A role for clathrin light chains in the recognition of clathrin cages by 'uncoating ATPase'

Sandra L. Schmid, William A. Braell, David M. Schlossman, James E. Rothman

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

A cycle of clathrin assembly and disassembly drives the formation of coated vesicles, intermediates in intracellular protein transport. The heavy chain of clathrin is needed for assembly, but the function of the clathrin light chains has remained obscure. An enzyme has now been purified which uses ATP hydrolysis to power the release of clathrin from coated vesicles, presumably recycling the coat protein for repeated rounds of vesicle budding. This 'uncoating ATPase' requires clathrin light chains for its action.

Original languageEnglish (US)
Pages (from-to)228-231
Number of pages4
JournalNature
Volume311
Issue number5983
DOIs
StatePublished - 1984

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Clathrin Light Chains
Clathrin
Adenosine Triphosphatases
Clathrin Heavy Chains
Clathrin-Coated Vesicles
Coated Vesicles
Capsid Proteins
Recycling
Protein Transport
Hydrolysis
Adenosine Triphosphate
Enzymes

ASJC Scopus subject areas

  • General

Cite this

A role for clathrin light chains in the recognition of clathrin cages by 'uncoating ATPase'. / Schmid, Sandra L.; Braell, William A.; Schlossman, David M.; Rothman, James E.

In: Nature, Vol. 311, No. 5983, 1984, p. 228-231.

Research output: Contribution to journalArticle

Schmid, Sandra L. ; Braell, William A. ; Schlossman, David M. ; Rothman, James E. / A role for clathrin light chains in the recognition of clathrin cages by 'uncoating ATPase'. In: Nature. 1984 ; Vol. 311, No. 5983. pp. 228-231.
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