A reciprocal relationship between fatty acid and cholesterol biosynthesis

Daniel W. Foster; Ben Bloom

doi:10.1016/0006-3002(63)90759-5

A reciprocal relationship between fatty acid and cholesterol biosynthesis

Research output: Contribution to journal › Article › peer-review

Original language	English (US)
Pages (from-to)	341-343
Number of pages	3
Journal	BBA - Biochimica et Biophysica Acta
Volume	70
Issue number	C
DOIs	https://doi.org/10.1016/0006-3002(63)90759-5
State	Published - 1963

ASJC Scopus subject areas

Medicine(all)

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10.1016/0006-3002(63)90759-5

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@article{26cab21406ee45f38de8d6e70e5c5923,

title = "A reciprocal relationship between fatty acid and cholesterol biosynthesis",

author = "Foster, {Daniel W.} and Ben Bloom",

note = "Funding Information: microsomal-supernatfaranct tionw asi ncubatedw ith avidin. It was anticipatetdh at inhibitiono f fattya cids ynthesiws ouldr esulti n astimulatioonf cholesterosyl nthesis. As can be seen,h oweverb, othc holesteroaln d fatty acid synthesiws ereinhibited. The inhibitiono f cholesterosly nthesihsa sb eenr egularlyo bservedt,h ought o varying degreesw, ith differentb atcheso f commerciallpyr epareda vidin (NutritionaBl io-chemicalCs orp.,C levelandO, hio, (U.S.A.)). Whetherth ee ffectr epresentins hibition of CO s fixationo r whetherit is non-specificd,u e perhapst o a contaminanint the avidin, is not known at present.I t should be noted that FLETCHER AND MYANT~ observedn o inhibitiono f cholesterosly nthesisb y avidin in their studies. The fact that the citratee ffecto n fatty acid biosynthesiwsa s demonstrateind tissues licesi n thesee xperimentwsh ereasM ASOROe t al. 5 found no such effectm ay be relatedto the muchl owerc oncentratioonf citrateu sedb y the latteri nvestigators. The existencoef a citratee ffectin the intactc ellas well as in homogenataens dpurified enzymes ystemsd oes not, of course,i mply physiologicasli gnificanceW. hile the concentratioonf citrateu sedhere is comparablteo that used in previousin vesti-gationss-l° it is considerablgyr eatetrh anl evelsn ormallyp resenitn rat liver, where, per gramo f tissueo btainedfr omfed rats,v alueso f 0.25-0.50/zmocleit rateh aveb een observe1d~ . This study was supportedin part by Grant AM-o6358-oif rom the National Instituteso f Health,U .S. Public HealthS ervice. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1963",

doi = "10.1016/0006-3002(63)90759-5",

language = "English (US)",

volume = "70",

pages = "341--343",

journal = "BBA - Biochimica et Biophysica Acta",

issn = "0006-3002",

number = "C",

}

TY - JOUR

T1 - A reciprocal relationship between fatty acid and cholesterol biosynthesis

AU - Foster, Daniel W.

AU - Bloom, Ben

N1 - Funding Information: microsomal-supernatfaranct tionw asi ncubatedw ith avidin. It was anticipatetdh at inhibitiono f fattya cids ynthesiws ouldr esulti n astimulatioonf cholesterosyl nthesis. As can be seen,h oweverb, othc holesteroaln d fatty acid synthesiws ereinhibited. The inhibitiono f cholesterosly nthesihsa sb eenr egularlyo bservedt,h ought o varying degreesw, ith differentb atcheso f commerciallpyr epareda vidin (NutritionaBl io-chemicalCs orp.,C levelandO, hio, (U.S.A.)). Whetherth ee ffectr epresentins hibition of CO s fixationo r whetherit is non-specificd,u e perhapst o a contaminanint the avidin, is not known at present.I t should be noted that FLETCHER AND MYANT~ observedn o inhibitiono f cholesterosly nthesisb y avidin in their studies. The fact that the citratee ffecto n fatty acid biosynthesiwsa s demonstrateind tissues licesi n thesee xperimentwsh ereasM ASOROe t al. 5 found no such effectm ay be relatedto the muchl owerc oncentratioonf citrateu sedb y the latteri nvestigators. The existencoef a citratee ffectin the intactc ellas well as in homogenataens dpurified enzymes ystemsd oes not, of course,i mply physiologicasli gnificanceW. hile the concentratioonf citrateu sedhere is comparablteo that used in previousin vesti-gationss-l° it is considerablgyr eatetrh anl evelsn ormallyp resenitn rat liver, where, per gramo f tissueo btainedfr omfed rats,v alueso f 0.25-0.50/zmocleit rateh aveb een observe1d~ . This study was supportedin part by Grant AM-o6358-oif rom the National Instituteso f Health,U .S. Public HealthS ervice. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1963

Y1 - 1963

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U2 - 10.1016/0006-3002(63)90759-5

DO - 10.1016/0006-3002(63)90759-5

M3 - Article

C2 - 13958892

AN - SCOPUS:50549188847

VL - 70

SP - 341

EP - 343

JO - BBA - Biochimica et Biophysica Acta

JF - BBA - Biochimica et Biophysica Acta

SN - 0006-3002

IS - C

ER -

A reciprocal relationship between fatty acid and cholesterol biosynthesis

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