrathecal morphine injection and PCA (IT/PCA), and epidural catheter infusion without PCA (EPI) for postoperative pain control after posterior spinal fusion (PSF) and segmental spinal instrumentation (SSI) in adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA. Postoperative pain control after PSF and SSI in AIS can be managed in different ways. EPI provides for a longer period of pain relief but is reliant on the correct placement and maintenance of the catheter in the epidural space. A single preoperative intrathecal morphine injection also provides for long acting analgesia. No direct comparison of these 3 methods of postoperative pain control has been reported. METHODS. An IRB-approved retrospective chart review was performed at 2 institutions from 1997 to 2005. The medical record was reviewed to determine pain scores after surgery at multiple time periods. The 3 groups were compared using Student t test and χ and significance was defined as P < 0.05. RESULTS. There was no statistical difference in the gender, age, magnitude of curve, or number of levels fused in the IT/PCA (N = 42), PCA (N = 41), or EPI (N = 55) groups. Postoperative pain scores were lowest in the IT/PCA group in the first 8 hours (P < 0.05) but the pain scores in the EPI group were then lower through 24 hours (P < 0.05). Total morphine use (mg/kg) was lower in the IT/PCA group compared with the PCA group at 12 hours and 24 hours (P = 0.0001). Return to solid food ingestion was quickest in the EPI group (2.0 days) followed by the IT/PCA (2.6 days) and PCA alone (3.2 days) (P < 0.002). Respiratory depression and transient neurologic change occurred most frequently in the EPI group (EPI 11/55 pts vs. 1/42 IT/PCA vs. 0/41 PCA P < 0.001). Pruritis was greatest in the epidural group (11/55 P < 0.05). There were no intraoperative somatosensory-evoked potential changes or permanent neurologic injury recorded in any group. CONCLUSION. An EPI controls postoperative pain for the longest period of time and allows for a quicker return to consumption of solid foods. However, a single preoperative intrathecal morphine injection controls the pain equally for the first 24 hours with less pruritis and with less adverse events thus requiring less nursing and physician intervention after PSF and SSI in AIS. All methods were safe with no neurologic injury recorded.

Original languageEnglish (US)
Pages (from-to)1499-1503
Number of pages5
JournalSpine
Volume34
Issue number14
DOIs
StatePublished - Jun 15 2009

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Patient-Controlled Analgesia
Spinal Fusion
Scoliosis
Passive Cutaneous Anaphylaxis
Postoperative Pain
Morphine
Pain
Spinal Injections
Injections
Nervous System Trauma
Pruritus
Catheters
Epidural Space
Food
Somatosensory Evoked Potentials
Research Ethics Committees
Respiratory Insufficiency
Analgesia
Nervous System
Medical Records

Keywords

  • Adolescent idiopathic scoliosis
  • Continuous epidural infusion
  • Intrathecal morphine injection
  • Pain management
  • Patient-controlled analgesia
  • Posterior spinal fusion and instrumentation

ASJC Scopus subject areas

  • Clinical Neurology
  • Orthopedics and Sports Medicine

Cite this

Milbrandt, T. A., Singhal, M., Minter, C., McClung, A., Talwalkar, V. R., Iwinski, H. J., ... Sucato, D. J. (2009). A comparison of three methods of pain control for posterior spinal fusions in adolescent idiopathic scoliosis. Spine, 34(14), 1499-1503. https://doi.org/10.1097/BRS.0b013e3181a90ceb

A comparison of three methods of pain control for posterior spinal fusions in adolescent idiopathic scoliosis. / Milbrandt, Todd A.; Singhal, Manuj; Minter, Christin; McClung, Anna; Talwalkar, Vishwas R.; Iwinski, Henry J.; Walker, Janet; Beimesch, Claire; Montgomery, Christopher; Sucato, Daniel J.

In: Spine, Vol. 34, No. 14, 15.06.2009, p. 1499-1503.

Research output: Contribution to journalArticle

Milbrandt, TA, Singhal, M, Minter, C, McClung, A, Talwalkar, VR, Iwinski, HJ, Walker, J, Beimesch, C, Montgomery, C & Sucato, DJ 2009, 'A comparison of three methods of pain control for posterior spinal fusions in adolescent idiopathic scoliosis', Spine, vol. 34, no. 14, pp. 1499-1503. https://doi.org/10.1097/BRS.0b013e3181a90ceb
Milbrandt TA, Singhal M, Minter C, McClung A, Talwalkar VR, Iwinski HJ et al. A comparison of three methods of pain control for posterior spinal fusions in adolescent idiopathic scoliosis. Spine. 2009 Jun 15;34(14):1499-1503. https://doi.org/10.1097/BRS.0b013e3181a90ceb
Milbrandt, Todd A. ; Singhal, Manuj ; Minter, Christin ; McClung, Anna ; Talwalkar, Vishwas R. ; Iwinski, Henry J. ; Walker, Janet ; Beimesch, Claire ; Montgomery, Christopher ; Sucato, Daniel J. / A comparison of three methods of pain control for posterior spinal fusions in adolescent idiopathic scoliosis. In: Spine. 2009 ; Vol. 34, No. 14. pp. 1499-1503.
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T1 - A comparison of three methods of pain control for posterior spinal fusions in adolescent idiopathic scoliosis

AU - Milbrandt, Todd A.

AU - Singhal, Manuj

AU - Minter, Christin

AU - McClung, Anna

AU - Talwalkar, Vishwas R.

AU - Iwinski, Henry J.

AU - Walker, Janet

AU - Beimesch, Claire

AU - Montgomery, Christopher

AU - Sucato, Daniel J.

PY - 2009/6/15

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N2 - STUDY DESIGN. Retrospective cohort study. OBJECTIVE. To compare the efficacy of patient-controlled analgesia (PCA) with morphine alone, a single preoperative intrathecal morphine injection and PCA (IT/PCA), and epidural catheter infusion without PCA (EPI) for postoperative pain control after posterior spinal fusion (PSF) and segmental spinal instrumentation (SSI) in adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA. Postoperative pain control after PSF and SSI in AIS can be managed in different ways. EPI provides for a longer period of pain relief but is reliant on the correct placement and maintenance of the catheter in the epidural space. A single preoperative intrathecal morphine injection also provides for long acting analgesia. No direct comparison of these 3 methods of postoperative pain control has been reported. METHODS. An IRB-approved retrospective chart review was performed at 2 institutions from 1997 to 2005. The medical record was reviewed to determine pain scores after surgery at multiple time periods. The 3 groups were compared using Student t test and χ and significance was defined as P < 0.05. RESULTS. There was no statistical difference in the gender, age, magnitude of curve, or number of levels fused in the IT/PCA (N = 42), PCA (N = 41), or EPI (N = 55) groups. Postoperative pain scores were lowest in the IT/PCA group in the first 8 hours (P < 0.05) but the pain scores in the EPI group were then lower through 24 hours (P < 0.05). Total morphine use (mg/kg) was lower in the IT/PCA group compared with the PCA group at 12 hours and 24 hours (P = 0.0001). Return to solid food ingestion was quickest in the EPI group (2.0 days) followed by the IT/PCA (2.6 days) and PCA alone (3.2 days) (P < 0.002). Respiratory depression and transient neurologic change occurred most frequently in the EPI group (EPI 11/55 pts vs. 1/42 IT/PCA vs. 0/41 PCA P < 0.001). Pruritis was greatest in the epidural group (11/55 P < 0.05). There were no intraoperative somatosensory-evoked potential changes or permanent neurologic injury recorded in any group. CONCLUSION. An EPI controls postoperative pain for the longest period of time and allows for a quicker return to consumption of solid foods. However, a single preoperative intrathecal morphine injection controls the pain equally for the first 24 hours with less pruritis and with less adverse events thus requiring less nursing and physician intervention after PSF and SSI in AIS. All methods were safe with no neurologic injury recorded.

AB - STUDY DESIGN. Retrospective cohort study. OBJECTIVE. To compare the efficacy of patient-controlled analgesia (PCA) with morphine alone, a single preoperative intrathecal morphine injection and PCA (IT/PCA), and epidural catheter infusion without PCA (EPI) for postoperative pain control after posterior spinal fusion (PSF) and segmental spinal instrumentation (SSI) in adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA. Postoperative pain control after PSF and SSI in AIS can be managed in different ways. EPI provides for a longer period of pain relief but is reliant on the correct placement and maintenance of the catheter in the epidural space. A single preoperative intrathecal morphine injection also provides for long acting analgesia. No direct comparison of these 3 methods of postoperative pain control has been reported. METHODS. An IRB-approved retrospective chart review was performed at 2 institutions from 1997 to 2005. The medical record was reviewed to determine pain scores after surgery at multiple time periods. The 3 groups were compared using Student t test and χ and significance was defined as P < 0.05. RESULTS. There was no statistical difference in the gender, age, magnitude of curve, or number of levels fused in the IT/PCA (N = 42), PCA (N = 41), or EPI (N = 55) groups. Postoperative pain scores were lowest in the IT/PCA group in the first 8 hours (P < 0.05) but the pain scores in the EPI group were then lower through 24 hours (P < 0.05). Total morphine use (mg/kg) was lower in the IT/PCA group compared with the PCA group at 12 hours and 24 hours (P = 0.0001). Return to solid food ingestion was quickest in the EPI group (2.0 days) followed by the IT/PCA (2.6 days) and PCA alone (3.2 days) (P < 0.002). Respiratory depression and transient neurologic change occurred most frequently in the EPI group (EPI 11/55 pts vs. 1/42 IT/PCA vs. 0/41 PCA P < 0.001). Pruritis was greatest in the epidural group (11/55 P < 0.05). There were no intraoperative somatosensory-evoked potential changes or permanent neurologic injury recorded in any group. CONCLUSION. An EPI controls postoperative pain for the longest period of time and allows for a quicker return to consumption of solid foods. However, a single preoperative intrathecal morphine injection controls the pain equally for the first 24 hours with less pruritis and with less adverse events thus requiring less nursing and physician intervention after PSF and SSI in AIS. All methods were safe with no neurologic injury recorded.

KW - Adolescent idiopathic scoliosis

KW - Continuous epidural infusion

KW - Intrathecal morphine injection

KW - Pain management

KW - Patient-controlled analgesia

KW - Posterior spinal fusion and instrumentation

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