Original language | English (US) |
---|---|
Pages (from-to) | 341-343 |
Number of pages | 3 |
Journal | BBA - Biochimica et Biophysica Acta |
Volume | 70 |
Issue number | C |
DOIs | |
State | Published - 1963 |
ASJC Scopus subject areas
- Medicine(all)
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A reciprocal relationship between fatty acid and cholesterol biosynthesis. / Foster, Daniel W.; Bloom, Ben.
In: BBA - Biochimica et Biophysica Acta, Vol. 70, No. C, 1963, p. 341-343.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - A reciprocal relationship between fatty acid and cholesterol biosynthesis
AU - Foster, Daniel W.
AU - Bloom, Ben
N1 - Funding Information: microsomal-supernatfaranct tionw asi ncubatedw ith avidin. It was anticipatetdh at inhibitiono f fattya cids ynthesiws ouldr esulti n astimulatioonf cholesterosyl nthesis. As can be seen,h oweverb, othc holesteroaln d fatty acid synthesiws ereinhibited. The inhibitiono f cholesterosly nthesihsa sb eenr egularlyo bservedt,h ought o varying degreesw, ith differentb atcheso f commerciallpyr epareda vidin (NutritionaBl io-chemicalCs orp.,C levelandO, hio, (U.S.A.)). Whetherth ee ffectr epresentins hibition of CO s fixationo r whetherit is non-specificd,u e perhapst o a contaminanint the avidin, is not known at present.I t should be noted that FLETCHER AND MYANT~ observedn o inhibitiono f cholesterosly nthesisb y avidin in their studies. The fact that the citratee ffecto n fatty acid biosynthesiwsa s demonstrateind tissues licesi n thesee xperimentwsh ereasM ASOROe t al. 5 found no such effectm ay be relatedto the muchl owerc oncentratioonf citrateu sedb y the latteri nvestigators. The existencoef a citratee ffectin the intactc ellas well as in homogenataens dpurified enzymes ystemsd oes not, of course,i mply physiologicasli gnificanceW. hile the concentratioonf citrateu sedhere is comparablteo that used in previousin vesti-gationss-l° it is considerablgyr eatetrh anl evelsn ormallyp resenitn rat liver, where, per gramo f tissueo btainedfr omfed rats,v alueso f 0.25-0.50/zmocleit rateh aveb een observe1d~ . This study was supportedin part by Grant AM-o6358-oif rom the National Instituteso f Health,U .S. Public HealthS ervice. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1963
Y1 - 1963
UR - http://www.scopus.com/inward/record.url?scp=50549188847&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50549188847&partnerID=8YFLogxK
U2 - 10.1016/0006-3002(63)90759-5
DO - 10.1016/0006-3002(63)90759-5
M3 - Article
C2 - 13958892
AN - SCOPUS:50549188847
VL - 70
SP - 341
EP - 343
JO - BBA - Biochimica et Biophysica Acta
JF - BBA - Biochimica et Biophysica Acta
SN - 0006-3002
IS - C
ER -