A new transgenic mouse model of chronic hyperglycemia

Erik M. Schaefer, Valérie Viard, Joëlle Morin, Pascal Ferré, Luc Pénicaud, Purita Ramos, Shanna D. Maika, Leland Ellis, Robert E Hammer

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Expression under the control of the mouse transferrin promoter of a transgene encoding a soluble secreted derivative of the ectodomain of the human insulin receptor in transgenic mice results in the accumulation of this high-affinity insulin-binding protein in the plasma. Alterations of glucose homeostasis are observed including postabsorptive hyperglycemia concomitant with increased hepatic glucose production and hyperinsulinemia. Thus, this is the first transgenic animal model of chronic hyperglycemia with alterations in glucose homeostasis that are produced without a targeted alteration of pancreatic function. These mice provide a new experimental model to follow the progression and long-term consequences of chronic hyperglycemia.

Original languageEnglish (US)
Pages (from-to)143-153
Number of pages11
JournalDiabetes
Volume43
Issue number1
StatePublished - Jan 1994

Fingerprint

Hyperglycemia
Transgenic Mice
Glucose
Homeostasis
Genetically Modified Animals
Hyperinsulinism
Transferrin
Transgenes
Carrier Proteins
Theoretical Models
Animal Models
Insulin
Liver
human INSR protein

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Schaefer, E. M., Viard, V., Morin, J., Ferré, P., Pénicaud, L., Ramos, P., ... Hammer, R. E. (1994). A new transgenic mouse model of chronic hyperglycemia. Diabetes, 43(1), 143-153.

A new transgenic mouse model of chronic hyperglycemia. / Schaefer, Erik M.; Viard, Valérie; Morin, Joëlle; Ferré, Pascal; Pénicaud, Luc; Ramos, Purita; Maika, Shanna D.; Ellis, Leland; Hammer, Robert E.

In: Diabetes, Vol. 43, No. 1, 01.1994, p. 143-153.

Research output: Contribution to journalArticle

Schaefer, EM, Viard, V, Morin, J, Ferré, P, Pénicaud, L, Ramos, P, Maika, SD, Ellis, L & Hammer, RE 1994, 'A new transgenic mouse model of chronic hyperglycemia', Diabetes, vol. 43, no. 1, pp. 143-153.
Schaefer EM, Viard V, Morin J, Ferré P, Pénicaud L, Ramos P et al. A new transgenic mouse model of chronic hyperglycemia. Diabetes. 1994 Jan;43(1):143-153.
Schaefer, Erik M. ; Viard, Valérie ; Morin, Joëlle ; Ferré, Pascal ; Pénicaud, Luc ; Ramos, Purita ; Maika, Shanna D. ; Ellis, Leland ; Hammer, Robert E. / A new transgenic mouse model of chronic hyperglycemia. In: Diabetes. 1994 ; Vol. 43, No. 1. pp. 143-153.
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