A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases

Anna K. Lee, Patrick Ryan Potts

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Melanoma antigen (MAGE) genes are conserved in all eukaryotes and encode for proteins sharing a common MAGE homology domain. Although only a single MAGE gene exists in lower eukaryotes, the MAGE family rapidly expanded in eutherians and consists of more than 50 highly conserved genes in humans. A subset of MAGEs initially garnered interest as cancer biomarkers and immunotherapeutic targets due to their antigenic properties and unique expression pattern that is primary restricted to germ cells and aberrantly reactivated in various cancers. However, further investigation revealed that MAGEs not only drive tumorigenesis but also regulate pathways essential for diverse cellular and developmental processes. Therefore, MAGEs are implicated in a broad range of diseases including neurodevelopmental, renal, and lung disorders, and cancer. Recent biochemical and biophysical studies indicate that MAGEs assemble with E3 RING ubiquitin ligases to form MAGE-RING ligases (MRLs) and act as regulators of ubiquitination by modulating ligase activity, substrate specification, and subcellular localization. Here, we present a comprehensive guide to MAGEs highlighting the molecular mechanisms of MRLs and their physiological roles in germ cell and neural development, oncogenic functions in cancer, and potential as therapeutic targets in disease.

Original languageEnglish (US)
Pages (from-to)1114-1142
Number of pages29
JournalJournal of Molecular Biology
Volume429
Issue number8
DOIs
StatePublished - Apr 21 2017

Fingerprint

Melanoma-Specific Antigens
Ligases
Ubiquitin
Eukaryota
Germ Cells
Genes
Ubiquitin-Protein Ligases
Ubiquitination
Tumor Biomarkers
Lung Neoplasms
Neoplasms
Carcinogenesis
Kidney
Proteins

Keywords

  • cancer-testis antigens
  • E3 ligases
  • MAGE
  • ubiquitin

ASJC Scopus subject areas

  • Molecular Biology

Cite this

A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases. / Lee, Anna K.; Potts, Patrick Ryan.

In: Journal of Molecular Biology, Vol. 429, No. 8, 21.04.2017, p. 1114-1142.

Research output: Contribution to journalReview article

Lee, Anna K. ; Potts, Patrick Ryan. / A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases. In: Journal of Molecular Biology. 2017 ; Vol. 429, No. 8. pp. 1114-1142.
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