A neuroendocrine study of supersensitivity in tardive dyskinesia

C. A. Tamminga, R. C. Smith, G. Pandey, L. A. Frohman, J. M. Davis

Research output: Contribution to journalArticle

50 Scopus citations


A study of the tuberoinfundibular dopamine tract was undertaken in chronic schizophrenic patients with and without tardive dyskinesia. Biochemical evidence of the purported dopamine receptor supersensitivity in tardive dyskinesia was sought by demonstrating a hyperresponse of growth hormone and prolactin to dopamine agonists. Contrary to this prediction, no endocrine supersensitivity occurred in the tardive dyskinesia patients. Rather, a significantly decreased reponse to dopaminergic stimulation was demonstrated in the total chronic schizophrenic group.

Original languageEnglish (US)
Pages (from-to)1199-1203
Number of pages5
JournalArchives of General Psychiatry
Issue number10
StatePublished - 1977


ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Tamminga, C. A., Smith, R. C., Pandey, G., Frohman, L. A., & Davis, J. M. (1977). A neuroendocrine study of supersensitivity in tardive dyskinesia. Archives of General Psychiatry, 34(10), 1199-1203.