A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M

Zhigang Weng, Anne Catherine Fluckiger, Sazuku Nisitani, Matthew I. Wahl, Lu Q. Le, Charity A. Hunter, Anthony A. Fernal, Michelle M. Le Beau, Owen N. Witte

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113 Scopus citations

Abstract

Cell cycle progression is monitored by highly coordinated checkpoint machinery, which is activated to induce cell cycle arrest until defects like DNA damage are corrected. We have isolated an anti-proliferative cell cycle regulator named G2A (for G2 accumulation), which is predominantly expressed in immature T and B lymphocyte progenitors and is a member of the seven membrane-spanning G protein-coupled receptor family. G2A overexpression attenuates the transformation potential of BCR-ABL and other oncogenes, and leads to accumulation of cells at G2/M independently of p53 and c-Abl. G2A can be induced in lymphocytes and to a lesser extent in nonlymphocyte cell lines or tissues by multiple stimuli including different classes of DNA- damaging agents and serves as a response to damage and cellular stimulation which functions to slow cell cycle progression.

Original languageEnglish (US)
Pages (from-to)12334-12339
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number21
DOIs
StatePublished - Oct 13 1998

ASJC Scopus subject areas

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    Weng, Z., Fluckiger, A. C., Nisitani, S., Wahl, M. I., Le, L. Q., Hunter, C. A., Fernal, A. A., Le Beau, M. M., & Witte, O. N. (1998). A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proceedings of the National Academy of Sciences of the United States of America, 95(21), 12334-12339. https://doi.org/10.1073/pnas.95.21.12334