Abate and Switch: miR-145 in Stem Cell Differentiation

Raghu R. Chivukula, Joshua T. Mendell

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.

Original languageEnglish (US)
Pages (from-to)606-608
Number of pages3
JournalCell
Volume137
Issue number4
DOIs
StatePublished - May 15 2009

Fingerprint

Temefos
Embryonic Stem Cells
Stem cells
Cell Differentiation
Stem Cells
Switches
MicroRNAs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Abate and Switch : miR-145 in Stem Cell Differentiation. / Chivukula, Raghu R.; Mendell, Joshua T.

In: Cell, Vol. 137, No. 4, 15.05.2009, p. 606-608.

Research output: Contribution to journalArticle

Chivukula, Raghu R. ; Mendell, Joshua T. / Abate and Switch : miR-145 in Stem Cell Differentiation. In: Cell. 2009 ; Vol. 137, No. 4. pp. 606-608.
@article{8df7899b5e634bbe9922f4ea732ca809,
title = "Abate and Switch: miR-145 in Stem Cell Differentiation",
abstract = "MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.",
author = "Chivukula, {Raghu R.} and Mendell, {Joshua T.}",
year = "2009",
month = "5",
day = "15",
doi = "10.1016/j.cell.2009.04.059",
language = "English (US)",
volume = "137",
pages = "606--608",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - Abate and Switch

T2 - miR-145 in Stem Cell Differentiation

AU - Chivukula, Raghu R.

AU - Mendell, Joshua T.

PY - 2009/5/15

Y1 - 2009/5/15

N2 - MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.

AB - MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.

UR - http://www.scopus.com/inward/record.url?scp=65549114101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65549114101&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2009.04.059

DO - 10.1016/j.cell.2009.04.059

M3 - Article

C2 - 19450510

AN - SCOPUS:65549114101

VL - 137

SP - 606

EP - 608

JO - Cell

JF - Cell

SN - 0092-8674

IS - 4

ER -