A minimal domain responsible for Munc13 activity

Jayeeta Basu, Nan Shen, Irina Dulubova, Jun Lu, Rong Guan, Oleg Guryev, Nick V Grishin, Christian Rosenmund, Jose Rizo-Rey

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Munc13 proteins are essential in neurotransmitter release, controlling the priming of synaptic vesicles to a release-ready state. The sequences responsible for this priming activity are unknown. Here we identify a large α-helical domain of mammalian Munc13-1 that is autonomously folded and is sufficient to rescue the total arrest in neurotransmitter release observed in hippocampal neurons lacking Munc13s.

Original languageEnglish (US)
Pages (from-to)1017-1018
Number of pages2
JournalNature Structural and Molecular Biology
Volume12
Issue number11
DOIs
StatePublished - Nov 29 2005

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Neurotransmitter Agents
Synaptic Vesicles
Neurons
Proteins

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Cite this

Basu, J., Shen, N., Dulubova, I., Lu, J., Guan, R., Guryev, O., ... Rizo-Rey, J. (2005). A minimal domain responsible for Munc13 activity. Nature Structural and Molecular Biology, 12(11), 1017-1018. https://doi.org/10.1038/nm1005-1017a

A minimal domain responsible for Munc13 activity. / Basu, Jayeeta; Shen, Nan; Dulubova, Irina; Lu, Jun; Guan, Rong; Guryev, Oleg; Grishin, Nick V; Rosenmund, Christian; Rizo-Rey, Jose.

In: Nature Structural and Molecular Biology, Vol. 12, No. 11, 29.11.2005, p. 1017-1018.

Research output: Contribution to journalArticle

Basu, J, Shen, N, Dulubova, I, Lu, J, Guan, R, Guryev, O, Grishin, NV, Rosenmund, C & Rizo-Rey, J 2005, 'A minimal domain responsible for Munc13 activity', Nature Structural and Molecular Biology, vol. 12, no. 11, pp. 1017-1018. https://doi.org/10.1038/nm1005-1017a
Basu J, Shen N, Dulubova I, Lu J, Guan R, Guryev O et al. A minimal domain responsible for Munc13 activity. Nature Structural and Molecular Biology. 2005 Nov 29;12(11):1017-1018. https://doi.org/10.1038/nm1005-1017a
Basu, Jayeeta ; Shen, Nan ; Dulubova, Irina ; Lu, Jun ; Guan, Rong ; Guryev, Oleg ; Grishin, Nick V ; Rosenmund, Christian ; Rizo-Rey, Jose. / A minimal domain responsible for Munc13 activity. In: Nature Structural and Molecular Biology. 2005 ; Vol. 12, No. 11. pp. 1017-1018.
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