A Frequency Translation System for Multi-Channel, Multi-Nuclear MR Spectroscopy

Stephen E. Ogier, Matthew Wilcox, Sergey Cheshkov, Ivan E. Dimitrov, Craig R. Malloy, Mary P. McDougall, Steven M. Wright

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: Most MRI scanners are equipped to receive signals from 1H array coils but few support multi-channel reception for other nuclei. Using receive arrays can provide significant SNR benefits, usually exploited to enable accelerated imaging, but the extension of these arrays to non-1H nuclei has received less attention because of the relative lack of broadband array receivers. Non-1H nuclei often have low sensitivity and stand to benefit greatly from the increase in SNR that arrays can provide. This paper presents a cost-effective approach for adapting standard 1H multi-channel array receivers for use with other nuclei-in this case, 13C. Methods: A frequency translation system has been developed that uses active mixers residing at the magnet bore to convert the received signal from a non-1H array to the 1H frequency for reception by the host system receiver. Results: This system has been demonstrated at 4.7T and 7T while preserving SNR and isolation. 1H decoupling, particularly important for 13C detection, can be straightforwardly accommodated. Conclusion: Frequency translation can convert 1H-only multi-channel receivers for use with other nuclei while maintaining SNR and channel isolation while still enabling 1H decoupling. Significance: This work allows existing multi-channel MRI receivers to be adapted to receive signals from nuclei other than 1H, allowing for the use of receive arrays for in vivo multi-nuclear NMR.

Original languageEnglish (US)
Article number9099906
Pages (from-to)109-118
Number of pages10
JournalIEEE Transactions on Biomedical Engineering
Volume68
Issue number1
DOIs
StatePublished - Jan 2021
Externally publishedYes

Keywords

  • 13 C
  • 7T
  • MRI receivers
  • decoupling
  • high field MRI
  • in vivo NMR
  • spectroscopy

ASJC Scopus subject areas

  • Biomedical Engineering

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