A minimal domain responsible for Munc13 activity

Jayeeta Basu, Nan Shen, Irina Dulubova, Jun Lu, Rong Guan, Oleg Guryev, Nick V Grishin, Christian Rosenmund, Jose Rizo-Rey

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

Munc13 proteins are essential in neurotransmitter release, controlling the priming of synaptic vesicles to a release-ready state. The sequences responsible for this priming activity are unknown. Here we identify a large α-helical domain of mammalian Munc13-1 that is autonomously folded and is sufficient to rescue the total arrest in neurotransmitter release observed in hippocampal neurons lacking Munc13s.

Original languageEnglish (US)
Pages (from-to)1017-1018
Number of pages2
JournalNature Structural and Molecular Biology
Volume12
Issue number11
DOIs
StatePublished - Nov 29 2005

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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