A Transforming Growth Factor β Receptor Type II Gene Mutation Common in Colon and Gastric but Rare in Endometrial Cancers with Microsatellite Instability

L. L. Myeroff, R. Parsons, S. J. Kim, L. Hedrick, K. R. Cho, K. Orth, M. Mathis, K. W. Kinzler, J. Lutterbaugh, K. Park, Y. J. Bang, Young Lee Hwa Young Lee, J. G. Park -, H. T. Lynch, A. B. Roberts, B. Vogelstein, S. D. Markowitz

Research output: Contribution to journalArticlepeer-review

447 Scopus citations

Abstract

We have recently demonstrated that mutation of the transforming growth factor-β (TGF-β) receptor type II (RH) gene is characteristic of colon cancers exhibiting microsatellite instability or replication errors (RER+). Moreover, we have shown that RH mutations in these RER+ colon cancers are characteristically frameshift mutations within a 10-bp polyadenine repeat present in the RII-coding region. We now show that RH gene mutations in this polyadenine repeat are also commonly present in RER+ gastric cancers (71%). In contrast, we find these same RH gene mutations are distinctly uncommon in RER+ endometrial cancers (17%, P < 0.02). These results suggest that RH gene mutations confer a growth advantage and are selected for in RER+ cancers of both the upper and lower gastrointestinal tract. The genesis of RER+ endometrial tumors must, however, be by a different route.

Original languageEnglish (US)
Pages (from-to)5545-5547
Number of pages3
JournalCancer research
Volume55
Issue number23
StatePublished - Dec 1 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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