A responsive europium(III) chelate that provides a direct readout of pH by MRI

Yunkou Wu, Todd C. Soesbe, Garry E. Kiefer, Piyu Zhao, A. Dean Sherry

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

A europium(III) DO3A-tris(amide) complex is reported for imaging pH by MRI using ratiometric chemical exchange saturation transfer (CEST) principles. Deprotonation of a single phenolic proton between pH 6 and 7.6 results in an ∼5 ppm shift in the water exchange CEST peak that is easily detected by MRI. Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker.

Original languageEnglish (US)
Pages (from-to)14002-14003
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number40
DOIs
StatePublished - Oct 13 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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