A full-length cDNA encoding a human homolog of the approx. 110-kDa subunit (elongin A; El A) of the RNA polymerase II transcription factor, elongin, was isolated and sequenced. Comparison of the open reading frames of the human El A cDNA and the previously characterized rat El A cDNA [Aso et al., Science 269 (1995)1439-1443] indicates that they are 84% conserved in nucleotide sequence and encode 84% identical proteins.
- Eukaryotic messenger RNA synthesis
- RNA chain elongation
- Transcriptional regulation
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