A role for histone deacetylases in the cellular and behavioral mechanisms underlying learning and memory

Melissa Mahgoub, Lisa M Monteggia

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Histone deacetylases (HDACs) are a family of chromatin remodeling enzymes that restrict access of transcription factors to the DNA, thereby repressing gene expression. In contrast, histone acetyltransferases (HATs) relax the chromatin structure allowing for an active chromatin state and promoting gene transcription. Accumulating data have demonstrated a crucial function for histone acetylation and histone deacetylation in regulating the cellular and behavioral mechanisms underlying synaptic plasticity and learning and memory. In trying to delineate the roles of individual HDACs, genetic tools have been used to manipulate HDAC expression in rodents, uncovering distinct contributions of individual HDACs in regulating the processes of memory formation. Moreover, recent findings have suggested an important role for HDAC inhibitors in enhancing learning and memory processes as well as ameliorating symptoms related to neurodegenerative diseases. In this review, we focus on the role of HDACs in learning and memory, as well as significant data emerging from the field in support of HDAC inhibitors as potential therapeutic targets for the treatment of cognitive disorders.

Original languageEnglish (US)
Pages (from-to)564-568
Number of pages5
JournalLearning and Memory
Volume21
Issue number10
DOIs
StatePublished - Oct 1 2014

Fingerprint

Histone Deacetylases
Learning
Histones
Chromatin
Histone Acetyltransferases
Neuronal Plasticity
Chromatin Assembly and Disassembly
Acetylation
Neurodegenerative Diseases
Rodentia
Transcription Factors
Gene Expression
DNA
Enzymes
Genes

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

A role for histone deacetylases in the cellular and behavioral mechanisms underlying learning and memory. / Mahgoub, Melissa; Monteggia, Lisa M.

In: Learning and Memory, Vol. 21, No. 10, 01.10.2014, p. 564-568.

Research output: Contribution to journalArticle

Mahgoub, Melissa ; Monteggia, Lisa M. / A role for histone deacetylases in the cellular and behavioral mechanisms underlying learning and memory. In: Learning and Memory. 2014 ; Vol. 21, No. 10. pp. 564-568.
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