A novel strategy for surface modification of superparamagnetic iron oxide nanoparticles for lung cancer imaging

Gang Huang, Chunfu Zhang, Shunzi Li, Chalermchai Khemtong, Su Geun Yang, Ruhai Tian, John D. Minna, Kathlynn C. Brown, Jinming Gao

Research output: Contribution to journalArticle

72 Scopus citations


Superparamagnetic iron oxide (SPIO) nanoparticles are widely used in magnetic resonance imaging (MRI) as versatile ultra-sensitive nanoprobes for cellular and molecular imaging of cancer. In this study, we report a one-step procedure for the surface functionalization of SPIO nanoparticles with a lung cancer-targeting peptide. The hydrophobic surfactants on the as-synthesized SPIO are displaced by the peptide containing a poly(ethylene glycol)-tethered cysteine residue through ligand exchange. The resulting SPIO particles are biocompatible and demonstrate high T2 relaxivity. The nanoprobes are specific in targeting αvβ6-expressing lung cancer cells as demonstrated by MR imaging and Prussian blue staining. This facile surface chemistry and the functional design of the proposed SPIO system may provide a powerful nanoplatform for the molecular diagnosis of lung cancer.

Original languageEnglish (US)
Pages (from-to)6367-6372
Number of pages6
JournalJournal of Materials Chemistry
Issue number35
StatePublished - Sep 1 2009


ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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