TY - JOUR
T1 - A systematic review of the incidence and prevalence of cardiac, cerebrovascular, and peripheral vascular disease in multiple sclerosis
AU - Marrie, Ruth Ann
AU - Reider, Nadia
AU - Cohen, Jeffrey
AU - Stuve, Olaf
AU - Trojano, Maria
AU - Cutter, Gary
AU - Reingold, Stephen
AU - Sorensen, Per Soelberg
N1 - Funding Information:
This work was supported (in part) by the National Multiple Sclerosis Society and a Don Paty Career Development Award from the MS Society of Canada.
Funding Information:
Ruth Ann Marrie receives research funding from: Canadian Institutes of Health Research, Public Health Agency of Canada, Manitoba Health Research Council, Health Sciences Centre Foundation, Multiple Sclerosis Society of Canada, Multiple Sclerosis Scientific Foundation, Rx & D Health Research Foundation, and has conducted clinical trials funded by Sanofi-Aventis.
Funding Information:
Olaf Stuve is an associate editor of JAMA Neurology, and he serves on the editorial boards of the Multiple Sclerosis Journal, Clinical and Experimental Immunology, and Therapeutic Advances in Neurological Disorders. He has participated in data and safety monitoring committees for Pfizer and Sanofi. Dr Stuve has received grant support from Teva Pharmaceuticals.
PY - 2015/3/16
Y1 - 2015/3/16
N2 - Background: Findings regarding the prevalence of vascular comorbidities in multiple sclerosis (MS) are conflicting.Objective: The objective of this review is to estimate the incidence and prevalence of vascular comorbidities and predisposing comorbidities in persons with MS and to assess the quality of the included studies.Methods: The PubMed, EMBASE, SCOPUS and Web of Knowledge databases, conference proceedings, and reference lists of retrieved articles were searched. One reviewer abstracted data using a standardized data collection form, while the second reviewer verified the abstraction. Included studies were assessed qualitatively. Quantitatively, we assessed studies using the I 2 statistic, and conducted meta-analyses for population-based studies only.Results: The prevalence of hypertension and hyperlipidemia exceeded 10% in the MS population and increased with age. While the prevalence of ischemic heart disease, congestive heart failure, and stroke were less than 5% overall, the prevalence of these conditions exceeded expectations when compared to the general population. Cardiac valvular disease, however, affected the MS population less often than expected. Problems with study quality were common.Conclusion: Despite the relatively high prevalence of some vascular comorbidities in the MS population, important gaps exist in our understanding of their epidemiology. Most of our knowledge is based on studies conducted in a small number of regions.
AB - Background: Findings regarding the prevalence of vascular comorbidities in multiple sclerosis (MS) are conflicting.Objective: The objective of this review is to estimate the incidence and prevalence of vascular comorbidities and predisposing comorbidities in persons with MS and to assess the quality of the included studies.Methods: The PubMed, EMBASE, SCOPUS and Web of Knowledge databases, conference proceedings, and reference lists of retrieved articles were searched. One reviewer abstracted data using a standardized data collection form, while the second reviewer verified the abstraction. Included studies were assessed qualitatively. Quantitatively, we assessed studies using the I 2 statistic, and conducted meta-analyses for population-based studies only.Results: The prevalence of hypertension and hyperlipidemia exceeded 10% in the MS population and increased with age. While the prevalence of ischemic heart disease, congestive heart failure, and stroke were less than 5% overall, the prevalence of these conditions exceeded expectations when compared to the general population. Cardiac valvular disease, however, affected the MS population less often than expected. Problems with study quality were common.Conclusion: Despite the relatively high prevalence of some vascular comorbidities in the MS population, important gaps exist in our understanding of their epidemiology. Most of our knowledge is based on studies conducted in a small number of regions.
KW - Multiple sclerosis
KW - cardiac
KW - comorbidity
KW - incidence
KW - peripheral vascular disease
KW - prevalence
KW - stroke
KW - systematic review
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U2 - 10.1177/1352458514564485
DO - 10.1177/1352458514564485
M3 - Review article
C2 - 25533300
AN - SCOPUS:84924762891
SN - 1352-4585
VL - 21
SP - 318
EP - 331
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 3
ER -