A composite likelihood method for bivariate meta-analysis in diagnostic systematic reviews

Yong Chen, Yulun Liu, Jing Ning, Lei Nie, Hongjian Zhu, Haitao Chu

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Diagnostic systematic review is a vital step in the evaluation of diagnostic technologies. In many applications, it involves pooling pairs of sensitivity and specificity of a dichotomized diagnostic test from multiple studies. We propose a composite likelihood (CL) method for bivariate meta-analysis in diagnostic systematic reviews. This method provides an alternative way to make inference on diagnostic measures such as sensitivity, specificity, likelihood ratios, and diagnostic odds ratio. Its main advantages over the standard likelihood method are the avoidance of the nonconvergence problem, which is nontrivial when the number of studies is relatively small, the computational simplicity, and some robustness to model misspecifications. Simulation studies show that the CL method maintains high relative efficiency compared to that of the standard likelihood method. We illustrate our method in a diagnostic review of the performance of contemporary diagnostic imaging technologies for detecting metastases in patients with melanoma.

Original languageEnglish (US)
Pages (from-to)914-930
Number of pages17
JournalStatistical Methods in Medical Research
Volume26
Issue number2
DOIs
StatePublished - Apr 1 2017
Externally publishedYes

Keywords

  • Bivariate generalized linear mixed effects model
  • composite likelihood
  • diagnostic accuracy
  • diagnostic review
  • meta-analysis

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability
  • Health Information Management

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