A new peptide isolated from a marine derived Streptomyces bacillaris

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A new peptide, L-O-Lac-L-Val-D-O-Hiv-D-Val (1), consisting of D-valine, L-valine, L-lactic acid, and 3-D-hydroxyisovaleric acid, was isolated from the culture of the marine sediment derived Streptomyces bacillaris. The planar structure of compound 1 was assigned by 1D, 2D NMR and mass spectroscopic analyses. Following acid and base hydrolysis, the absolute configuration of the valine residues in 1 were determined by application of the advanced Marfey's method and the absolute configurations of hydroxy acids units were determined by a HPLC method based on Mosher's reagents.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalNatural Product Communications
Volume7
Issue number2
DOIs
StatePublished - 2012

Keywords

  • 3-D-hydroxyisovaleric acid
  • D-valine
  • L-lactic acid
  • L-valine
  • Marfey's method
  • Mosher's reagents
  • Peptide
  • Streptomyces

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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