A new peptide isolated from a marine derived Streptomyces bacillaris

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A new peptide, L-O-Lac-L-Val-D-O-Hiv-D-Val (1), consisting of D-valine, L-valine, L-lactic acid, and 3-D-hydroxyisovaleric acid, was isolated from the culture of the marine sediment derived Streptomyces bacillaris. The planar structure of compound 1 was assigned by 1D, 2D NMR and mass spectroscopic analyses. Following acid and base hydrolysis, the absolute configuration of the valine residues in 1 were determined by application of the advanced Marfey's method and the absolute configurations of hydroxy acids units were determined by a HPLC method based on Mosher's reagents.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalNatural Product Communications
Volume7
Issue number2
StatePublished - 2012

Fingerprint

Streptomyces bacillaris
Valine
Streptomyces
valine
peptides
Peptides
acids
Geologic Sediments
Hydroxy Acids
marine sediments
lactic acid
Lactic Acid
Hydrolysis
hydrolysis
High Pressure Liquid Chromatography
Acids
methodology

Keywords

  • 3-D-hydroxyisovaleric acid
  • D-valine
  • L-lactic acid
  • L-valine
  • Marfey's method
  • Mosher's reagents
  • Peptide
  • Streptomyces

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Complementary and alternative medicine
  • Plant Science

Cite this

A new peptide isolated from a marine derived Streptomyces bacillaris. / Hu, Youcai; MacMillan, John B.

In: Natural Product Communications, Vol. 7, No. 2, 2012, p. 211-214.

Research output: Contribution to journalArticle

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