@article{ee9d68a0c61b4ba897e330887e7f6896,
title = "A minimal domain responsible for Munc13 activity",
abstract = "Munc13 proteins are essential in neurotransmitter release, controlling the priming of synaptic vesicles to a release-ready state. The sequences responsible for this priming activity are unknown. Here we identify a large α-helical domain of mammalian Munc13-1 that is autonomously folded and is sufficient to rescue the total arrest in neurotransmitter release observed in hippocampal neurons lacking Munc13s.",
author = "Jayeeta Basu and Nan Shen and Irina Dulubova and Jun Lu and Rong Guan and Oleg Guryev and Grishin, {Nick V} and Christian Rosenmund and Jose Rizo-Rey",
note = "Funding Information: We thank T. S{\"u}dhof for fruitful discussions, H. Deng and R. Nehring for technical support and N. Brose (Max Planck Institute for Experimental Medicine, Gottingen, Germany) for providing the Munc13-1 and Munc13-2 double-knockout mice and the pSFV1-Munc13-1WT-EGFP vector. This work was supported by a grant from the Muscular Dystrophy Association and by US National Institutes of Health grants NS37200 to J.R. and NS51262 to C.R.",
year = "2005",
month = nov,
day = "29",
doi = "10.1038/nsmb1001",
language = "English (US)",
volume = "12",
pages = "1017--1018",
journal = "Nature Structural and Molecular Biology",
issn = "1545-9993",
publisher = "Nature Publishing Group",
number = "11",
}