A network of electrically coupled interneurons drives synchronized inhibition in neocortex

Michael Beierlein, Jay R. Gibson, Barry W. Connors

Research output: Contribution to journalArticle

363 Citations (Scopus)

Abstract

The neocortex has at least two different networks of electrically coupled inhibitory interneurons: fast-spiking (FS) and low-threshold-spiking (LTS) cells. Agonists of metabotropic glutamate or acetylcholine receptors induced synchronized spiking and membrane fluctuations, with irregular or rhythmic patterns, in networks of LTS cells. LTS activity was closely correlated with inhibitory postsynaptic potentials in neighboring FS interneurons and excitatory neurons. Synchronized LTS activity required electrical synapses, but not fast chemical synapses. Tetanic stimulation of local circuitry induced effects similar to those of metabotropic agonists. We conclude that an electrically coupled network of LTS interneurons can mediate synchronized inhibition when activated by modulatory neurotransmitters.

Original languageEnglish (US)
Pages (from-to)904-910
Number of pages7
JournalNature Neuroscience
Volume3
Issue number9
DOIs
StatePublished - Sep 2000

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Neocortex
Interneurons
Electrical Synapses
Inhibitory Postsynaptic Potentials
Metabotropic Glutamate Receptors
Cholinergic Receptors
Synapses
Neurotransmitter Agents
Neurons
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A network of electrically coupled interneurons drives synchronized inhibition in neocortex. / Beierlein, Michael; Gibson, Jay R.; Connors, Barry W.

In: Nature Neuroscience, Vol. 3, No. 9, 09.2000, p. 904-910.

Research output: Contribution to journalArticle

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