A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila

Evgueni A. Sevrioukov, Jing Ping He, Nabil Moghrabi, Arisa Sunio, Helmut Krämer

Research output: Contribution to journalArticlepeer-review

175 Scopus citations

Abstract

Deep orange and carnation are two of the classic eye color genes in Drosophila. Here, we demonstrate that Deep orange is part of a protein complex that localizes to endosomal compartments. A second component of this complex is Carnation, a homolog of Sec1p-like regulators of membrane fusion. Because complete loss of deep orange function is lethal, the role of this complex in intracellular trafficking was analyzed in deep orange mutant clones. Retinal cells devoid of deep orange function completely lacked pigmentation and exhibited exaggerated multivesicular structures. Furthermore, a defect in endocytic trafficking was visualized in developing photoreceptor cells. These results provide direct evidence that eye color mutations of the granule group also disrupt vesicular trafficking to lysosomes.

Original languageEnglish (US)
Pages (from-to)479-486
Number of pages8
JournalMolecular cell
Volume4
Issue number4
DOIs
StatePublished - Oct 1999

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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