TY - JOUR
T1 - A lack of unique pathophysiologic background for nephrolithiasis of primary hyperparathyroidism
AU - Pak, C. Y C
AU - Nicar, M. J.
AU - Peterson, R.
AU - Zerwekh, J. E.
AU - Snyder, W.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1981/9
Y1 - 1981/9
N2 - The metabolic picture of 32 patients with surgically proven primary hyperparathyroidism presenting with renal stones was compared with that of 37 patients without stones. Between stone-forming and nonstone-forming groups, there was no significant difference in serum 1, 25-dihydroxyvitamin D [6.82 ± 2.62 vs. 6.22 ± 2.33 ng/dl (mean ± SD); P > 0.05], fractional (intestinal) calcium absorption (0.726 ± 0.141 vs. 0.690 ± 0.120), urinary clacium (299 ± 139 vs. 284 ± 144 mg/day), serum calcium, phosphorus, and parathyroid hormone, or bone density. Similarly, no differences were found between 29 patients presenting with stones alone and 9 presenting with bone disease alone with respect to the above measures. Moreover, urinary environment was typically supersaturated with respect to stoneforming salts regardless of the presence of stones. The results indicate that there is no unique pathophysiological background for the nephrolithiasis of primary hyperparathyroidism.
AB - The metabolic picture of 32 patients with surgically proven primary hyperparathyroidism presenting with renal stones was compared with that of 37 patients without stones. Between stone-forming and nonstone-forming groups, there was no significant difference in serum 1, 25-dihydroxyvitamin D [6.82 ± 2.62 vs. 6.22 ± 2.33 ng/dl (mean ± SD); P > 0.05], fractional (intestinal) calcium absorption (0.726 ± 0.141 vs. 0.690 ± 0.120), urinary clacium (299 ± 139 vs. 284 ± 144 mg/day), serum calcium, phosphorus, and parathyroid hormone, or bone density. Similarly, no differences were found between 29 patients presenting with stones alone and 9 presenting with bone disease alone with respect to the above measures. Moreover, urinary environment was typically supersaturated with respect to stoneforming salts regardless of the presence of stones. The results indicate that there is no unique pathophysiological background for the nephrolithiasis of primary hyperparathyroidism.
UR - http://www.scopus.com/inward/record.url?scp=0019721662&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019721662&partnerID=8YFLogxK
U2 - 10.1210/jcem-53-3-536
DO - 10.1210/jcem-53-3-536
M3 - Article
C2 - 7263839
AN - SCOPUS:0019721662
SN - 0021-972X
VL - 53
SP - 536
EP - 542
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 3
ER -