A neonatal blueprint for cardiac regeneration

Enzo R. Porrello, Eric N. Olson

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Adult mammals undergo minimal regeneration following cardiac injury, which severely compromises cardiac function and contributes to the ongoing burden of heart failure. In contrast, the mammalian heart retains a transient capacity for cardiac regeneration during fetal and early neonatal life. Recent studies have established the importance of several evolutionarily conserved mechanisms for heart regeneration in lower vertebrates and neonatal mammals including induction of cardiomyocyte proliferation, epicardial cell activation, angiogenesis, extracellular matrix deposition and immune cell infiltration. In this review, we provide an up-to-date account of the molecular and cellular basis for cardiac regeneration in lower vertebrates and neonatal mammals. The historical context for these recent findings and their ramifications for the future development of cardiac regenerative therapies are also discussed.

Original languageEnglish (US)
Pages (from-to)556-570
Number of pages15
JournalStem Cell Research
Volume13
Issue number3
DOIs
StatePublished - Nov 1 2014

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Regeneration
Mammals
Vertebrates
Cardiac Myocytes
Extracellular Matrix
Heart Failure
Cell Proliferation
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Medicine(all)

Cite this

A neonatal blueprint for cardiac regeneration. / Porrello, Enzo R.; Olson, Eric N.

In: Stem Cell Research, Vol. 13, No. 3, 01.11.2014, p. 556-570.

Research output: Contribution to journalArticle

Porrello, Enzo R. ; Olson, Eric N. / A neonatal blueprint for cardiac regeneration. In: Stem Cell Research. 2014 ; Vol. 13, No. 3. pp. 556-570.
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