A lack of unique pathophysiologic background for nephrolithiasis of primary hyperparathyroidism

C. Y C Pak, M. J. Nicar, R. Peterson, J. E. Zerwekh, W. Snyder

Research output: Contribution to journalArticle

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Abstract

The metabolic picture of 32 patients with surgically proven primary hyperparathyroidism presenting with renal stones was compared with that of 37 patients without stones. Between stone-forming and nonstone-forming groups, there was no significant difference in serum 1,25-dihydroxyvitamin D [6.82 ± 2.62 vs. 6.22 ± 2.33 ng/dl (mean ± SD); P > 0.05], fractional (intestinal) calcium absorption (0.726 ± 0.141 vs. 0.690 ± 0.120), urinary calcium (299 ± 139 vs. 284 ± 144 mg/day), serum calcium, phosphorus, and parathyroid hormone, or bone density. Similarly, no differences were found between 29 patients presenting with stones alone and 9 presenting with bone disease alone with respect to the above measures. Moreover, urinary environment was typically supersaturated with respect to stone-forming salts regardless of the presence of stones. The results indicate that there is no unique pathophysiological background for the nephrolithiasis of primary hyperparathyroidism.

Original languageEnglish (US)
Pages (from-to)536-542
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume53
Issue number3
StatePublished - 1981

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Nephrolithiasis
Primary Hyperparathyroidism
Calcium
Bone
Bone Diseases
Intestinal Absorption
Parathyroid Hormone
Serum
Bone Density
Phosphorus
Salts
Kidney

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

A lack of unique pathophysiologic background for nephrolithiasis of primary hyperparathyroidism. / Pak, C. Y C; Nicar, M. J.; Peterson, R.; Zerwekh, J. E.; Snyder, W.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 53, No. 3, 1981, p. 536-542.

Research output: Contribution to journalArticle

Pak, C. Y C ; Nicar, M. J. ; Peterson, R. ; Zerwekh, J. E. ; Snyder, W. / A lack of unique pathophysiologic background for nephrolithiasis of primary hyperparathyroidism. In: Journal of Clinical Endocrinology and Metabolism. 1981 ; Vol. 53, No. 3. pp. 536-542.
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