A responsive europium(III) chelate that provides a direct readout of pH by MRI

Yunkou Wu; Todd C. Soesbe; Garry E. Kiefer; Piyu Zhao; A. Dean Sherry

doi:10.1021/ja106018n

A responsive europium(III) chelate that provides a direct readout of pH by MRI

Yunkou Wu, Todd C. Soesbe, Garry E. Kiefer, Piyu Zhao, A. Dean Sherry

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

A europium(III) DO3A-tris(amide) complex is reported for imaging pH by MRI using ratiometric chemical exchange saturation transfer (CEST) principles. Deprotonation of a single phenolic proton between pH 6 and 7.6 results in an ∼5 ppm shift in the water exchange CEST peak that is easily detected by MRI. Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker.

Original language	English (US)
Pages (from-to)	14002-14003
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	132
Issue number	40
DOIs	https://doi.org/10.1021/ja106018n
State	Published - Oct 13 2010

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja106018n

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abstract = "A europium(III) DO3A-tris(amide) complex is reported for imaging pH by MRI using ratiometric chemical exchange saturation transfer (CEST) principles. Deprotonation of a single phenolic proton between pH 6 and 7.6 results in an ∼5 ppm shift in the water exchange CEST peak that is easily detected by MRI. Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker.",

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AU - Wu, Yunkou

AU - Soesbe, Todd C.

AU - Kiefer, Garry E.

AU - Zhao, Piyu

AU - Sherry, A. Dean

PY - 2010/10/13

Y1 - 2010/10/13

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AB - A europium(III) DO3A-tris(amide) complex is reported for imaging pH by MRI using ratiometric chemical exchange saturation transfer (CEST) principles. Deprotonation of a single phenolic proton between pH 6 and 7.6 results in an ∼5 ppm shift in the water exchange CEST peak that is easily detected by MRI. Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker.

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A responsive europium(III) chelate that provides a direct readout of pH by MRI

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