A Neuroendocrine Study of Supersensitivity in Tardive Dyskinesia

C. A. Tamminga, R. C. Smith, G. Pandey, L. A. Frohman, J. M. Davis

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

A study of the tuberoinfundibular dopamine tract was undertaken in chronic schizophrenic patients with and without tardive dyskinesia. Biochemical evidence of the purported dopamine receptor supersensitivity in tardive dyskinesia was sought by demonstrating a hyperresponse of growth hormone and prolactin to dopamine agonists. Contrary to this prediction, no endocrine supersensitivity occurred in the tardive dyskinesia patients. Rather, a significantly decreased response to dopaminergic stimualtion was demonstrated in the total chronic schizophrenic group.

Original languageEnglish (US)
Pages (from-to)1199-1203
Number of pages5
JournalArchives of General Psychiatry
Volume34
Issue number10
DOIs
StatePublished - Oct 1977

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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