A new peptide isolated from a marine derived Streptomyces bacillaris

Youcai Hu; John B. MacMillan

doi:10.1177/1934578x1200700224

A new peptide isolated from a marine derived Streptomyces bacillaris

Youcai Hu, John B. MacMillan

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A new peptide, L-O-Lac-L-Val-D-O-Hiv-D-Val (1), consisting of D-valine, L-valine, L-lactic acid, and 3-D-hydroxyisovaleric acid, was isolated from the culture of the marine sediment derived Streptomyces bacillaris. The planar structure of compound 1 was assigned by 1D, 2D NMR and mass spectroscopic analyses. Following acid and base hydrolysis, the absolute configuration of the valine residues in 1 were determined by application of the advanced Marfey's method and the absolute configurations of hydroxy acids units were determined by a HPLC method based on Mosher's reagents.

Original language	English (US)
Pages (from-to)	211-214
Number of pages	4
Journal	Natural Product Communications
Volume	7
Issue number	2
DOIs	https://doi.org/10.1177/1934578x1200700224
State	Published - Feb 2012

Keywords

3-D-hydroxyisovaleric acid
D-valine
L-lactic acid
L-valine
Marfey's method
Mosher's reagents
Peptide
Streptomyces

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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10.1177/1934578x1200700224

Cite this

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abstract = "A new peptide, L-O-Lac-L-Val-D-O-Hiv-D-Val (1), consisting of D-valine, L-valine, L-lactic acid, and 3-D-hydroxyisovaleric acid, was isolated from the culture of the marine sediment derived Streptomyces bacillaris. The planar structure of compound 1 was assigned by 1D, 2D NMR and mass spectroscopic analyses. Following acid and base hydrolysis, the absolute configuration of the valine residues in 1 were determined by application of the advanced Marfey's method and the absolute configurations of hydroxy acids units were determined by a HPLC method based on Mosher's reagents.",

keywords = "3-D-hydroxyisovaleric acid, D-valine, L-lactic acid, L-valine, Marfey's method, Mosher's reagents, Peptide, Streptomyces",

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AB - A new peptide, L-O-Lac-L-Val-D-O-Hiv-D-Val (1), consisting of D-valine, L-valine, L-lactic acid, and 3-D-hydroxyisovaleric acid, was isolated from the culture of the marine sediment derived Streptomyces bacillaris. The planar structure of compound 1 was assigned by 1D, 2D NMR and mass spectroscopic analyses. Following acid and base hydrolysis, the absolute configuration of the valine residues in 1 were determined by application of the advanced Marfey's method and the absolute configurations of hydroxy acids units were determined by a HPLC method based on Mosher's reagents.

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KW - D-valine

KW - L-lactic acid

KW - L-valine

KW - Marfey's method

KW - Mosher's reagents

KW - Peptide

KW - Streptomyces

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A new peptide isolated from a marine derived Streptomyces bacillaris

Abstract

Keywords

ASJC Scopus subject areas

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