A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents

Matcheri S. Keshavan; Vaibhav A. Diwadkar; Stephen M. Spencer; Keith A. Harenski; Beatriz Luna; John A. Sweeney

doi:10.1016/S0278-5846(02)00249-X

A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents

Matcheri S. Keshavan, Vaibhav A. Diwadkar, Stephen M. Spencer, Keith A. Harenski, Beatriz Luna, John A. Sweeney

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73 Scopus citations

Abstract

Studies of high-risk offspring (HR) of schizophrenic patients have found abnormalities in attention, working memory and executive functions, suggesting impaired integrity of the prefrontal cortex and related brain regions. The authors conducted a preliminary high-field (3 T) functional magnetic resonance imaging (fMRI) study to assess performance and activation during a memory-guided saccade (MGS) task, which measures spatial working memory. HR subjects showed significant decreases in fMRI-measured activation in the dorsolateral prefrontal cortex (Brodmann's areas 8 and 9/46) and the inferior parietal cortex (Brodmann's area 40) compared to age- and sex-matched healthy controls (HC). Abnormal functional integrity of prefrontal and parietal regions of the heteromodal association cortical (HAC) regions in subjects at genetic risk for schizophrenia is consistent with findings observed in adults with the illness [Callicott et al., Cereb. Cortex 10 (2000) 1078; Manoach et al., Biol. Psychiatry 48 (2000) 99.]. These abnormalities need to be prospectively investigated in nonpsychotic individuals at risk for schizophrenia in order to determine their predictive value for eventual emergence of schizophrenia or related disorders.

Original language	English (US)
Pages (from-to)	1143-1149
Number of pages	7
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/S0278-5846(02)00249-X
State	Published - Oct 2002

Keywords

Eye movement tasks
High risk
Schizophrenia
Spatial working memory
fMRI

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/S0278-5846(02)00249-X

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title = "A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents",

abstract = "Studies of high-risk offspring (HR) of schizophrenic patients have found abnormalities in attention, working memory and executive functions, suggesting impaired integrity of the prefrontal cortex and related brain regions. The authors conducted a preliminary high-field (3 T) functional magnetic resonance imaging (fMRI) study to assess performance and activation during a memory-guided saccade (MGS) task, which measures spatial working memory. HR subjects showed significant decreases in fMRI-measured activation in the dorsolateral prefrontal cortex (Brodmann's areas 8 and 9/46) and the inferior parietal cortex (Brodmann's area 40) compared to age- and sex-matched healthy controls (HC). Abnormal functional integrity of prefrontal and parietal regions of the heteromodal association cortical (HAC) regions in subjects at genetic risk for schizophrenia is consistent with findings observed in adults with the illness [Callicott et al., Cereb. Cortex 10 (2000) 1078; Manoach et al., Biol. Psychiatry 48 (2000) 99.]. These abnormalities need to be prospectively investigated in nonpsychotic individuals at risk for schizophrenia in order to determine their predictive value for eventual emergence of schizophrenia or related disorders.",

keywords = "Eye movement tasks, High risk, Schizophrenia, Spatial working memory, fMRI",

author = "Keshavan, {Matcheri S.} and Diwadkar, {Vaibhav A.} and Spencer, {Stephen M.} and Harenski, {Keith A.} and Beatriz Luna and Sweeney, {John A.}",

note = "Funding Information: We thank Melissa Ziegler, MS for help with clinical assessments. This study was supported by NIMH grants MH45203 and MH01180 and a NARSAD Established Investigator Award (M.S.K.).",

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AU - Spencer, Stephen M.

AU - Harenski, Keith A.

AU - Luna, Beatriz

AU - Sweeney, John A.

N1 - Funding Information: We thank Melissa Ziegler, MS for help with clinical assessments. This study was supported by NIMH grants MH45203 and MH01180 and a NARSAD Established Investigator Award (M.S.K.).

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A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents

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