A dose-dependent relationship between mercury exposure from dental amalgams and urinary mercury levels

A further assessment of the Casa Pia Children's Dental Amalgam Trial

D. A. Geier, T. Carmody, J. K. Kern, P. G. King, M. R. Geier

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Dental amalgams are a commonly used dental restorative material, and amalgams are about 50% mercury (Hg). In our study, urinary Hg levels was examined in children of age 8-18 years, with and without dental amalgam fillings, from a completed clinical trial (parent study) that was designed to evaluate the potential health consequences of prolonged exposure to Hg from dental amalgam fillings. Our study was designed to determine whether there was a significant dose-dependent correlation between increasing Hg exposure from dental amalgams and urinary Hg levels. Hg exposure depends on the size and number of teeth with dental amalgams. Overall, consistent with the results observed in the parent study, there was a statistically significant dose-dependent correlation between cumulative exposure to Hg from dental amalgams and urinary Hg levels, after covariate adjustment. Further, it was observed that urinary Hg levels increased by 18% to 52% among 8 to 18 year old individuals, respectively, with an average exposure to amalgams, in comparison to study subjects with no exposure to amalgams. The results of our study suggest that dental amalgams contribute to ongoing Hg exposure in a dose-dependent fashion.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalHuman and Experimental Toxicology
Volume31
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Dental Amalgam
Mercury
Mercury amalgams
Dental amalgams
Dental materials
Dental Materials
Health
Tooth
Clinical Trials

Keywords

  • dose dependent
  • mercury
  • toxicokinetics
  • urine

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

A dose-dependent relationship between mercury exposure from dental amalgams and urinary mercury levels : A further assessment of the Casa Pia Children's Dental Amalgam Trial. / Geier, D. A.; Carmody, T.; Kern, J. K.; King, P. G.; Geier, M. R.

In: Human and Experimental Toxicology, Vol. 31, No. 1, 01.2012, p. 11-17.

Research output: Contribution to journalArticle

@article{9b1f8311f7454cb48ea1e616fabdf01b,
title = "A dose-dependent relationship between mercury exposure from dental amalgams and urinary mercury levels: A further assessment of the Casa Pia Children's Dental Amalgam Trial",
abstract = "Dental amalgams are a commonly used dental restorative material, and amalgams are about 50{\%} mercury (Hg). In our study, urinary Hg levels was examined in children of age 8-18 years, with and without dental amalgam fillings, from a completed clinical trial (parent study) that was designed to evaluate the potential health consequences of prolonged exposure to Hg from dental amalgam fillings. Our study was designed to determine whether there was a significant dose-dependent correlation between increasing Hg exposure from dental amalgams and urinary Hg levels. Hg exposure depends on the size and number of teeth with dental amalgams. Overall, consistent with the results observed in the parent study, there was a statistically significant dose-dependent correlation between cumulative exposure to Hg from dental amalgams and urinary Hg levels, after covariate adjustment. Further, it was observed that urinary Hg levels increased by 18{\%} to 52{\%} among 8 to 18 year old individuals, respectively, with an average exposure to amalgams, in comparison to study subjects with no exposure to amalgams. The results of our study suggest that dental amalgams contribute to ongoing Hg exposure in a dose-dependent fashion.",
keywords = "dose dependent, mercury, toxicokinetics, urine",
author = "Geier, {D. A.} and T. Carmody and Kern, {J. K.} and King, {P. G.} and Geier, {M. R.}",
year = "2012",
month = "1",
doi = "10.1177/0960327111417264",
language = "English (US)",
volume = "31",
pages = "11--17",
journal = "Human and Experimental Toxicology",
issn = "0960-3271",
publisher = "SAGE Publications Inc.",
number = "1",

}

TY - JOUR

T1 - A dose-dependent relationship between mercury exposure from dental amalgams and urinary mercury levels

T2 - A further assessment of the Casa Pia Children's Dental Amalgam Trial

AU - Geier, D. A.

AU - Carmody, T.

AU - Kern, J. K.

AU - King, P. G.

AU - Geier, M. R.

PY - 2012/1

Y1 - 2012/1

N2 - Dental amalgams are a commonly used dental restorative material, and amalgams are about 50% mercury (Hg). In our study, urinary Hg levels was examined in children of age 8-18 years, with and without dental amalgam fillings, from a completed clinical trial (parent study) that was designed to evaluate the potential health consequences of prolonged exposure to Hg from dental amalgam fillings. Our study was designed to determine whether there was a significant dose-dependent correlation between increasing Hg exposure from dental amalgams and urinary Hg levels. Hg exposure depends on the size and number of teeth with dental amalgams. Overall, consistent with the results observed in the parent study, there was a statistically significant dose-dependent correlation between cumulative exposure to Hg from dental amalgams and urinary Hg levels, after covariate adjustment. Further, it was observed that urinary Hg levels increased by 18% to 52% among 8 to 18 year old individuals, respectively, with an average exposure to amalgams, in comparison to study subjects with no exposure to amalgams. The results of our study suggest that dental amalgams contribute to ongoing Hg exposure in a dose-dependent fashion.

AB - Dental amalgams are a commonly used dental restorative material, and amalgams are about 50% mercury (Hg). In our study, urinary Hg levels was examined in children of age 8-18 years, with and without dental amalgam fillings, from a completed clinical trial (parent study) that was designed to evaluate the potential health consequences of prolonged exposure to Hg from dental amalgam fillings. Our study was designed to determine whether there was a significant dose-dependent correlation between increasing Hg exposure from dental amalgams and urinary Hg levels. Hg exposure depends on the size and number of teeth with dental amalgams. Overall, consistent with the results observed in the parent study, there was a statistically significant dose-dependent correlation between cumulative exposure to Hg from dental amalgams and urinary Hg levels, after covariate adjustment. Further, it was observed that urinary Hg levels increased by 18% to 52% among 8 to 18 year old individuals, respectively, with an average exposure to amalgams, in comparison to study subjects with no exposure to amalgams. The results of our study suggest that dental amalgams contribute to ongoing Hg exposure in a dose-dependent fashion.

KW - dose dependent

KW - mercury

KW - toxicokinetics

KW - urine

UR - http://www.scopus.com/inward/record.url?scp=84856064591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856064591&partnerID=8YFLogxK

U2 - 10.1177/0960327111417264

DO - 10.1177/0960327111417264

M3 - Article

VL - 31

SP - 11

EP - 17

JO - Human and Experimental Toxicology

JF - Human and Experimental Toxicology

SN - 0960-3271

IS - 1

ER -