A general chemical shift decomposition method for hyperpolarized 13C metabolite magnetic resonance imaging

Jian Xiong Wang, Matthew E. Merritt, Dean Sherry, Craig R. Malloy

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Metabolic imaging with hyperpolarized carbon-13 allows sequential steps of metabolism to be detected in vivo. Potential applications in cancer, brain, muscular, myocardial, and hepatic metabolism suggest that clinical applications could be readily developed. A primary concern in imaging hyperpolarized nuclei is the irreversible decay of the enhanced magnetization back to thermal equilibrium. Multiple methods for rapid imaging of hyperpolarized substrates and their products have been proposed with a multi-point Dixon method distinguishing itself as a robust protocol for imaging [1-13C]pyruvate. We describe here a generalized chemical shift decomposition method that incorporates a single-shot spiral imaging sequence plus a spectroscopic sequence to retain as much spin polarization as possible while allowing detection of metabolites that have a wide range of chemical shift values. The new method is demonstrated for hyperpolarized [1-13C]pyruvate, [1-13C]acetoacetate, and [2-13C]dihydroxyacetone.

Original languageEnglish (US)
Pages (from-to)665-673
Number of pages9
JournalMagnetic Resonance in Chemistry
DOIs
StatePublished - Aug 1 2016

Keywords

  • C MR
  • chemical shift
  • decomposition
  • hyperpolarized
  • metabolite imaging

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)

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