A Neuroendocrine Study of Supersensitivity in Tardive Dyskinesia

C. A. Tamminga; R. C. Smith; G. Pandey; L. A. Frohman; J. M. Davis

doi:10.1001/archpsyc.1977.01770220081009

A Neuroendocrine Study of Supersensitivity in Tardive Dyskinesia

C. A. Tamminga, R. C. Smith, G. Pandey, L. A. Frohman, J. M. Davis

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Abstract

A study of the tuberoinfundibular dopamine tract was undertaken in chronic schizophrenic patients with and without tardive dyskinesia. Biochemical evidence of the purported dopamine receptor supersensitivity in tardive dyskinesia was sought by demonstrating a hyperresponse of growth hormone and prolactin to dopamine agonists. Contrary to this prediction, no endocrine supersensitivity occurred in the tardive dyskinesia patients. Rather, a significantly decreased response to dopaminergic stimualtion was demonstrated in the total chronic schizophrenic group.

Original language	English (US)
Pages (from-to)	1199-1203
Number of pages	5
Journal	Archives of General Psychiatry
Volume	34
Issue number	10
DOIs	https://doi.org/10.1001/archpsyc.1977.01770220081009
State	Published - Oct 1977

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Psychiatry and Mental health

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A Neuroendocrine Study of Supersensitivity in Tardive Dyskinesia

Abstract

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