A neuroendocrine study of supersensitivity in tardive dyskinesia

C. A. Tamminga, R. C. Smith, G. Pandey, L. A. Frohman, J. M. Davis

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

A study of the tuberoinfundibular dopamine tract was undertaken in chronic schizophrenic patients with and without tardive dyskinesia. Biochemical evidence of the purported dopamine receptor supersensitivity in tardive dyskinesia was sought by demonstrating a hyperresponse of growth hormone and prolactin to dopamine agonists. Contrary to this prediction, no endocrine supersensitivity occurred in the tardive dyskinesia patients. Rather, a significantly decreased reponse to dopaminergic stimulation was demonstrated in the total chronic schizophrenic group.

Original languageEnglish (US)
Pages (from-to)1199-1203
Number of pages5
JournalArchives of General Psychiatry
Volume34
Issue number10
StatePublished - 1977

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Dopamine Agonists
Dopamine Receptors
Prolactin
Growth Hormone
Dopamine
Tardive Dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Tamminga, C. A., Smith, R. C., Pandey, G., Frohman, L. A., & Davis, J. M. (1977). A neuroendocrine study of supersensitivity in tardive dyskinesia. Archives of General Psychiatry, 34(10), 1199-1203.

A neuroendocrine study of supersensitivity in tardive dyskinesia. / Tamminga, C. A.; Smith, R. C.; Pandey, G.; Frohman, L. A.; Davis, J. M.

In: Archives of General Psychiatry, Vol. 34, No. 10, 1977, p. 1199-1203.

Research output: Contribution to journalArticle

Tamminga, CA, Smith, RC, Pandey, G, Frohman, LA & Davis, JM 1977, 'A neuroendocrine study of supersensitivity in tardive dyskinesia', Archives of General Psychiatry, vol. 34, no. 10, pp. 1199-1203.
Tamminga CA, Smith RC, Pandey G, Frohman LA, Davis JM. A neuroendocrine study of supersensitivity in tardive dyskinesia. Archives of General Psychiatry. 1977;34(10):1199-1203.
Tamminga, C. A. ; Smith, R. C. ; Pandey, G. ; Frohman, L. A. ; Davis, J. M. / A neuroendocrine study of supersensitivity in tardive dyskinesia. In: Archives of General Psychiatry. 1977 ; Vol. 34, No. 10. pp. 1199-1203.
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