A proposed model of fat packaging by exchangeable lipid droplet proteins

Nathan E. Wolins, Dawn L. Brasaemle, Perry E. Bickel

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

Humans have evolved mechanisms of efficient fat storage to survive famine, but these mechanisms contribute to obesity in our current environment of plentiful food and reduced activity. Little is known about how animals package fat within cells. Five related structural proteins serve roles in packaging fat into lipid droplets. The proteins TIP47, S3-12, and OXPAT/MLDP/PAT-1 move from the cytosol to coat nascent lipid droplets during rapid fat storage. In contrast, perilipin and adipophilin constitutively associate with lipid droplets and play roles in sustained fat storage and regulation of lipolysis. Different tissues express different complements of these lipid droplet proteins. Thus, the tissue-specific complement of these proteins determines how tissues manage lipid stores.

Original languageEnglish (US)
Pages (from-to)5484-5491
Number of pages8
JournalFEBS Letters
Volume580
Issue number23
DOIs
StatePublished - Oct 9 2006

Fingerprint

Product Packaging
Packaging
Fats
Lipids
Tissue
Proteins
Lipolysis
Starvation
Adipocytes
Cytosol
Complement System Proteins
Obesity
Animals
Food
Lipid Droplet Associated Proteins
Lipid Droplets

Keywords

  • Adipophilin
  • ADRP
  • Lipid droplet
  • MLDP
  • OXPAT
  • PAT proteins
  • PAT-1
  • Perilipin
  • S3-12
  • TIP47
  • Triacylglycerol

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

A proposed model of fat packaging by exchangeable lipid droplet proteins. / Wolins, Nathan E.; Brasaemle, Dawn L.; Bickel, Perry E.

In: FEBS Letters, Vol. 580, No. 23, 09.10.2006, p. 5484-5491.

Research output: Contribution to journalArticle

Wolins, Nathan E. ; Brasaemle, Dawn L. ; Bickel, Perry E. / A proposed model of fat packaging by exchangeable lipid droplet proteins. In: FEBS Letters. 2006 ; Vol. 580, No. 23. pp. 5484-5491.
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