Abate and Switch: miR-145 in Stem Cell Differentiation

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Abstract

MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.

Original languageEnglish (US)
Pages (from-to)606-608
Number of pages3
JournalCell
Volume137
Issue number4
DOIs
Publication statusPublished - May 15 2009

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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