A responsive europium(III) chelate that provides a direct readout of pH by MRI

Yunkou Wu, Todd C. Soesbe, Garry E. Kiefer, Piyu Zhao, A. Dean Sherry

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

A europium(III) DO3A-tris(amide) complex is reported for imaging pH by MRI using ratiometric chemical exchange saturation transfer (CEST) principles. Deprotonation of a single phenolic proton between pH 6 and 7.6 results in an ∼5 ppm shift in the water exchange CEST peak that is easily detected by MRI. Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker.

Original languageEnglish (US)
Pages (from-to)14002-14003
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number40
DOIs
StatePublished - Oct 13 2010

Fingerprint

Europium
Magnetic resonance imaging
Ion exchange
Deprotonation
Amides
Protons
Chemical activation
Imaging techniques
Water
europium(III) chelate-2,2',2'',2'''-((4-((4-isothiocyanatophenyl)ethynyl)pyridine-2,6-diyl)bis(methylenenitrilo))tetrakis(acetic acid)

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

A responsive europium(III) chelate that provides a direct readout of pH by MRI. / Wu, Yunkou; Soesbe, Todd C.; Kiefer, Garry E.; Zhao, Piyu; Sherry, A. Dean.

In: Journal of the American Chemical Society, Vol. 132, No. 40, 13.10.2010, p. 14002-14003.

Research output: Contribution to journalArticle

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