@article{155033b67a044ce8b5e9264335912d96,
title = "A Tissue Engineering Approach to Metastatic Colon Cancer",
abstract = "Colon cancer remains the third most common cause of cancer in the US, and the third most common cause of cancer death. Worldwide, colon cancer is the second most common cause of cancer and cancer deaths. At least 25% of patients still present with metastatic disease, and at least 25-30% will develop metastatic colon cancer in the course of their disease. While chemotherapy and surgery remain the mainstay of treatment, understanding the fundamental cellular niche and mechanical properties that result in metastases would facilitate both prevention and cure. Advances in biomaterials, novel 3D primary human cells, modelling using microfluidics and the ability to alter the physical environment, now offers a unique opportunity to develop and test impactful treatment.",
keywords = "Bioengineering, Cancer, Disease",
author = "Sarvestani, {Samaneh Kamali} and DeHaan, {Reece K.} and Miller, {Paula G.} and Shree Bose and Xiling Shen and Shuler, {Michael L.} and Huang, {Emina H.}",
note = "Funding Information: The authors are thankful for the careful review of the manuscript by Cassandra Talerico, PhD. M.L.S, X.S. and E.H.H. are supported by the Tissue Engineering Consortium of the NCI, U01 CA214300. E.H.H. receives additional support from R01 CA237304. X.S. receives additional support from U01 CA217514. M.L.S. receives support from NIH R44TR001326. Conceptualization, E.H.H. and M.L.S.; Writing ? Original Draft, R.K.D. S.K.S. P.G.M. and S.B.; Writing ? Review and Editing, M.L.S. and E.H.H.; Funding Acquisition, M.L.S. X.S. and E.H.H.; Supervision, M.L.S. X.S. and E.H.H. M.L.S. is CEO/President of Hesperos, Inc and has several patents related to ?body-on-a-chip? technology: US Pat 7,288,045; 8748180 B2; 9,273,276 B2 and one application pending. X.S. is the co-founder and CEO of Xilis, Inc. The topics covered in this paper have no overlap with Xilis' operation or financial interest. Funding Information: The authors are thankful for the careful review of the manuscript by Cassandra Talerico, PhD. M.L.S, X.S., and E.H.H. are supported by the Tissue Engineering Consortium of the NCI, U01 CA214300 . E.H.H. receives additional support from R01 CA237304 . X.S. receives additional support from U01 CA217514 . M.L.S. receives support from NIH R44TR001326 . Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = nov,
day = "20",
doi = "10.1016/j.isci.2020.101719",
language = "English (US)",
volume = "23",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "11",
}