A pilot study of cerebrovascular reactivity autoregulation after pediatric cardiac arrest

Jennifer K. Lee, Ken M. Brady, Shang En Chung, Jacky M. Jennings, Emmett E. Whitaker, Devon Aganga, Ronald B. Easley, Kerry Heitmiller, Jessica L. Jamrogowicz, Abby C. Larson, Jeong Hoo Lee, Lori C. Jordan, Charles W. Hogue, Christoph U. Lehmann, Mela M. Bembea, Elizabeth A. Hunt, Raymond C. Koehler, Donald H. Shaffner

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Aim: Improved survival after cardiac arrest has placed greater emphasis on neurologic resuscitation. The purpose of this pilot study was to evaluate the relationship between cerebrovascular autoregulation and neurologic outcomes after pediatric cardiac arrest. Methods: Children resuscitated from cardiac arrest had autoregulation monitoring during the first 72h after return of circulation with an index derived from near-infrared spectroscopy in a pilot study. The range of mean arterial blood pressure (MAP) with optimal vasoreactivity (MAPOPT) was identified. The area under the curve (AUC) of the time spent with MAP below MAPOPT and MAP deviation below MAPOPT was calculated. Neurologic outcome measures included placement of a new tracheostomy or gastrostomy, death from a primary neurologic etiology (brain death or withdrawal of support for neurologic futility), and change in the Pediatric Cerebral Performance Category score (δPCPC). Results: Thirty-six children were monitored. Among children who did not require extracorporeal membrane oxygenation (ECMO), children who received a tracheostomy/gastrostomy had greater AUC during the second 24h after resuscitation than those who did not (P=0.04; n=19). Children without ECMO who died from a neurologic etiology had greater AUC during the first 48h than did those who lived or died from cardiovascular failure (P=0.04; n=19). AUC below MAPOPT was not associated with δPCPC when children with or without ECMO were analyzed separately. Conclusions: Deviation from the blood pressure with optimal autoregulatory vasoreactivity may predict poor neurologic outcomes after pediatric cardiac arrest. This experimental autoregulation monitoring technique may help individualize blood pressure management goals after resuscitation.

Original languageEnglish (US)
Pages (from-to)1387-1393
Number of pages7
JournalResuscitation
Volume85
Issue number10
DOIs
StatePublished - Oct 1 2014

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Keywords

  • Blood pressure
  • Brain injuries
  • Cerebrovascular circulation
  • Heart arrest
  • Pediatrics

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

Cite this

Lee, J. K., Brady, K. M., Chung, S. E., Jennings, J. M., Whitaker, E. E., Aganga, D., Easley, R. B., Heitmiller, K., Jamrogowicz, J. L., Larson, A. C., Lee, J. H., Jordan, L. C., Hogue, C. W., Lehmann, C. U., Bembea, M. M., Hunt, E. A., Koehler, R. C., & Shaffner, D. H. (2014). A pilot study of cerebrovascular reactivity autoregulation after pediatric cardiac arrest. Resuscitation, 85(10), 1387-1393. https://doi.org/10.1016/j.resuscitation.2014.07.006