72As-labelled radiopharmaceuticals could be a valuable resource for Positron Emission Tomography (PET). In particular, the long half-life of 72As (T1/2 = 26 h) facilitates the observation of long-term physiological or metabolic processes, such as the enrichment and distribution of antibodies in tumor tissue. This work describes the primary radiochemical separation of no-carrier-added (nca) 72Se from cyclotron irradiated germanium targets and the development of a polystyrene type solid-phase extraction based 72Se/72As radionuclide generator, avoiding the addition of any selenium carrier. The irradiated germanium target is dissolved in HFconc and selenium is reduced with hydrazine dihydrochloride. The nca 72Se(0) is adsorbed on a solid-phase extraction cartridge, representing the generator column. The 72As is eluted using various aqueous solvents with 40%-60% yield and <0.1% 72Se content. To be able to study the radiopharmaceutical arsenic chemistry, subsequent chemical modification of the nca 72As eluates to nca [72As]AsI3 provides a versatile radioarsenic labelling synthon.
- Radionuclide generator
- Solid-phase extraction
ASJC Scopus subject areas
- Physical and Theoretical Chemistry