A systematic review of the incidence and prevalence of cardiac, cerebrovascular, and peripheral vascular disease in multiple sclerosis

Ruth Ann Marrie, Nadia Reider, Jeffrey Cohen, Olaf Stuve, Maria Trojano, Gary Cutter, Stephen Reingold, Per Soelberg Sorensen

Research output: Contribution to journalReview article

65 Scopus citations

Abstract

Background: Findings regarding the prevalence of vascular comorbidities in multiple sclerosis (MS) are conflicting.Objective: The objective of this review is to estimate the incidence and prevalence of vascular comorbidities and predisposing comorbidities in persons with MS and to assess the quality of the included studies.Methods: The PubMed, EMBASE, SCOPUS and Web of Knowledge databases, conference proceedings, and reference lists of retrieved articles were searched. One reviewer abstracted data using a standardized data collection form, while the second reviewer verified the abstraction. Included studies were assessed qualitatively. Quantitatively, we assessed studies using the I 2 statistic, and conducted meta-analyses for population-based studies only.Results: The prevalence of hypertension and hyperlipidemia exceeded 10% in the MS population and increased with age. While the prevalence of ischemic heart disease, congestive heart failure, and stroke were less than 5% overall, the prevalence of these conditions exceeded expectations when compared to the general population. Cardiac valvular disease, however, affected the MS population less often than expected. Problems with study quality were common.Conclusion: Despite the relatively high prevalence of some vascular comorbidities in the MS population, important gaps exist in our understanding of their epidemiology. Most of our knowledge is based on studies conducted in a small number of regions.

Original languageEnglish (US)
Pages (from-to)318-331
Number of pages14
JournalMultiple Sclerosis Journal
Volume21
Issue number3
DOIs
StatePublished - Mar 16 2015

Keywords

  • Multiple sclerosis
  • cardiac
  • comorbidity
  • incidence
  • peripheral vascular disease
  • prevalence
  • stroke
  • systematic review

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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